大豆甾醇A

Soyasapogenol A

	产品编号	CFN93150
	CAS编号	508-01-0
	分子式 = 分子量	C₃₀H₅₀O₄ = 474.7
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Triterpenoids
	植物来源	The seeds of Glycine max
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
大豆甾醇A	CFN93150	508-01-0	1mg	QQ客服：215959384
大豆甾醇A	CFN93150	508-01-0	5mg	QQ客服：215959384
大豆甾醇A	CFN93150	508-01-0	10mg	QQ客服：215959384
大豆甾醇A	CFN93150	508-01-0	20mg	QQ客服：215959384

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Description:

Soyasapogenol A shows estrogenic and hepatoprotective activities, it directly prevents apoptosis of hepatocytes, and secondly, inhibits the elevation of plasma TNF-α, which consequently resulted in the prevention of liver damage in the concanavalin A-induced hepatitis model.

Targets:

TNF-α

In vitro:

J Agric Food Chem. 2008 Apr 23;56(8):2603-8.

Effect of soyasapogenol A and soyasapogenol B concentrated extracts on HEP-G2 cell proliferation and apoptosis.[Pubmed: 18361499 ]

METHODS AND RESULTS:
The growth inhibition and the induction of apoptosis brought about by soyasaponins extracted from soy flour ( Glycine max (L.)) and concentrated for soyasapogenols A and B formed by hydrolysis were tested for cytoactivity in the human hepatocellular carcinoma cell line Hep-G2. Concentrated soyasapogenol A (SG-A) and soyasapogenol B (SG-B) extracts contained approximately 69.3% and 46.2% of their respective aglycones (soyasapogenols) assessed by HPLC and ESI-MS, while the soyasaponin extract (TS), derived from crude methanol extraction, did not contain any detectable amounts of SG-A or SG-B. An MTT viability assay showed that all three extracts had an effect on Hep-G2 proliferation in a dose-response manner with 72 h LC50 values of 0.594+/-0.021 mg/mL for TS, 0.052+/-0.011 mg/mL for SG-A, and 0.128+/-0.005 mg/mL for SG-B. Apoptotic cells were determined by flow cytometry cell cycle analysis and confocal laser scanning microscopy (CLSM). Cell cycle analysis indicated a significant ( P< 0.05) greater sub-G1 buildup of apoptotic cells at 24 h (25.63+/-2.1%) and 72 h (47.1+/-3.5%) for the SG-A extract compared to SG-B, whereas the TS extract produced only a minor buildup of sub-G1 cells. CLSM confirmed a morphological change of all treatments after 24 h, at the respective LC50 concentrations.
CONCLUSIONS:
These results show that the samples that contained mainly soyasapogenols A and B showed a greater ability to inhibit proliferation of cultured Hep-G2 when compared to a total soyasaponin extract that did not contain any soyasapogenols.

In vivo:

Eur J Pharmacol. 2000 Mar 10;391(1-2):175-81.

Protective effects of soyasapogenol A on liver injury mediated by immune response in a concanavalin A-induced hepatitis model.[Pubmed: 10720649]

The present study was carried out to analyze the effects of soyasapogenol A on the liver injury mediated by the immune response in concanavalin A-induced hepatitis in mice.
METHODS AND RESULTS:
Soyasapogenol A reduced the number of infiltrating inflammatory cells in the liver and significantly lowered the elevated level of plasma tumor necrosis factor-alpha (TNF-alpha) 2 h after concanavalin A treatment, and then markedly reduced the elevated plasma alanine aminotransferase activity and decreased the number of apoptotic bodies in the liver parenchymal cells but not in the sinusoidal cells at 24 h.
CONCLUSIONS:
Since the effect of soyasapogenol A on the elevated plasma TNF-alpha level was not appreciable compared to the preventive effect of soyasapogenol A on the elevated plasma alanine aminotransferase level, these results suggest that soyasapogenol A directly prevents apoptosis of hepatocytes, and secondly, inhibits the elevation of plasma TNF-alpha, which consequently resulted in the prevention of liver damage in the concanavalin A-induced hepatitis model.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
日耳曼醇; Germanicol	CFN89221	465-02-1	C₃₀H₅₀O = 426.72	5mg	QQ客服：3257982914
Germanicol acetate ; Germanicol acetate	CFN96961	10483-91-7	C₃₂H₅₂O₂ = 468.76	5mg	QQ客服：1457312923
beta-香树脂醇乙酸酯; beta-Amyrin acetate	CFN99679	1616-93-9	C₃₂H₅₂O₂ = 468.8	5mg	QQ客服：2159513211
beta-软脂酸香树精酯; beta-Amyrin palmitate	CFN97009	5973-06-8	C₄₆H₈₀O₂ = 665.1	5mg	QQ客服：1413575084
beta-白檀酮; beta-Amyrone	CFN97099	638-97-1	C₃₀H₄₈O = 424.7	5mg	QQ客服：2056216494
9(11),12-齐墩果二烯-3beta-醇; 9(11),12-Oleanadien-3-ol	CFN97528	94530-87-7	C₃₀H₄₈O = 424.7	5mg	QQ客服：3257982914
齐墩果-12-烯-3b,6b-二醇; 12-Oleanene-3,6-diol	CFN94009	41498-79-7	C₃₀H₅₀O₂ = 442.72	5 mg	QQ客服：215959384
曼陀罗萜醇酮; Daturaolone	CFN94010	41498-80-0	C₃₀H₄₈O₂ = 440.71	5 mg	QQ客服：1413575084
黑果茜草萜 B ; Rubiprasin B	CFN96835	125263-66-3	C₃₂H₅₂O₄ = 500.76	5mg	QQ客服：3257982914
黑果茜草萜 A ; Rubiprasin A	CFN96836	125263-65-2	C₃₂H₅₂O₅ = 516.76	5mg	QQ客服：2056216494

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.1066 mL	10.533 mL	21.0659 mL	42.1319 mL	52.6648 mL
5 mM	0.4213 mL	2.1066 mL	4.2132 mL	8.4264 mL	10.533 mL
10 mM	0.2107 mL	1.0533 mL	2.1066 mL	4.2132 mL	5.2665 mL
50 mM	0.0421 mL	0.2107 mL	0.4213 mL	0.8426 mL	1.0533 mL
100 mM	0.0211 mL	0.1053 mL	0.2107 mL	0.4213 mL	0.5266 mL

大豆甾醇A

Soyasapogenol A

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