2,3,5,4-四羟基二苯乙烯葡萄糖苷

2,3,5,4'-Tetrahydroxyl diphenylethylene-2-O-glucoside

	产品编号	CFN99995
	CAS编号	82373-94-2
	分子式 = 分子量	C₂₀H₂₂O₉ = 406.39
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Phenols
	植物来源	The roots of Polygonum multiflorum
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产品名称	产品编号	CAS编号	包装	QQ客服
2,3,5,4-四羟基二苯乙烯葡萄糖苷	CFN99995	82373-94-2	10mg	QQ客服：1457312923
2,3,5,4-四羟基二苯乙烯葡萄糖苷	CFN99995	82373-94-2	20mg	QQ客服：1457312923
2,3,5,4-四羟基二苯乙烯葡萄糖苷	CFN99995	82373-94-2	50mg	QQ客服：1457312923
2,3,5,4-四羟基二苯乙烯葡萄糖苷	CFN99995	82373-94-2	100mg	QQ客服：1457312923

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Description:

2,3,5,4'-Tetrahydroxyldiphenylethylene-2-O-glucoside(TSG) has potential to the prevention and treatment of Alzheimer's diseases, it not only prevents over-expression of α-synuclein at an early stage, but also reverses the increased expression of α-synuclein and inhibits the aggregation at the late stage of Tg mice. TSG suppresses PDGF-BB-induced PASMCs proliferation is associated with an inhibition of AKT / GSK3β signaling pathways. TGS, emodin and physcion also have the lipid regulation activity to an overall synergy.

Targets:

Akt | GSK-3 | P450 (e.g. CYP17) | HMG-CoA Reductase | LDL

In vitro:

J Ethnopharmacol. 2011 Oct 11;137(3):1291-9.

Hepatoxicity of major constituents and extractions of Radix Polygoni Multiflori and Radix Polygoni Multiflori Praeparata.[Pubmed: 21840387]

Radix Polygoni Multiflori (RPM) and Radix Polygoni Multiflori Praeparata (RPMP) were traditionally widely used as Chinese herbal medicine. However, liver adverse reactions caused by RPM or RPMP were frequently reported all around the world recent years. The aim of this study was to study the cytotoxicities of RPM, RPMP and their major constituents on human liver cell L-02 simultaneously.
METHODS AND RESULTS:
Multi-assays, including MTT assay, neutral red uptake (NRU) assay, LDH leakage percentage and liver enzyme secretion (AST, ALT and ALP) were used. Cytotoxicities of major chemical constituents of RPM, 2, 3, 5, 4'-tetrahydroxy-stilbene-2-O-β-D-glucoside (2,3,5,4'-Tetrahydroxyl diphenylethylene-2-O-glucoside，TSG), physcion and emodin, were tested. The cytotoxicities of water, 50% ethanol and 95% ethanol extractions of RPM and RPMP were tested. HPLC-DAD analysis was carried to reveal the content change of TSG, physcion and emodin after the processing procedure. The TD(50) of TSG, physcion and emodin in MTT assay were >10,000 μM, 2853.61 μM and 520.37 μM. In the NRU assay, the TD(50) of TSG, physcion and emodin were much smaller (1401.53 μM, 1140.00 μM, and 3.80 μM). Emodin induced much severe liver enzyme secretion than TSG and physcion. Cell proliferation and LDH leakage rate showed no difference between RPM and RPMP extractions, but ALP, AST and ALT secretions in RPMP extractions were significant lower than that of PMR groups. Water extractions of RPM and RPMP were less toxic than any other solvent in most of the assays. Positive correlation was found between the TSG/emodin ratio and MTT survival rate. The emodin/physcion ratio also showed positive correlation with the LDH leakage percentage. CONCLUSIONS: In conclusion, Radix Polygonum multiflorum and Radix Polygonum multiflorum Praeparata were not liver injure inducing in our in vitro assays. However, the processing produce of RPM could reduce its effect on both cell proliferation and enzyme secretion of liver cell. Judging from cell proliferation, integrity of cell membrane and enzyme secretion, three major chemical constituents of RPM: TSG, physcion and emodin showed no, moderate and severe cytotoxicity against human liver cell line L-02 respectively. Chemical constituents-cytotoxicity relationship investigation revealed that TSG and physcion probably had attenuating effect to emodin. The attenuating mechanisms were still under investigation.

In vivo:

Restor Neurol Neurosci. 2013;31(1):41-52.

Tetrahydroxystilbene glucoside antagonizes age-related α-synuclein overexpression in the hippocampus of APP transgenic mouse model of Alzheimer's disease.[Pubmed: 23160059]

To investigate the mRNA and protein alterations of α-synuclein in the brain of Alzheimer's disease-like mouse model at the different ages, and to evaluate the effects of 2,3,5,4'-tetrahydroxy stilbene-2-O-β-D-glucoside ( 2,3,5,4'-Tetrahydroxyl diphenylethylene-2-O-glucoside,TSG) on α-synuclein expression.
METHODS AND RESULTS:
TSG (120 or 240 μmol kg(-1)d(-1)) was intragastrically administered to APPV717I transgenic (Tg) mice at 4- or 10-month-old for 6 months. mRNA expression of α-synuclein increased in hippocampus in 4 month to 16 month old Tg mice compared with age-matched control. α-synuclein protein expression in hippocampus also increased in 4 month to 16 month old Tg mice significantly. Significant down-regulation of α-synuclein mRNA and protein expression in hippocampus was found after treatment of TSG for 6 months in both 10- and 16-month-old Tg mice. Production of dimer and tetramer of α-synuclein protein in Tg mice was inhibited after treatment with TSG.
CONCLUSIONS:
The expression and aggregation of α-synuclein was age-dependently increased in Tg mice. TSG not only prevents over-expression of α-synuclein at an early stage, but also reverses the increased expression of α-synuclein and inhibits the aggregation at the late stage of Tg mice. TSG may have potential to the prevention and treatment of Alzheimer's diseases.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
Pinostilbenoside; Pinostilbenoside	CFN98995	58762-96-2	C₂₁H₂₄O₈ = 404.4	5mg	QQ客服：2159513211
3-羟基-5-甲氧基二苯乙烯; 5-Methoxy-3-stilbenol	CFN92587	5150-38-9	C₁₅H₁₄O₂ = 226.3	5mg	QQ客服：2159513211
Thunalbene; Thunalbene	CFN92783	220862-05-5	C₁₅H₁₄O₃ = 242.3	5mg	QQ客服：1413575084
3'-O-甲基山药素III; 3'-O-Methylbatatasin III	CFN91176	101330-69-2	C₁₆H₁₈O₃ = 258.3	10mg	QQ客服：1413575084
山药素 III; Batatasin III	CFN92689	56684-87-8	C₁₅H₁₆O₃ = 244.3	5mg	QQ客服：1457312923
山药素 IV; Batatasin IV	CFN95319	60347-67-3	C₁₅H₁₆O₃ = 244.3	5mg	QQ客服：1413575084
3-甲氧基-5-[2-(2-甲氧基苯基)乙基]苯酚; Stilbostemin N	CFN97863	1000676-45-8	C₁₆H₁₈O₃ = 258.32	5mg	QQ客服：3257982914
山药素 V; Batatasin V	CFN95320	65817-45-0	C₁₇H₂₀O₄ = 288.3	5mg	QQ客服：2159513211
紫檀芪; Pterostilbene	CFN90397	537-42-8	C₁₆H₁₆O₃ = 256.30	20mg	QQ客服：2056216494
3-羟基-4',5-二甲氧基二苯乙烯; 3-Hydroxy-4',5-dimethoxystilbene	CFN95199	58436-29-6	C₁₆H₁₆O₃ = 256.3	10mg	QQ客服：1457312923

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.4607 mL	12.3035 mL	24.6069 mL	49.2138 mL	61.5173 mL
5 mM	0.4921 mL	2.4607 mL	4.9214 mL	9.8428 mL	12.3035 mL
10 mM	0.2461 mL	1.2303 mL	2.4607 mL	4.9214 mL	6.1517 mL
50 mM	0.0492 mL	0.2461 mL	0.4921 mL	0.9843 mL	1.2303 mL
100 mM	0.0246 mL	0.123 mL	0.2461 mL	0.4921 mL	0.6152 mL

2,3,5,4-四羟基二苯乙烯葡萄糖苷

2,3,5,4'-Tetrahydroxyl diphenylethylene-2-O-glucoside

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