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  • 松茋

    • 松茋

    Pinostilbene

    松茋
    		产品编号 CFN98662
    CAS编号 42438-89-1
    分子式 = 分子量 C15H14O3 = 242.3
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Phenols
    植物来源 The seeds of Vitis riparia.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    松茋 CFN98662 42438-89-1 1mg QQ客服：2056216494
    松茋 CFN98662 42438-89-1 5mg QQ客服：2056216494
    松茋 CFN98662 42438-89-1 10mg QQ客服：2056216494
    松茋 CFN98662 42438-89-1 20mg QQ客服：2056216494
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学，并且还在增涨
  • University of Canterbury (New Zealand)
  • Medical University of Gdansk (Poland)
  • Institute of Chinese Materia Medica (China)
  • University of Wisconsin-Madison (USA)
  • Max-Planck-Insitut (Germany)
  • The Institute of Cancer Research (United Kingdom)
  • University of South Australia (Australia)
  • Chang Gung University (Taiwan)
  • University of Bordeaux (France)
  • The Ohio State University (USA)
  • Georgia Institute of Technology (USA)
  • Sanford Burnham Medical Research Institute (USA)
  • Sanford Burnham Prebys Medical Discovery Institute (USA)
  • Semmelweis Unicersity (Hungary)
  • More...
    • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Biol Pharm Bull.2020, 43(10):1534-1541.
  • Hong Kong Baptist University2023, 048330T.
  • Mol Med Rep.2014, 9(5):1653-9
  • Applied Biological Chemistry 2022, 65,5(2022).
  • Oncol Rep.2016, 35(3):1356-64
  • Molecules.2022, 27(2):451.
  • Antioxidants (Basel).2022, 11(12):2496.
  • Phytomedicine.2021, 84:153501.
  • Molecules.2018, 23(7):E1659
  • Biomed Chromatogr.2020, e5021.
  • Biol Pharm Bull.2018, 41(11):1645-1651
  • Food Chem.2021, 337:128023.
  • Molecules.2022, 27(21):7514.
  • BMC Complement Altern Med.2019, 19(1):339
  • J.Korean Society of Grassland&Forage Science2023, 43(3):138-147.
  • Molecules.2023, 28(13):4907.
  • Evid Based Complement Alternat Med.2021, 8707280.
  • Chemistry of Plant Materials.2019, 215-222
  • Anal Chim Acta.2021, 1180:338874.
  • J Biomol Struct Dyn.2023, 1-21.
  • Dis Markers.2022, 2022:2380879.
  • University of Stuttgart2021, 11682.
  • Evid Based Complement Alternat Med.2018, 2018:4259603
  • ...
    • 生物活性
    Description: Pinostilbene has protective effects against 6-hydroxydopamine-induced neurotoxicity in SH-SY5Y cells, it can reduce release of lactate dehydrogenase and activity of caspase-3 triggered by 6-hydroxydopamine (6-OHDA) in a dose-dependent manner. Pinostilbene can significantly inhibit the growth of human colon cancer cells, i.e., HCT116 and HT29, 20 and 40 uM of pinostilbene causes cell cycle arrest at S phase and induces apoptosis in colon cancer cells.
    Targets: Caspase | JNK
    In vitro:
    J Nutr Biochem. 2010 Jun;21(6):482-9.
    Protective effects of pinostilbene, a resveratrol methylated derivative, against 6-hydroxydopamine-induced neurotoxicity in SH-SY5Y cells.[Pubmed: 19443200]
    Release of lactate dehydrogenase and activity of caspase-3 triggered by 6-OHDA were significantly reduced by resveratrol and one of the methylated derivatives, Pinostilbene (3,4'-dihydroxy-5-methoxystilbene), in a dose-dependent manner. In addition, Pinostilbene exerted a potent neuroprotective effect with a wider effective concentration range than resveratrol.
    METHODS AND RESULTS:
    By using high-performance liquid chromatography, we found that uptake of Pinostilbene into SH-SY5Y cells was significantly higher than that of resveratrol. Enhanced bioavailability may thus be a major factor contributing to the neuroprotective activity of Pinostilbene. Moreover, Western blot analysis demonstrated that Pinostilbene markedly attenuated the phosphorylation of JNK and c-Jun triggered by 6-OHDA. Besides, mammalian target of rapamycin kinase may be an intracellular target accounting for the neuroprotective effects of Pinostilbene.
    CONCLUSIONS:
    Our findings demonstrate the potential of methylated stilbenes in neuroprotection and provide important information for further research in this field.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 4.1271 mL 20.6356 mL 41.2712 mL 82.5423 mL 103.1779 mL
    5 mM 0.8254 mL 4.1271 mL 8.2542 mL 16.5085 mL 20.6356 mL
    10 mM 0.4127 mL 2.0636 mL 4.1271 mL 8.2542 mL 10.3178 mL
    50 mM 0.0825 mL 0.4127 mL 0.8254 mL 1.6508 mL 2.0636 mL
    100 mM 0.0413 mL 0.2064 mL 0.4127 mL 0.8254 mL 1.0318 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    二氢藜芦醇; Dihydroresveratrol CFN98987 58436-28-5 C14H14O3 = 230.3 20mg QQ客服：3257982914
    白藜芦醇 12-C-beta-葡萄糖苷; Resveratrol 12-C-beta-glucopyranoside CFN95783 163527-00-2 C20H22O8 = 390.4 10mg QQ客服：1457312923
    二氢白藜芦醇3-O-葡萄糖甙; Dihydroresveratrol 3-O-glucoside CFN99021 100432-87-9 C20H24O8 = 392.4 5mg QQ客服：3257982914
    去氧土大黄苷元; Desoxyrhapontigenin CFN90854 33626-08-3 C15H14O3 = 242.3 20mg QQ客服：1457312923
    去氧土大黄苷; Desoxyrhaponticin CFN90911 30197-14-9 C21H24O8 = 404.4 20mg QQ客服：3257982914
    土大黄苷 6''-O-没食子酸酯; Rhaponticin 6''-O-gallate CFN91099 94356-23-7 C28H28O13 = 572.51 5mg QQ客服：215959384
    土大黄苷 2''-O-没食子酸酯; Rhaponticin 2''-O-gallate CFN91100 94356-24-8 C28H28O13 = 572.51 5mg QQ客服：1413575084
    2,3,5,4-四羟基二苯乙烯葡萄糖苷; 2,3,5,4'-Tetrahydroxyl diphenylethylene-2-O-glucoside CFN99995 82373-94-2 C20H22O9 = 406.39 20mg QQ客服：2159513211
    松茋; Pinostilbene CFN98662 42438-89-1 C15H14O3 = 242.3 5mg QQ客服：215959384
    1-(3',5'-dimethoxy)phenyl-2-[4''-O-beta-D-glucopyranosyl (6→1)-O-α-L-rhamnopyranosyl]phenylethane; 1-(3',5'-dimethoxy)phenyl-2-[4''-O-beta-D-glucopyranosyl (6->1)-O-alpha-L-rhamnopyranosyl]phenylethane CFN95285 1338076-61-1 C28H38O12 = 566.6 5mg QQ客服：2056216494

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