1,6-O,O-二乙酰大花旋覆花内酯

1,6-O,O-Diacetylbritannilactone

	产品编号	CFN89518
	CAS编号	1286694-67-4
	分子式 = 分子量	C₁₉H₂₆O₆ = 350.40
	产品纯度	>=98%
	物理属性	Cryst.
	化合物类型	Sesquiterpenoids
	植物来源	The flower heads of Inula britannica.
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
1,6-O,O-二乙酰大花旋覆花内酯	CFN89518	1286694-67-4	1mg	QQ客服：2056216494
1,6-O,O-二乙酰大花旋覆花内酯	CFN89518	1286694-67-4	5mg	QQ客服：2056216494
1,6-O,O-二乙酰大花旋覆花内酯	CFN89518	1286694-67-4	10mg	QQ客服：2056216494
1,6-O,O-二乙酰大花旋覆花内酯	CFN89518	1286694-67-4	20mg	QQ客服：2056216494

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Description:

1,6-O,O-Diacetylbritannilactone(OODBL) has anti-inflammatory activity, it has a potential therapeutic efficacy on inflammatory diseases especially allergic airway disease as a lead compound. OODBL has anti-asthmatic activity, it reduces leukotriene C4 production and degranulation through the suppression of cytosolic phospholipase A2 phosphorylation and phospholipase Cγ-mediated Ca2+ influx in IgE/antigen-stimulated BMMCs. OODBL also exhibits potent antitumor activity against several human cancer cell lines.

Targets:

In vitro:

Inflammation. 2017 Dec;40(6):1967-1974

1,6-O,O-Diacetylbritannilactone Inhibits Eotaxin-1 and ALOX15 Expression Through Inactivation of STAT6 in A549 Cells.[Pubmed: 28770377]

1,6-O,O-Diacetylbritannilactone (OODBL), a plant sesquiterpene lactone, was previously reported to show multiple pharmacological effects such as anti-cancer and anti-inflammatory activities.
METHODS AND RESULTS:
In this study, we investigated the anti-inflammatory effect of OODBL on interleukin (IL)-4-induced signal transducer and activator of transcription 6 (STAT6) signaling pathway in human lung A549 cells. We found that OODBL dramatically inhibited IL-4-induced messenger RNA (mRNA) expression of eotaxin-1 and arachidonate 15-lipoxygenase-1 (ALOX15) in a dose-dependent manner. To clarify the action mechanism of OODBL, we examined the effect of OODBL on activation of STAT6. OODBL decreased both STAT6 phosphorylation and reporter gene activity. Furthermore, OODBL suppressed phosphorylation of Janus Kinase 3 (JAK3) without affecting JAK1.
CONCLUSIONS:
Taken together, OODBL abolished IL-4-induced eotaxin-1 and ALOX15 mRNA expressions by repressing the activation of STAT6 and JAK3. These results suggest that OODBL has a potential therapeutic efficacy on inflammatory diseases especially allergic airway disease as a lead compound.

Nat Prod Commun. 2016 Jan;11(1):7-10.

Cytotoxic and Pro-apoptotic Activities of Sesquiterpene Lactones from Inula britannica.[Pubmed: 26996005]

METHODS AND RESULTS:
In this study, five known sesquiterpene lactones (STL) with an α-methylene-γ-lactone motif, including two eudesmanolides, 1β-hydroxyalantolactone (1) and ivangustin (2), and three 1,10-seco-eudesmanolides, 1-O-acetylbritannilactone (3), 1,6-O,O-Diacetylbritannilactone (4), and 6α-O-(2- methylbutyryl)britannilactone (5) were isolated from the flower heads of the medicinal plant Inula britannica. Their structures were characterized by spectroscopic methods. X-ray data of 2 is reported for the first time.
CONCLUSIONS:
Among them, eudesmanolides 1 and 2 exhibited remarkable cytotoxicity against HEp2, SGC-7901 and HCT116 human cancer cell lines, comparable with etoposide (Vp-16) used as reference drug. Furthermore, treatment of HEp2 cells with 1 induced apoptosis associated with cleaved procaspase-3 and PARP. The biological assays carried out with normal cells (CHO) revealed that all sesquiterpenes were weakly selective against the cancer cell lines tested.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
1-O-乙酰旋覆花内酯; 1-O-Acetyl britannilactone	CFN90219	681457-46-5	C₁₇H₂₄O₅ = 266.34	20mg	QQ客服：2056216494
1,6-O,O-二乙酰大花旋覆花内酯; 1,6-O,O-Diacetylbritannilactone	CFN89518	1286694-67-4	C₁₉H₂₆O₆ = 350.40	5mg	QQ客服：3257982914
1-O-乙酰-6β-O-异丁酰旋覆花内酯; 1-O-Acetyl-6beta-O-Isobutyrylbritannilactone	CFN92598	1087072-50-1	C₂₁H₃₀O₆ = 378.5	5mg	QQ客服：1457312923
1-O-乙酰基-6alpha-O-(2-甲基丁酰)大花旋覆花内酯; 1-O-Acetyl-6alpha-O-(2-methylbutyryl)britannilactone	CFN89470	1932687-71-2	C₂₂H₃₂O₆ = 392.48	5mg	QQ客服：2056216494
二大花旋覆花内酯 B; Dibritannilactone B	CFN89501	1829580-18-8	C₃₄H₄₆O₉ = 598.72	5mg	QQ客服：2056216494
天名精内酯酮; Carabrone	CFN99825	1748-81-8	C₁₅H₂₀O₃ = 248.3	5mg	QQ客服：1457312923
二氢莪术双环烯酮; Dihydrocurcumenone	CFN92649	142717-57-5	C₁₅H₂₄O₂ = 236.4	5mg	QQ客服：1413575084
莪术双环烯酮; Curcumenone	CFN92026	100347-96-4	C₁₅H₂₂O₂ = 234.3	5mg	QQ客服：2159513211
Curcumadionol; Curcumadionol	CFN92653	1235984-45-8	C₁₅H₂₀O₃ = 248.3	5mg	QQ客服：215959384
(1R-顺式)-5-甲基-alpha-亚甲基-4-(3-氧代丁基)-3-环庚烯-1-乙酸; 4-Oxobedfordiaic acid	CFN97170	68799-38-2	C₁₅H₂₂O₃ = 250.3	5mg	QQ客服：2056216494

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.8539 mL	14.2694 mL	28.5388 mL	57.0776 mL	71.347 mL
5 mM	0.5708 mL	2.8539 mL	5.7078 mL	11.4155 mL	14.2694 mL
10 mM	0.2854 mL	1.4269 mL	2.8539 mL	5.7078 mL	7.1347 mL
50 mM	0.0571 mL	0.2854 mL	0.5708 mL	1.1416 mL	1.4269 mL
100 mM	0.0285 mL	0.1427 mL	0.2854 mL	0.5708 mL	0.7135 mL

1,6-O,O-二乙酰大花旋覆花内酯

1,6-O,O-Diacetylbritannilactone

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