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  • beta-香树脂醇乙酸酯

    beta-Amyrin acetate

    beta-香树脂醇乙酸酯
    产品编号 CFN99679
    CAS编号 1616-93-9
    分子式 = 分子量 C32H52O2 = 468.8
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Triterpenoids
    植物来源 The herbs of Alstonia boonei.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
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    产品名称 产品编号 CAS编号 包装 QQ客服
    beta-香树脂醇乙酸酯 CFN99679 1616-93-9 1mg QQ客服:215959384
    beta-香树脂醇乙酸酯 CFN99679 1616-93-9 5mg QQ客服:215959384
    beta-香树脂醇乙酸酯 CFN99679 1616-93-9 10mg QQ客服:215959384
    beta-香树脂醇乙酸酯 CFN99679 1616-93-9 20mg QQ客服:215959384
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Sanford Burnham Prebys Medical Discovery Institute (USA)
  • Subang Jaya Medical Centre (Malaysia)
  • National Chung Hsing University (Taiwan)
  • Sanford Burnham Medical Research Institute (USA)
  • University of Maryland School of Medicine (USA)
  • Regional Crop Research Institute (Korea)
  • Mahidol University (Thailand)
  • Tohoku University (Japan)
  • Max Rubner-Institut (MRI) (Germany)
  • Tokyo Woman's Christian University (Japan)
  • VIB Department of Plant Systems Biology, UGent (PSB) (Belgium)
  • Stanford University (USA)
  • Kitasato University (Japan)
  • University of Amsterdam (Netherlands)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Molecules.2020, 25(23):5556.
  • Bioengineering2023, 10(10), 1113.
  • J Nat Prod.2021, 84(9):2544-2553.
  • Int J Vitam Nutr Res.2022, doi: 10.1024.
  • Phytochemistry2018, 15:83-92
  • Evid Based Complement Alternat Med.2022, 2022:1307173.
  • Archives of Biological sciences2022, 00:21-21
  • Food Research International2020, 108987
  • Int J Mol Sci.2021, 22(9):5012.
  • South African J of Plant&Soil2018, 29-32
  • J Agric Food Chem.2020, 68(51):15164-15175
  • Heliyon.2022, e12337.
  • J Korean Med Ophthalmol Otolaryngol Dermatol2023, 36(1):1-20.
  • Molecules.2020, 25(18),4089.
  • J Ethnopharmacol.2022, 291:115159.
  • ACS Omega2020, 5,33,20825-20830
  • PLoS One.2018, 13(11):e0208055
  • J. Food Composition and Anal.2022, V 109:104482.
  • J Ethnopharmacol.2020, 254:112733.
  • LWT2020, 124:109163
  • Food Sci Nutr.2023, 00:1-10.
  • J Nat Med.2021, doi: 10.1007.
  • BMC Complement Altern Med.2019, 19(1):11
  • ...
  • 生物活性
    Description: beta-Amyrin acetate has anti-inflammatory, antioxidant, and antidyslipidemic activities, it shows significant HMG-CoA-reductase and sEH inhibition. beta-Amyrin acetate also exhibits weak-moderate antiproliferative activity against the A2780 human ovarian cancer cell line.
    Targets: Immunology & Inflammation related
    In vitro:
    Food Chem Toxicol. 2014 Feb;64:225-30.
    Discovery of soluble epoxide hydrolase inhibitors from natural products.[Pubmed: 24309146]
    With the goal of developing soluble epoxide hydrolase (sEH) inhibitors with novel chemical structures, the sEH inhibitory activities of 30 natural compounds were evaluated using both a fluorescent substrate, 3-phenyl-cyano(6-methoxy-2-naphthalenyl)methyl ester- 2-oxiraneacetic acid, and a physiological substrate, 14,15-epoxyeicosatrienoic acid.
    METHODS AND RESULTS:
    To evaluate the selectivity of sEH inhibition, the inhibition of microsomal epoxide hydrolase (mEH), which plays a critical role in detoxification of toxic epoxides, was determined using human liver microsomes. Honokiol and β-amyrin acetate, isolated from Magnolia officinalis and Acer mandshuricum, respectively, displayed strong inhibition of sEH activity, with respective IC50 values of 0.57 μM and 3.4 μM determined using the fluorescent substrate, and 1.7 μM and 6.1 μM determined using 14,15-epoxyeicosatrienoic acid. mEH activity was decreased to 49% or 61% of control activity by 25 μM honokiol or β-amyrin acetate, respectively.
    CONCLUSIONS:
    These results suggest that β-amyrin acetate and honokiol exhibit sEH inhibitory activity, although their sEH selectivity should be improved.
    Asian Pac J. Trop. Biomed., 2012, 2(2):S981–S4.
    Antioxidant and Cytotoxicity of β-Amyrin acetate fraction from Bridelia ferruginea Leaves.[Reference: WebLink]
    The objective of this work was to determine the beta-Amyrin acetate fraction in leave extract of Bridelia ferruginea and evaluate for its antioxidant and cytotoxicity potentials.
    METHODS AND RESULTS:
    The dried and pulverized leaves of Bridelia ferruginea was extracted with hexane and then with ethyl acetate. The concentrated ethylacetate extract subjected to silica gel column chromatography and eluted with a mixture of equal volume of hexane and dichloromethane afforded two major fractions. The more polar fraction was concentrated and subjected to GCMS analysis which afforded the steroid, 12-Oleanen-3yl acetate commonly known as beta-Amyrin acetate (66.14%). Its ability to act as a scavenger of DPPH radical and its cytotoxicity potential based on brine shrimp assay were investigated. The DPPH antioxidant assay revealed that the fraction had a higher antioxidant potential with an IC50 value of 158.2μg/mL relative to gallic acid which had IC50 of 201.1 μg/mL. The cytotoxicity assay using the brine shrimp a gave LC50 values of 319 and 5.86 μg/mL for acute and lethal doses respectively indicating extreme toxicity when compared to reference drug, cyclophosphamide which had LC50 value of 2506 μg/mL.
    CONCLUSIONS:
    Thus, the beta-Amyrin acetate has been identified for the first time in the leave of Bridelia ferruginea. The data here suggest that the beta-Amyrin acetate fraction of the leave of Bridelia ferruginea could be further explored in biological profiling requiring antioxidant and cytotoxic dependent therapeutics as the plant could be a viable source of antioxidant and cytotoxic agents in cancer chemotherapy in the near future.
    Pharm Biol. 2014 Nov;52(11):1478-86.
    beta-Amyrin and alpha-amyrin acetate isolated from the stem bark of Alstonia boonei display profound anti-inflammatory activity.[Pubmed: 25026352]
    To investigate the anti-inflammatory potential of beta-Amyrin acetateand α-amyrin acetate isolated from the stem bark of Alstonia boonei using animal models.
    METHODS AND RESULTS:
    Chromatographic purification of the crude methanol extract led to the isolation and structure elucidation of beta-Amyrin acetate and α-amyrin acetate.Both beta-Amyrin acetate and α-amyrin acetate inhibited heat-induced hemolysis to as much 47.2 and 61.5%, respectively, while diclofenac sodium (100 μg/mL) evoked only 40.5% inhibition. Both compounds at 100 µg/ear produced significant (p < 0.01) inhibition of ear edema in mice by 39.4 and 55.5%, respectively. Also at 100 mg/kg (p.o.) α-amyrin acetate evoked 60.3% reduction in total leucocyte count and significant (p < 0.05) suppression (47.9%) of neutrophil infiltration.
    CONCLUSIONS:
    This study generally provided evidence of profound anti-inflammatory activity of beta-Amyrin acetate and α-amyrin acetate isolated from the Alstonia boonei stem bark.
    In vivo:
    Phytomedicine. 2012 Jun 15;19(8-9):682-5.
    β-Amyrin acetate and β-amyrin palmitate as antidyslipidemic agents from Wrightia tomentosa leaves.[Pubmed: 22541636]
    The ethanolic extract and fractions of Wrightia tomentosa Roem. & Schult (Apocynaceae) leaves were tested in vivo for their antidyslipidemic activity in high fat diet (HFD) induced dyslipidemic hamsters.
    METHODS AND RESULTS:
    Activity guided isolation resulted in identification of antidyslipidemic compounds beta-Amyrin acetate and β-AP. Compounds beta-Amyrin acetate and β-AP decrease the levels of LDL by 36% and 44%, and increase the HDL-C/TC ratio by 49% and 28%, respectively, at a dose of 10mg/kg. In addition, the isolated compounds beta-Amyrin acetate and β-AP showed significant HMG-CoA-reductase inhibition, which was further established by docking studies.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.1331 mL 10.6655 mL 21.3311 mL 42.6621 mL 53.3276 mL
    5 mM 0.4266 mL 2.1331 mL 4.2662 mL 8.5324 mL 10.6655 mL
    10 mM 0.2133 mL 1.0666 mL 2.1331 mL 4.2662 mL 5.3328 mL
    50 mM 0.0427 mL 0.2133 mL 0.4266 mL 0.8532 mL 1.0666 mL
    100 mM 0.0213 mL 0.1067 mL 0.2133 mL 0.4266 mL 0.5333 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    beta-香树脂醇乙酸酯; beta-Amyrin acetate CFN99679 1616-93-9 C32H52O2 = 468.8 5mg QQ客服:2159513211
    beta-软脂酸香树精酯; beta-Amyrin palmitate CFN97009 5973-06-8 C46H80O2 = 665.1 5mg QQ客服:1413575084
    beta-白檀酮; beta-Amyrone CFN97099 638-97-1 C30H48O = 424.7 5mg QQ客服:3257982914
    9(11),12-齐墩果二烯-3beta-醇; 9(11),12-Oleanadien-3-ol CFN97528 94530-87-7 C30H48O = 424.7 5mg QQ客服:1457312923
    齐墩果-12-烯-3b,6b-二醇; 12-Oleanene-3,6-diol CFN94009 41498-79-7 C30H50O2 = 442.72 5 mg QQ客服:1413575084
    曼陀罗萜醇酮; Daturaolone CFN94010 41498-80-0 C30H48O2 = 440.71 5 mg QQ客服:2056216494
    黑果茜草萜 B ; Rubiprasin B CFN96835 125263-66-3 C32H52O4 = 500.76 5mg QQ客服:3257982914
    黑果茜草萜 A ; Rubiprasin A CFN96836 125263-65-2 C32H52O5 = 516.76 5mg QQ客服:2159513211
    13(18)-齐墩果烯-3-醇,Α-香树素; 13(18)-Oleanen-3-ol CFN98801 508-04-3 C30H50O = 426.7 5mg QQ客服:2159513211
    乙酸-delta-香树精酯; delta-Amyrin acetate CFN98820 51361-60-5 C32H52O2 = 468.8 5mg QQ客服:3257982914

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