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  • 1,6-O,O-二乙酰大花旋覆花内酯

    1,6-O,O-Diacetylbritannilactone

    1,6-O,O-二乙酰大花旋覆花内酯
    产品编号 CFN89518
    CAS编号 1286694-67-4
    分子式 = 分子量 C19H26O6 = 350.40
    产品纯度 >=98%
    物理属性 Cryst.
    化合物类型 Sesquiterpenoids
    植物来源 The flower heads of Inula britannica.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    1,6-O,O-二乙酰大花旋覆花内酯 CFN89518 1286694-67-4 1mg QQ客服:1457312923
    1,6-O,O-二乙酰大花旋覆花内酯 CFN89518 1286694-67-4 5mg QQ客服:1457312923
    1,6-O,O-二乙酰大花旋覆花内酯 CFN89518 1286694-67-4 10mg QQ客服:1457312923
    1,6-O,O-二乙酰大花旋覆花内酯 CFN89518 1286694-67-4 20mg QQ客服:1457312923
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Monash University Sunway Campus (Malaysia)
  • Chiang Mai University (Thailand)
  • Max-Planck-Insitut (Germany)
  • University Medical Center Mainz (Germany)
  • Universiti Malaysia Pahang (Malaysia)
  • Aarhus University (Denmark)
  • John Innes Centre (United Kingdom)
  • Instituto Politécnico de Bragan?a (Portugal)
  • Technical University of Denmark (Denmark)
  • Utah State University (USA)
  • University of Hertfordshire (United Kingdom)
  • Korea Intitute of Science and Technology (KIST) (Korea)
  • Universidade Federal de Santa Catarina (Brazil)
  • Michigan State University (USA)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Int J Food Sci Nutr.2019, 70(7):825-833
  • Agriculture2022, 12(2),227.
  • Bioorg Med Chem.2020, 28(12):115553.
  • Plants (Basel).2021, 10(2):278.
  • Appl. Sci. 2021, 11(1),14.
  • Front Pharmacol.2022, 13:806869.
  • Biomed Chromatogr.2019, 8:e4774
  • Nat Prod Sci.2018, 24(2):109-114
  • Molecules 2022, 27(3),1047.
  • Korean J. Food Preserv. 2021, 28(6):846-856.
  • Integr Cancer Ther.2018, 17(3):832-843
  • Int J Mol Sci.2018, 19(9):E2825
  • J Nat Prod.2021, 84(9):2544-2553.
  • Univerzita Karlova2022, 173245.
  • Russian J Bioorganic Chemistry 2021, 47:1411-1417.
  • Plants (Basel).2022, 11(21):2947.
  • Universidade Estadual Paulista2017, 42785
  • Evid Based Complement Alternat Med.2019, 2019:2135351
  • Appl. Sci.2021, 11(1),14.
  • Chem Biol Interact.2019, 298:1-7
  • Sci Rep.2019, 9(1):4342
  • Phytother Res.2016, 30(12):2020-2026
  • Pharm Biol.2016, 54(7):1255-62
  • ...
  • 生物活性
    Description: 1,6-O,O-Diacetylbritannilactone(OODBL) has anti-inflammatory activity, it has a potential therapeutic efficacy on inflammatory diseases especially allergic airway disease as a lead compound. OODBL has anti-asthmatic activity, it reduces leukotriene C4 production and degranulation through the suppression of cytosolic phospholipase A2 phosphorylation and phospholipase Cγ-mediated Ca2+ influx in IgE/antigen-stimulated BMMCs. OODBL also exhibits potent antitumor activity against several human cancer cell lines.
    Targets: IL Receptor | STAT | JAK | PARP | ROS | JNK | MAPK | Caspase
    In vitro:
    Inflammation. 2017 Dec;40(6):1967-1974
    1,6-O,O-Diacetylbritannilactone Inhibits Eotaxin-1 and ALOX15 Expression Through Inactivation of STAT6 in A549 Cells.[Pubmed: 28770377]
    1,6-O,O-Diacetylbritannilactone (OODBL), a plant sesquiterpene lactone, was previously reported to show multiple pharmacological effects such as anti-cancer and anti-inflammatory activities.
    METHODS AND RESULTS:
    In this study, we investigated the anti-inflammatory effect of OODBL on interleukin (IL)-4-induced signal transducer and activator of transcription 6 (STAT6) signaling pathway in human lung A549 cells. We found that OODBL dramatically inhibited IL-4-induced messenger RNA (mRNA) expression of eotaxin-1 and arachidonate 15-lipoxygenase-1 (ALOX15) in a dose-dependent manner. To clarify the action mechanism of OODBL, we examined the effect of OODBL on activation of STAT6. OODBL decreased both STAT6 phosphorylation and reporter gene activity. Furthermore, OODBL suppressed phosphorylation of Janus Kinase 3 (JAK3) without affecting JAK1.
    CONCLUSIONS:
    Taken together, OODBL abolished IL-4-induced eotaxin-1 and ALOX15 mRNA expressions by repressing the activation of STAT6 and JAK3. These results suggest that OODBL has a potential therapeutic efficacy on inflammatory diseases especially allergic airway disease as a lead compound.
    Nat Prod Commun. 2016 Jan;11(1):7-10.
    Cytotoxic and Pro-apoptotic Activities of Sesquiterpene Lactones from Inula britannica.[Pubmed: 26996005]

    METHODS AND RESULTS:
    In this study, five known sesquiterpene lactones (STL) with an α-methylene-γ-lactone motif, including two eudesmanolides, 1β-hydroxyalantolactone (1) and ivangustin (2), and three 1,10-seco-eudesmanolides, 1-O-acetylbritannilactone (3), 1,6-O,O-Diacetylbritannilactone (4), and 6α-O-(2- methylbutyryl)britannilactone (5) were isolated from the flower heads of the medicinal plant Inula britannica. Their structures were characterized by spectroscopic methods. X-ray data of 2 is reported for the first time.
    CONCLUSIONS:
    Among them, eudesmanolides 1 and 2 exhibited remarkable cytotoxicity against HEp2, SGC-7901 and HCT116 human cancer cell lines, comparable with etoposide (Vp-16) used as reference drug. Furthermore, treatment of HEp2 cells with 1 induced apoptosis associated with cleaved procaspase-3 and PARP. The biological assays carried out with normal cells (CHO) revealed that all sesquiterpenes were weakly selective against the cancer cell lines tested.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.8539 mL 14.2694 mL 28.5388 mL 57.0776 mL 71.347 mL
    5 mM 0.5708 mL 2.8539 mL 5.7078 mL 11.4155 mL 14.2694 mL
    10 mM 0.2854 mL 1.4269 mL 2.8539 mL 5.7078 mL 7.1347 mL
    50 mM 0.0571 mL 0.2854 mL 0.5708 mL 1.1416 mL 1.4269 mL
    100 mM 0.0285 mL 0.1427 mL 0.2854 mL 0.5708 mL 0.7135 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    天名精内酯酮; Carabrone CFN99825 1748-81-8 C15H20O3 = 248.3 5mg QQ客服:215959384
    二氢莪术双环烯酮; Dihydrocurcumenone CFN92649 142717-57-5 C15H24O2 = 236.4 5mg QQ客服:1413575084
    莪术双环烯酮; Curcumenone CFN92026 100347-96-4 C15H22O2 = 234.3 5mg QQ客服:2056216494
    Curcumadionol; Curcumadionol CFN92653 1235984-45-8 C15H20O3 = 248.3 5mg QQ客服:1457312923
    (1R-顺式)-5-甲基-alpha-亚甲基-4-(3-氧代丁基)-3-环庚烯-1-乙酸; 4-Oxobedfordiaic acid CFN97170 68799-38-2 C15H22O3 = 250.3 5mg QQ客服:2159513211
    3-Hydroxy-4,15-dinor-1(5)-xanthen-12,8-olide; 3-Hydroxy-4,15-dinor-1(5)-xanthen-12,8-olide CFN99095 1093207-99-8 C13H20O3 = 224.3 5mg QQ客服:215959384
    叶黄制菌素; Xanthatin CFN98315 26791-73-1 C15H18O3 = 246.3 5mg QQ客服:1457312923
    8-Epixanthatin; 8-Epixanthatin CFN89507 30890-35-8 C15H18O3 = 246.30 5mg QQ客服:1457312923
    6alpha-Hydroxytomentosin; 6alpha-Hydroxytomentosin CFN89001 1232676-22-0 C15H20O4 = 264.32 5mg QQ客服:215959384
    黄质宁; Xanthinin CFN99644 153483-31-9 C17H22O5 = 306.4 5mg QQ客服:2056216494

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