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  • 新绿原酸

    Neochlorogenic acid

    新绿原酸
    产品编号 CFN97472
    CAS编号 906-33-2
    分子式 = 分子量 C16H18O9 = 354.3
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Phenylpropanoids
    植物来源 The flowers of Lonicera japonica.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    新绿原酸 CFN97472 906-33-2 10mg QQ客服:215959384
    新绿原酸 CFN97472 906-33-2 20mg QQ客服:215959384
    新绿原酸 CFN97472 906-33-2 50mg QQ客服:215959384
    新绿原酸 CFN97472 906-33-2 100mg QQ客服:215959384
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • St. Jude Children Research Hospital (USA)
  • Korea Institute of Oriental Medicine (Korea)
  • Universita' Degli Studi Di Cagliari (Italy)
  • Institute of Tropical Disease Universitas Airlangga (Indonesia)
  • Universiti Putra Malaysia(UPM) (Malaysia)
  • Melbourne University (Australia)
  • Florida A&M University (USA)
  • Medical University of South Carolina (USA)
  • Amity University (India)
  • Macau University of Science and Technology (China)
  • Medical University of Gdansk (Poland)
  • Mendel University in Brno (Czech Republic)
  • Research Unit Molecular Epigenetics (MEG) (Germany)
  • Shanghai Institute of Biochemistry and Cell Biology (China)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Int J Mol Sci.2021, 22(12):6466.
  • Evid Based Complement Alternat Med.2021, 2021:8850744.
  • Am J Chin Med.2015, 30:1-22
  • Biomed Chromatogr.2016, 30(10):1573-81
  • Nat Prod Sci.2018, 24(2):109-114
  • Antioxidants (Basel).2021, 10(11):1831.
  • Fitoterapia.2022, 157:105130.
  • AMB Express2020. 10(1):126.
  • Org Biomol Chem.2017, 15(31):6483-6492
  • Inflammation.2020, 43(5):1716-1728.
  • Front Pharmacol.2021, 12:607403.
  • Comp. & Mathematical Methods in Med.2022, 5475559.
  • Phys Chem Chem Phys.2018, 20(23):15986-15994
  • Antioxidants (Basel).2021, 10(10):1620.
  • Saudi Pharm J.2019, 27(1):145-153
  • BMC Plant Biol.2020, 20(1):214.
  • Molecules.2019, 24(4):E744
  • Comput Biol Chem.2019, 83:107096
  • SCOPUS.2020, 836-847.
  • Anal Bioanal Chem. 2016, 408(15)
  • Plant Foods Hum Nutr.2021, 76(4):472-477.
  • Mol Pharmacol.2021, 99(2):163-174.
  • Comparative Clinical Pathology 2021, 30:961-971.
  • ...
  • 生物活性
    Description: Neochlorogenic acid shows antioxidant, antibacterial, antiviral, and antipyretic activities and exerts neuroprotective effects through the inhibition of pro-inflammatory pathways in activated microglia.
    Targets: p65 | NF-kB | NOS | COX | p38MAPK | TNF-α
    In vitro:
    J Agric Food Chem. 2011 Apr 13;59(7):3205-13.
    High chlorogenic and neochlorogenic acid levels in immature peaches reduce Monilinia laxa infection by interfering with fungal melanin biosynthesis.[Pubmed: 21370882]
    Chlorogenic acid (CGA) and its isomer, neochlorogenic acid (NCGA), were found to be the major phenolic compounds in the flesh and peel of three peach cultivars.
    METHODS AND RESULTS:
    Their concentrations are especially high in immature fruits (CGA, 151-548 mg/kg; NCGA, 85-380 mg/kg), whose resistance to the brown rot fungus, Monilinia laxa , is very high. The concentrations of these two phenolic compounds decline in maturing fruits (CGA, 77-181 mg/kg; NCGA, 30-82 mg/kg), and this decline is associated with a concomitant increase in susceptibility to brown rot infection. Other phenolic compounds found in the same HPLC chromatograms at 340 nm from each peach extract at varying sampling dates in each of the three peach cultivars were not correlated with the incidence of brown rot and appeared only in some cultivars. The incidence of brown rot for each cultivar at each sampling date was significantly negatively correlated with the NCGA (r > -0.85) and CGA (r > -0.90) contents. At concentrations that are similar to those in peach fruit, CGA does not inhibit spore germination or mycelial growth of M. laxa in culture but markedly inhibits the production of melanin-like pigments in the mycelia of M. laxa in culture (42% melanin reduction).
    CONCLUSIONS:
    Accordingly, we propose that the high concentrations of CGA and NGA in immature fruits might contribute to their reduced susceptibility or increased resistance to brown rot infection by interfering with fungal melanin production.
    Neurochem Res. 2015 Sep;40(9):1792-8.
    Neochlorogenic Acid Inhibits Lipopolysaccharide-Induced Activation and Pro-inflammatory Responses in BV2 Microglial Cells.[Pubmed: 26152332 ]
    Microglia is the resident innate immune cells that sense pathogens and tissue injury in the central nervous system. Microglia becomes activated in response to injury, infection, and other stimuli that threaten neuronal survival. Microglia activation plays an important role in neurodegenerative diseases. Neochlorogenic acid (NCA) is a natural polyphenolic compound found in dried fruits and other plants. Although previous studies have shown that phenolic acids including NCA have outstanding antioxidant, antibacterial, antiviral, and antipyretic activities, there has not yet been investigated for anti-inflammatory effects.
    METHODS AND RESULTS:
    Therefore, for the first time we have examined the potential of NCA to inhibit microglial activation and pro-inflammatory responses in the brain. We found that lipopolysaccharide-induced inducible nitric oxide synthase, and cyclooxygenase-2 expression, and nitric oxide formation was suppressed by NCA in a dose-dependent manner in BV2 microglia. NCA also inhibited the production of pro-inflammatory mediators, tumor necrosis factor-α and interleukin-1 beta. Furthermore, phosphorylated nuclear factor-kappa B p65 and p38 mitogen-activated protein kinase activation were blocked by NCA.
    CONCLUSIONS:
    Taken together, these results suggest that NCA exerts neuroprotective effects through the inhibition of pro-inflammatory pathways in activated microglia.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.8225 mL 14.1123 mL 28.2247 mL 56.4493 mL 70.5617 mL
    5 mM 0.5645 mL 2.8225 mL 5.6449 mL 11.2899 mL 14.1123 mL
    10 mM 0.2822 mL 1.4112 mL 2.8225 mL 5.6449 mL 7.0562 mL
    50 mM 0.0564 mL 0.2822 mL 0.5645 mL 1.129 mL 1.4112 mL
    100 mM 0.0282 mL 0.1411 mL 0.2822 mL 0.5645 mL 0.7056 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    绿原酸乙酯; Ethyl chlorogenate CFN91565 425408-42-0 C18H22O9 = 382.4 5mg QQ客服:1148253675
    3-O-阿魏酰奎尼酸; 3-O-Feruloylquinic acid CFN92393 1899-29-2 C17H20O9 = 368.3 5mg QQ客服:2932563308
    甲基 3-O-阿魏酰奎尼酸酯; Methyl 3-O-feruloylquinate CFN92446 154418-15-2 C18H22O9 = 382.4 5mg QQ客服:1148253675
    Cyclohexanecarboxylic acid; Cyclohexanecarboxylic acid CFN92529 327161-03-5 C16H18O9 = 354.3 5mg QQ客服:2932563308
    隐绿原酸; Cryptochlorogenic acid CFN99117 905-99-7 C16H18O9 = 354.31 20mg QQ客服:215959384
    甲基 4-咖啡酰奎尼酸酯; Methyl 4-caffeoylquinate CFN92528 123372-74-7 C17H20O9 = 368.3 5mg QQ客服:1413575084
    4-O-阿魏酰奎尼酸; 4-O-Feruloylquinic acid CFN92392 2613-86-7 C17H20O9 = 368.3 5mg QQ客服:2159513211
    新绿原酸; Neochlorogenic acid CFN97472 906-33-2 C16H18O9 = 354.3 20mg QQ客服:1148253675
    新绿原酸甲酯; Neochlorogenic acid methyl ester CFN95190 123410-65-1 C17H20O9 = 368.3 5mg QQ客服:2932563308
    5-O-阿魏酰奎尼酸; 5-O-Feruloylquinic acid CFN92889 40242-06-6 C17H20O9 = 368.3 5mg QQ客服:1148253675

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