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  • 3-没食子酰基奎宁酸

    3-Galloylquinic acid

    3-没食子酰基奎宁酸
    产品编号 CFN92829
    CAS编号 17365-11-6
    分子式 = 分子量 C14H16O10 = 344.3
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Phenols
    植物来源 The leaves of Camellia sinensis.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    3-没食子酰基奎宁酸 CFN92829 17365-11-6 1mg QQ客服:2056216494
    3-没食子酰基奎宁酸 CFN92829 17365-11-6 5mg QQ客服:2056216494
    3-没食子酰基奎宁酸 CFN92829 17365-11-6 10mg QQ客服:2056216494
    3-没食子酰基奎宁酸 CFN92829 17365-11-6 20mg QQ客服:2056216494
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Worcester Polytechnic Institute (USA)
  • Julius Kühn-Institut (Germany)
  • Chinese University of Hong Kong (China)
  • VIT University (India)
  • University of Toulouse (France)
  • University of Minnesota (USA)
  • University of Pretoria (South Africa)
  • Stanford University (USA)
  • Kitasato University (Japan)
  • Kyung Hee University (Korea)
  • University of Amsterdam (Netherlands)
  • Medical University of South Carolina (USA)
  • Colorado State University (USA)
  • Cancer Research Initatives Foundation(CARIF) (Malaysia)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Agriculture2022, 12(12), 2173.
  • Crystals2020, 10(3), 206.
  • J Chromatogr B Analyt Technol Biomed Life Sci.2019, 1124:323-330
  • Front Plant Sci.2021, 12:673337.
  • Int J Mol Sci.2021, 22(12):6466.
  • Exp Ther Med.2019, 18(6):4388-4396
  • Int J Mol Sci.2022, 23(23):14826.
  • Integr Cancer Ther.2018, 17(3):832-843
  • J Agric Food Chem.2019, 67(27):7748-7754
  • J Pain Res.2022, 15:3469-3478.
  • RSC Adv.2023, 13(9):6317-6326.
  • J Pharmaceut Biomed2020, 178:112894
  • Neurochem Res.2021, s11064-021-03449-0
  • Appl. Sci.2021, 11(19),9343.
  • Metabolites.2020, 10(12):497.
  • Am J Chin Med.2022, 1-20.
  • Molecules.2019, 25(1):E103
  • Cells.2023, 12(1):168.
  • Int J Med Sci.2021, 18(10):2155-2161.
  • Molecules.2023, 28(9):3685.
  • International J of Green Pharmacy2019, 13(3)
  • The Catharanthus Genome2022,35-83.
  • Anticancer Res.2020, 40(10):5529-5538.
  • ...
  • 生物活性
    Description: Theogallin(3-Galloylquinic acid ), its derivatives, its metabolite quinic acid, the derivatives thereof, its metabolites or the pharmaceutically acceptable salts of said substances can be used for producing a drug for use in the prophylaxis or treatment of neurological and psychiatric diseases of the central nervous system, especially of dementia such as Alzheimer's disease or Parkinson's disease, of depressions and concentration disorders such as attention deficit hyperactivity disorder.L-theanine- and theogallin-enriched decaffeinated green tea extract are able to change the physiological pattern of electrical hippocampus activity in a concentration dependent manner (EC50=3mg/L), they can improve cognition at concomitant mental relaxation in man. Theogallin also has scavenging radical activity.
    In vitro:
    J. Pharm. Pharmacol., 2007, 59(8):1131-6.
    Theogallin and L-theanine as active ingredients in decaffeinated green tea extract: I. electrophysiological characterization in the rat hippocampus in-vitro.[Pubmed: 17725856 ]
    The in-vitro hippocampus slice preparation was used to mimic a physiological situation where nervous tissue is exposed directly to the water soluble extract of green tea and some of its constituents. This investigation provides evidence that L-theanine- and theogallin(3-Galloylquinic acid )--enriched decaffeinated green tea extract is able to change the physiological pattern of electrical hippocampus activity in a concentration dependent manner (EC50 3 mg L(-1)).
    METHODS AND RESULTS:
    Of the seven fractions or single components tested (fraction containing all amino acids without L-theanine, fractions containing all amino acids plus L-theanine, glutamic acid, theogallin, its metabolites quinic acid and gallic acid, and L-theanine alone), glutamic acid produced the strongest changes in terms of increased population spike amplitude after single stimuli and increased long-term potentiation, commonly taken as representative for enhancement of spatial and time dependent memory. The presence of theogallin alone shifted the activity in the same direction. Similar results as with theogallin were obtained in the presence of quinic acid. No effect was seen with gallic acid. Opposite changes (decrease of population spike amplitude and attenuated long-term potentiation) were observed in the presence of L-theanine alone. No effects were detected during the addition of the amino acid mixture unless L-theanine was added, leading to a decrease of the responses as observed for the action of L-theanine alone.
    CONCLUSIONS:
    The results provide evidence for the involvement of several active principles in the action of enriched green tea extract on electrical brain activity. The overall enhancement of hippocampal pyramidal cell responses as observed for the crude extract seems to be due to the combined action of glutamic acid and theogallin (or its presumable metabolite quinic acid), whereas L-theanine seems to have an opposite effect. However, this action was not strong enough to antagonize the effects of glutamic acid and theogallin.The results are in line with the observation that the tested green tea extract improves cognition at concomitant mental relaxation in man.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.9044 mL 14.5222 mL 29.0444 mL 58.0889 mL 72.6111 mL
    5 mM 0.5809 mL 2.9044 mL 5.8089 mL 11.6178 mL 14.5222 mL
    10 mM 0.2904 mL 1.4522 mL 2.9044 mL 5.8089 mL 7.2611 mL
    50 mM 0.0581 mL 0.2904 mL 0.5809 mL 1.1618 mL 1.4522 mL
    100 mM 0.029 mL 0.1452 mL 0.2904 mL 0.5809 mL 0.7261 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    5-没食子酰基奎宁酸; 5-Galloylquinic acid CFN92078 53584-43-3 C14H16O10 = 344.3 5mg QQ客服:1457312923
    4-没食子酰基奎宁酸; 4-Galloylquinic acid CFN92830 110170-37-1 C14H16O10 = 344.3 5mg QQ客服:3257982914
    3-没食子酰基奎宁酸; 3-Galloylquinic acid CFN92829 17365-11-6 C14H16O10 = 344.3 5mg QQ客服:1457312923

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