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  • 5-O-对香豆酰基奎宁酸

    5-O-Coumaroylquinic acid

    5-O-对香豆酰基奎宁酸
    产品编号 CFN95507
    CAS编号 32451-86-8
    分子式 = 分子量 C16H18O8 = 338.3
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Phenylpropanoids
    植物来源 The herbs of Solanum lycopersicum
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    5-O-对香豆酰基奎宁酸 CFN95507 32451-86-8 1mg QQ客服:1457312923
    5-O-对香豆酰基奎宁酸 CFN95507 32451-86-8 5mg QQ客服:1457312923
    5-O-对香豆酰基奎宁酸 CFN95507 32451-86-8 10mg QQ客服:1457312923
    5-O-对香豆酰基奎宁酸 CFN95507 32451-86-8 20mg QQ客服:1457312923
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Nutrients.2018, 10(7)
  • International. J. of Food Properties 2017, 20:S131-S140
  • Molecules.2019, 24(2):329
  • Food Science and Biotechnology2015, 2205-2212
  • ACS Omega2020, 5,33,20825-20830
  • Biomolecules.2020, 10(6):925.
  • Virulence.2018, 9(1):588-603
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  • Food Addit Contam Part A.2021, 38(12):1985-1994.
  • J Ethnopharmacol.2020, 260:112988.
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  • Food Chem.2019, 278:683-691
  • J of l. Chroma.&Related Tech2020, 43(11-12):414-423.
  • Acta Pharm Sin B.2015, 5(4):323-9.
  • Molecules.2020 ,25(16):3697.
  • Korean Journal of Pharmacognosy2018, 49(4):349-361
  • Foods2023, 12(23), 4342.
  • BMC Complement Altern Med.2017, 17(1):393
  • Anal Bioanal Chem.2020, 412(12):3005-3015.
  • Environ Toxicol.2019, 34(12):1354-1362
  • J Exp Bot.2016, 67(12):3777-88
  • Front Chem.2022, 10:1048467.
  • Int J Mol Sci.2019, 21(1):E265
  • ...
  • 生物活性
    Description: 5-O-Coumaroylquinic acid has a considerable inhibitory effect on PTP1B.5-O-Coumaroylquinic acid( 3-O-Coumaroylquinic acid) shows a significant concentration-dependent inhibitory effect on α-glucosidase, so it has anti-hyperglycemic effect.5-O-Coumaroylquinic acid(3-O-Coumaroylquinine acid) enhances glucose uptake and inhibits PTP1B in vitro.
    In vitro:
    J Ethnopharmacol . 2014 Mar 28;152(3):599-602.
    Walnut leaf extract inhibits PTP1B and enhances glucose-uptake in vitro[Pubmed: 24548753]
    Ethnopharmacological relevance: Walnut, Juglans regia L. (Juglandaceae), is one of the medicinal plants used to treat diabetic symptoms in Austrian folk medicine. The air-dried green leaves are either used as aqueous decoctions or liquor preparations and are consumed on a daily basis. We investigated the hypoglycemic effect of a methanolic Juglans regia leaf extract on glucose uptake, protein tyrosine phosphatase 1B (PTP1B) inhibition and peroxisome proliferator-activated receptor gamma (PPARγ) activation. Material and methods: Hypoglycemic activity was assessed by glucose-uptake in C2C12 myocytes, inhibition of PTP1B and activation of PPARγ. Phytochemical characterization of the extract was carried out by LC-MS and GC-MS. Results: Methanolic Juglans regia leaf extract enhanced the glucose uptake rate in C2C12 myocytes at concentrations of 25μg/mL compared to untreated cells. This activity may partly be explained by the inhibition of PTP1B but not PPARγ agonism. LC-MS analyses revealed chlorogenic acid (1), 3-p-coumaroylquinic acid (2), a trihydroxynaphthalene-hexoside (3), as well as eight flavonoids (4-11) as main phenolic constituents in the active extract. Conclusions: The finding that Juglans regia leaf extract enhances glucose uptake and inhibits PTP1B provides an in vitro-based rationale for the traditional use of walnut leaf preparations against elevated blood-glucose levels.
    In vivo:
    Fitoterapia . 2014 Dec;99:1-6.
    Caffeoylquinic acid derivatives isolated from the aerial parts of Gynura divaricata and their yeast α-glucosidase and PTP1B inhibitory activity[Pubmed: 25172103]
    The phytochemical investigation of natural products of Gynura divaricata led to the isolation of eleven caffeoylquinic acid derivatives. They were characterized by spectrometric methods as 5-O-caffeoylquinic acid (1), 5-O-p-coumaroylquinic acid (2), 5-O-feruloylquinic acid (3), methyl 5-O-caffeoylquinate (4), 3,4-dicaffeoylquinic acid (5), 3,5-dicaffeoylquinic acid (6), 4,5-dicaffeoylquinic acid (7), methyl 3,4-dicaffeoylquinate (8), methyl 3,5-dicaffeoylquinate (9), methyl 4,5-dicaffeoylquinate (10) and ethyl 4,5-dicaffeoylquinate (11). The individual compounds were screened for the inhibition of yeast α-glucosidase and Protein Tyrosine Phosphatase 1B (PTP1B) using in vitro assays. Among the isolated compounds, 3,4-dicaffeoylquinic acid (5), 4,5-dicaffeoylquinic acid (7), methyl 3,4-dicaffeoylquinate (8) and methyl 4,5-dicaffeoylquinate (10) exhibited significant inhibitory activities against α-glucosidase. In addition, 5-O-p-coumaroylquinic acid (2), 3,5-dicaffeoylquinic acid (6) and 4,5-dicaffeoylquinic acid (7) had considerable inhibitory effect against PTP1B. Based on these findings, the caffeoylquinic acid derivatives were deduced to be potentially responsible for the anti-diabetic activity of G. divaricata. The preliminary structure-activity relationship study suggests that the number and positioning of caffeoyl groups in the quinic acid derivatives are important for both α-glucosidase and PTP1B inhibitory potency. Moreover, the corresponding methyl esters of some dicaffeoylquinic acids have enhanced inhibitory activity against yeast α-glucosidase.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.956 mL 14.7798 mL 29.5596 mL 59.1191 mL 73.8989 mL
    5 mM 0.5912 mL 2.956 mL 5.9119 mL 11.8238 mL 14.7798 mL
    10 mM 0.2956 mL 1.478 mL 2.956 mL 5.9119 mL 7.3899 mL
    50 mM 0.0591 mL 0.2956 mL 0.5912 mL 1.1824 mL 1.478 mL
    100 mM 0.0296 mL 0.1478 mL 0.2956 mL 0.5912 mL 0.739 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    隐绿原酸; Cryptochlorogenic acid CFN99117 905-99-7 C16H18O9 = 354.31 20mg QQ客服:3257982914
    甲基 4-咖啡酰奎尼酸酯; Methyl 4-caffeoylquinate CFN92528 123372-74-7 C17H20O9 = 368.3 5mg QQ客服:2056216494
    4-O-阿魏酰奎尼酸; 4-O-Feruloylquinic acid CFN92392 2613-86-7 C17H20O9 = 368.3 10mg QQ客服:1457312923
    5-O-对香豆酰基奎宁酸; 5-O-Coumaroylquinic acid CFN95507 32451-86-8 C16H18O8 = 338.3 5mg QQ客服:1413575084
    新绿原酸; Neochlorogenic acid CFN97472 906-33-2 C16H18O9 = 354.3 20mg QQ客服:1457312923
    新绿原酸甲酯; Neochlorogenic acid methyl ester CFN95190 123410-65-1 C17H20O9 = 368.3 5mg QQ客服:3257982914
    5-O-阿魏酰奎尼酸; 5-O-Feruloylquinic acid CFN92889 40242-06-6 C17H20O9 = 368.3 10mg QQ客服:2056216494
    顺式5-O-阿魏酰奎尼酸; cis-5-O-Feruloylquinic acid CFN95659 87099-75-0 C17H20O9 = 368.3 10mg QQ客服:215959384
    甲基 5-O-阿魏酰奎尼酸酯; Methyl 5-O-feruloylquinate CFN92445 154461-64-0 C18H22O9 = 382.4 5mg QQ客服:215959384
    绿原酸; Chlorogenic acid CFN99116 327-97-9 C16H18O9 = 354.31 20mg QQ客服:2056216494

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