松茋

Pinostilbene

	产品编号	CFN98662
	CAS编号	42438-89-1
	分子式 = 分子量	C₁₅H₁₄O₃ = 242.3
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Phenols
	植物来源	The seeds of Vitis riparia.
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
松茋	CFN98662	42438-89-1	1mg	QQ客服：3257982914
松茋	CFN98662	42438-89-1	5mg	QQ客服：3257982914
松茋	CFN98662	42438-89-1	10mg	QQ客服：3257982914
松茋	CFN98662	42438-89-1	20mg	QQ客服：3257982914

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

University of Indonesia (Indonesia)

Center for protein Engineering (CIP) (Belgium)

Universidade Católica Portuguesa (Portugal)

Technical University of Denmark (Denmark)

Instituto Politécnico de Bragan?a (Portugal)

University of Madras (India)

Copenhagen University (Denmark)

Massachusetts General Hospital (USA)

Medical University of South Carolina (USA)

Rio de Janeiro State University (Brazil)

Universidade Federal de Goias (UFG) (Brazil)

Instituto de Investigaciones Agropecuarias (Chile)

Uniwersytet Jagielloński w Krakowie (Poland)

Heidelberg University (Germany)

More...

Description:

Pinostilbene has protective effects against 6-hydroxydopamine-induced neurotoxicity in SH-SY5Y cells, it can reduce release of lactate dehydrogenase and activity of caspase-3 triggered by 6-hydroxydopamine (6-OHDA) in a dose-dependent manner. Pinostilbene can significantly inhibit the growth of human colon cancer cells, i.e., HCT116 and HT29, 20 and 40 uM of pinostilbene causes cell cycle arrest at S phase and induces apoptosis in colon cancer cells.

Targets:

Caspase | JNK

In vitro:

J Nutr Biochem. 2010 Jun;21(6):482-9.

Protective effects of pinostilbene, a resveratrol methylated derivative, against 6-hydroxydopamine-induced neurotoxicity in SH-SY5Y cells.[Pubmed: 19443200]

Release of lactate dehydrogenase and activity of caspase-3 triggered by 6-OHDA were significantly reduced by resveratrol and one of the methylated derivatives, Pinostilbene (3,4'-dihydroxy-5-methoxystilbene), in a dose-dependent manner. In addition, Pinostilbene exerted a potent neuroprotective effect with a wider effective concentration range than resveratrol.
METHODS AND RESULTS:
By using high-performance liquid chromatography, we found that uptake of Pinostilbene into SH-SY5Y cells was significantly higher than that of resveratrol. Enhanced bioavailability may thus be a major factor contributing to the neuroprotective activity of Pinostilbene. Moreover, Western blot analysis demonstrated that Pinostilbene markedly attenuated the phosphorylation of JNK and c-Jun triggered by 6-OHDA. Besides, mammalian target of rapamycin kinase may be an intracellular target accounting for the neuroprotective effects of Pinostilbene.
CONCLUSIONS:
Our findings demonstrate the potential of methylated stilbenes in neuroprotection and provide important information for further research in this field.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
Thunalbene; Thunalbene	CFN92783	220862-05-5	C₁₅H₁₄O₃ = 242.3	5mg	QQ客服：2159513211
3'-O-甲基山药素III; 3'-O-Methylbatatasin III	CFN91176	101330-69-2	C₁₆H₁₈O₃ = 258.3	10mg	QQ客服：2159513211
山药素 III; Batatasin III	CFN92689	56684-87-8	C₁₅H₁₆O₃ = 244.3	5mg	QQ客服：2056216494
山药素 IV; Batatasin IV	CFN95319	60347-67-3	C₁₅H₁₆O₃ = 244.3	5mg	QQ客服：1457312923
3-甲氧基-5-[2-(2-甲氧基苯基)乙基]苯酚; Stilbostemin N	CFN97863	1000676-45-8	C₁₆H₁₈O₃ = 258.32	5mg	QQ客服：1457312923
山药素 V; Batatasin V	CFN95320	65817-45-0	C₁₇H₂₀O₄ = 288.3	5mg	QQ客服：3257982914
紫檀芪; Pterostilbene	CFN90397	537-42-8	C₁₆H₁₆O₃ = 256.30	20mg	QQ客服：1457312923
3-羟基-4',5-二甲氧基二苯乙烯; 3-Hydroxy-4',5-dimethoxystilbene	CFN95199	58436-29-6	C₁₆H₁₆O₃ = 256.3	10mg	QQ客服：2159513211
白藜芦醇三甲醚; Trimethoxystilbene	CFN90874	22255-22-7	C₁₇H₁₈O₃ = 270.3	20mg	QQ客服：2056216494
3,5-二甲氧基-3'-羟基联苄; 3,5-Dimethoxy-3'-hydroxybibenzyl	CFN89540	168281-05-8	C₁₆H₁₈O₃ = 258.31	5mg	QQ客服：1413575084

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	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	4.1271 mL	20.6356 mL	41.2712 mL	82.5423 mL	103.1779 mL
5 mM	0.8254 mL	4.1271 mL	8.2542 mL	16.5085 mL	20.6356 mL
10 mM	0.4127 mL	2.0636 mL	4.1271 mL	8.2542 mL	10.3178 mL
50 mM	0.0825 mL	0.4127 mL	0.8254 mL	1.6508 mL	2.0636 mL
100 mM	0.0413 mL	0.2064 mL	0.4127 mL	0.8254 mL	1.0318 mL