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  • 齐墩果-12-烯-3b,6b-二醇

    12-Oleanene-3,6-diol

    齐墩果-12-烯-3b,6b-二醇
    产品编号 CFN94009
    CAS编号 41498-79-7
    分子式 = 分子量 C30H50O2 = 442.72
    产品纯度 >=98%
    物理属性 Cryst.
    化合物类型 Triterpenoids
    植物来源 The herbs of Celastrus orbiculatus Thunb.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    齐墩果-12-烯-3b,6b-二醇 CFN94009 41498-79-7 1mg QQ客服:1457312923
    齐墩果-12-烯-3b,6b-二醇 CFN94009 41498-79-7 5mg QQ客服:1457312923
    齐墩果-12-烯-3b,6b-二醇 CFN94009 41498-79-7 10mg QQ客服:1457312923
    齐墩果-12-烯-3b,6b-二醇 CFN94009 41498-79-7 20mg QQ客服:1457312923
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • FORTH-IMBB (Greece)
  • Universidade do Porto (Portugal)
  • Weizmann Institute of Science (Israel)
  • Uniwersytet Gdański (Poland)
  • Aveiro University (Portugal)
  • Macau University of Science and Technology (China)
  • Lund University (Sweden)
  • University of Oslo (Norway)
  • Universidade Católica Portuguesa (Portugal)
  • Chiang Mai University (Thailand)
  • Molecular Biology Institute of Barcelona (IBMB)-CSIC (Spain)
  • Harvard University (USA)
  • Almansora University (Egypt)
  • Chinese University of Hong Kong (China)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Antioxidants (Basel).2022, 11(12):2411.
  • J Appl Microbiol.2022, 132(2):949-963.
  • Molecules 2022, 27(3),1047.
  • Int J Mol Sci.2017, 18(12)
  • Molecular & Cellular Toxicology2017, 13(3):271-278
  • Chem Biol Interact.2020, 328:109200.
  • Life Sci.2021, 286:120019.
  • BMC Plant Biol.2018, 18(1):122
  • Front Plant Sci.2022, 13:982771.
  • Biomol Ther (Seoul).2020, 28(6):542-548.
  • Naunyn Schmiedebergs Arch Pharmacol.2021, 394(1):107-115.
  • Antioxidants.2022, 11(3):592.
  • Heliyon2020, 6(6):e04337.
  • J Nat Prod.2015, 78(6):1339-4
  • J Cell Mol Med . 2023, jcmm.17954.
  • The Korea Journal of Herbology2019, 34(2):25-32
  • Advances in Traditional Medicine 2021, 21:779-789.
  • Plants (Basel).2023, 12(1):163.
  • J Nat Prod.2021, 84(9):2544-2553.
  • Antioxidants (Basel).2020, 9(4):284.
  • Cell Chem Biol.2019, 26(1):27-34
  • Life Sci.2019, 216:259-270
  • Lab Chip.2018, 18(6):971-978
  • ...
  • 生物活性
    Description: 12-Oleanene-3,6-diol has antitumor activity, it can induce apoptosis and has inhibition effect on the proliferation in RKO cell line.
    In vitro:
    China journal of Chinese materia medica, 2006, 31(17):1450-1453.
    Antitumor effects of novel triterpene from Celastrus hypoleucus on human colorectal cancer cell line RKO in vitro.[Reference: WebLink]
    To investigate the effects of novel triterpene (12-Oleanene-3,6-diol ) from Celastrus hypoleucus on the proliferation and apoptosis of human colorectal cancer cell line RKO.
    METHODS AND RESULTS:
    The inhibitory effect of the novel triterpene on RKO cell proliferation was assayed by MTT dye reduction. The morphology of apoptotic cells was observed with AO/EB double fluorescence staining and HE staining, DNA fragment with electrophoresis on agarose gels, sub-diploid peak and cell cycle with flow cytometer (FCM). Novel triterpene (12-Oleanene-3,6-diol) from C. hypoleucus significantly inhibited proliferation of RKO cells in dose-dependent and time-dependent manner, the IC50 was (12.20 +/- 0.79) microg x mL(-1) at 48 h. Typical apoptotic changes were observed in RKO cells under the fluorescence microscope and the light microscope. DNA ladder was detected on agarose gels at concentrations from 10 microg x mL(-1) to 20 microg x mL(-1) at 48 h. With FCM methods, dose-dependent apoptosis-induced effect was observed in RKO cell line after treatment of triterpene for 48 h, and the apoptotic rates were increased from(2.93 +/- 0.84) % to (50.79 +/- 6.61) % at concentrations from 2.5 microg x mL(-1) to 20 microg x mL(-1). DNA histograms data from FCM analysis showed that the number of cells was obviously reduced during G0-G1 phase and G2-M phase, but not during S phase for RKO cell line after treatment with various concentrations of the triterpene for 48 hours.
    CONCLUSIONS:
    Novel triterpene (12-Oleanene-3,6-diol) from C. hypoleucus can induce apoptosis and has inhibition effect on the proliferation in RKO cell line.
    International Journal of Gynecological Cancer, 2012, 22(1):38-42.
    Oleanen induces apoptosis of cervical cancer cells by up-regulation of Bim.[Reference: WebLink]
    Plants belonging to the genus Celastrus exhibit antitumor activity and the ability to reverse multidrug resistance in tumor cells; however, it remains unclear whether the compound oleanen from Celastrus hypoleucus also exhibits antitumor activity. The objective of this study was to explore the inhibitory effect of 12-oleanene-3β, 6α-diol (12-Oleanene-3,6-diol, oleanen) on the proliferation of cervical cancer HeLa cells in vitro, as well as its relative mechanism.
    METHODS AND RESULTS:
    HeLa cells were treated with different concentrations of oleanen for different times. Cell proliferation was determined by 3-(4,5)-dimethylthiahiazo (-z-y1)-3,5-di-phenytetrazoliumromide assay. Cell apoptosis was evaluated by flow cytometry and caspases activities assay. The expression of several proapoptotic proteins belonging to the Bcl-2 family, such as Bax, Bim, and Bad, was detected by Western blot. RESULTS:Oleanen mainly inhibited the proliferation of HeLa cells at the G0 to G1 and G2 to M phases, and the IC50 of oleanen for cells was significantly higher at 24 hours compared to 48 hours (17.45 ± 3.71 vs 9.02 ± 0.83 μg/mL, respectively; P < 0.05). The significant increase in activity of caspase 3/7, caspase 6 in oleanen-treated HeLa cells indicated that oleanen promoted the apoptosis of HeLa cells. The activity of caspase 9 representing the endogenous apoptotic pathways also increased obviously in oleanen treatment. Furthermore, the increase in the expression of Bim was the most significant among the Bcl-2 family after oleanen treatment.
    CONCLUSIONS:
    Oleanen up-regulates the expression of Bim and other proapoptotic molecules to activate the endogenous apoptosis pathway, thus promoting apoptosis and inhibiting proliferation of human cervical cancer HeLa cells in vitro.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.2588 mL 11.2938 mL 22.5876 mL 45.1753 mL 56.4691 mL
    5 mM 0.4518 mL 2.2588 mL 4.5175 mL 9.0351 mL 11.2938 mL
    10 mM 0.2259 mL 1.1294 mL 2.2588 mL 4.5175 mL 5.6469 mL
    50 mM 0.0452 mL 0.2259 mL 0.4518 mL 0.9035 mL 1.1294 mL
    100 mM 0.0226 mL 0.1129 mL 0.2259 mL 0.4518 mL 0.5647 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    9(11),12-齐墩果二烯-3beta-醇; 9(11),12-Oleanadien-3-ol CFN97528 94530-87-7 C30H48O = 424.7 5mg QQ客服:1457312923
    齐墩果-12-烯-3b,6b-二醇; 12-Oleanene-3,6-diol CFN94009 41498-79-7 C30H50O2 = 442.72 5 mg QQ客服:215959384
    曼陀罗萜醇酮; Daturaolone CFN94010 41498-80-0 C30H48O2 = 440.71 5 mg QQ客服:215959384
    黑果茜草萜 B ; Rubiprasin B CFN96835 125263-66-3 C32H52O4 = 500.76 5mg QQ客服:3257982914
    黑果茜草萜 A ; Rubiprasin A CFN96836 125263-65-2 C32H52O5 = 516.76 5mg QQ客服:3257982914
    13(18)-齐墩果烯-3-醇,Α-香树素; 13(18)-Oleanen-3-ol CFN98801 508-04-3 C30H50O = 426.7 5mg QQ客服:2056216494
    乙酸-delta-香树精酯; delta-Amyrin acetate CFN98820 51361-60-5 C32H52O2 = 468.8 5mg QQ客服:2056216494
    13(18)-齐墩果烯-3-酮,Α-香树脂酮; 13(18)-Oleanen-3-one CFN98023 20248-08-2 C30H48O = 424.7 5mg QQ客服:1413575084
    台湾牛奶菜双氧甾甙 B; Marsformoxide B CFN96397 2111-46-8 C32H50O3 = 482.8 5mg QQ客服:2056216494
    (3beta,11alpha,12alpha,13alpha)-11,12-环氧-13-甲基-27-去甲齐墩果-14-烯-3-醇十六烷酸酯 ; 11alpha,12alpha-Oxidotaraxerol palmitate CFN96827 495389-95-2 C46H78O3 = 679.11 5mg QQ客服:2159513211

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