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  • 1-beta-羟基蔷薇酸

    1beta-Hydroxyeuscaphic acid

    1-beta-羟基蔷薇酸
    产品编号 CFN92609
    CAS编号 120211-98-5
    分子式 = 分子量 C30H48O6 = 504.7
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Triterpenoids
    植物来源 The herbs of Agrimonia pilosa
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    1-beta-羟基蔷薇酸 CFN92609 120211-98-5 1mg QQ客服:215959384
    1-beta-羟基蔷薇酸 CFN92609 120211-98-5 5mg QQ客服:215959384
    1-beta-羟基蔷薇酸 CFN92609 120211-98-5 10mg QQ客服:215959384
    1-beta-羟基蔷薇酸 CFN92609 120211-98-5 20mg QQ客服:215959384
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Universit?t Basel (Switzerland)
  • University of Medicine and Pharmacy (Romania)
  • Massachusetts General Hospital (USA)
  • Molecular Biology Institute of Barcelona (IBMB)-CSIC (Spain)
  • University of Wuerzburg (Germany)
  • Universiti Malaysia Pahang (Malaysia)
  • University of Dicle (Turkey)
  • Mendel University in Brno (Czech Republic)
  • Julius Kühn-Institut (Germany)
  • Korea Institute of Oriental Medicine (Korea)
  • Martin Luther University of Halle-Wittenberg (Germany)
  • Ain Shams University (Egypt)
  • Heinrich-Heine-University Düsseldorf (Germany)
  • Imperial College London (United Kingdom)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • PLoS One.2018, 13(11):e0208055
  • Saf Health Work.2019, 10(2):196-204
  • Front Microbiol.2022, 13:835463.
  • Plants (Basel).2021, 10(5):951.
  • Toxicol In Vitro.2022, 81:105346.
  • Biomed Pharmacother.2019, 111:262-269
  • Molecules.2019, 24(21):E3834
  • Ind Crops Prod.2014, 62:173-178
  • Nutrients.2018, 10(12):E1998
  • J Food Sci.2022, 87(11):4905-4916.
  • The Journal of Animal & Plant Sciences.2020, 30(6):1366-1373
  • J Food Compos Anal2017, 62:197-204
  • Biochem Systematics and Ecology2017, 11-18
  • Appl. Sci. 2021, 11(10),4666.
  • Cell Prolif.2021, 54(8):e13083.
  • Applied Biological Chemistry2023, 66:42.
  • Biomed Pharmacother.2022, 145:112410.
  • Life Sci.2019, 216:259-270
  • Int J Mol Sci.2023, 24(8):7442.
  • Toxicol Mech Methods.2021, 1-12.
  • Int J Biol Macromol.2021, 199:189-200.
  • Molecules.2020, 25(21):5091.
  • Molecules.2019, 24(7):E1290
  • ...
  • 生物活性
    Description: 1beta-Hydroxyeuscaphic acid has significant hepatoprotective activity by lowering the leakage of intracellular enzymes, reducing the oxidation of proteins and decreasing the incidence of apoptosis.
    Targets: SOD
    In vitro:
    Pharm Biol. 2013 Jun;51(6):686-90.
    Hepatoprotection of 1β-hydroxyeuscaphic acid - the major constituent from Rubus aleaefolius against CCl4-induced injury in hepatocytes cells.[Pubmed: 23527895]
    The protective effects of a major constituent, 1beta-Hydroxyeuscaphic acid isolated from R. aleaefolius was first investigated against carbon tetrachloride (CCl4)-induced injury in liver cells from hepatocytes cell line (BRL-3A).
    METHODS AND RESULTS:
    Following treatment with 1beta-Hydroxyeuscaphic acid at doses ranging from 1 to 100 µg/mL for 24 h, cellular morphology, cell growth function (MTT assay), ALT, AST, malondialdehyde (MDA) and superoxide dismutase (SOD) were assessed and evaluated under control and exposed conditions. The IC50 of 1beta-Hydroxyeuscaphic acid was 15 μg/mL. Exposure of injured BRL-3A at 20 μg/mL changed abnormal size, cellular shrinkage, and enhanced regulation. ALT, AST, MDA enzyme levels were reduced and SOD activity was increased.
    CONCLUSIONS:
    Treatment with 1beta-Hydroxyeuscaphic acid has significant hepatoprotective activity by lowering the leakage of intracellular enzymes, reducing the oxidation of proteins and decreasing the incidence of apoptosis. These results provide a basis for confirming the traditional uses of R. aleaefolius in treating hepatic diseases.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.9814 mL 9.9069 mL 19.8138 mL 39.6275 mL 49.5344 mL
    5 mM 0.3963 mL 1.9814 mL 3.9628 mL 7.9255 mL 9.9069 mL
    10 mM 0.1981 mL 0.9907 mL 1.9814 mL 3.9628 mL 4.9534 mL
    50 mM 0.0396 mL 0.1981 mL 0.3963 mL 0.7926 mL 0.9907 mL
    100 mM 0.0198 mL 0.0991 mL 0.1981 mL 0.3963 mL 0.4953 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    2-氧代果树酸; 2-氧代坡模醇酸; 2-Oxopomolic acid CFN98920 54963-52-9 C30H46O5 = 486.7 5mg QQ客服:2159513211
    2alpha,19alpha-Dihydroxy-3-oxo-urs-12-en-28-oic acid; 2alpha,19alpha-Dihydroxy-3-oxo-urs-12-en-28-oic acid CFN89112 176983-21-4 C30H46O5 = 486.69 5mg QQ客服:215959384
    覆盆子酸; Fupenzic acid CFN99311 119725-20-1 C30H44O5 = 484.7 5mg QQ客服:215959384
    Negundonorin A; Negundonorin A CFN96848 1401618-51-6 C29H40O5 = 468.63 5mg QQ客服:1457312923
    1-beta-羟基蔷薇酸; 1beta-Hydroxyeuscaphic acid CFN92609 120211-98-5 C30H48O6 = 504.7 5mg QQ客服:1413575084
    1,2,3,19-四羟基-12-乌苏烯-28-酸; 1,2,3,19-Tetrahydroxy-12-ursen-28-oic acid CFN99233 113558-03-5 C30H48O6 = 504.7 5mg QQ客服:215959384
    1-羟基-2-氧代果树酸; 1-Hydroxy-2-oxopomolic acid CFN98080 217466-37-0 C30H46O6 = 502.7 5mg QQ客服:2056216494
    3-O-顺式对香豆酰委陵菜酸; 3-O-cis-p-Coumaroyltormentic acid CFN92211 121072-40-0 C39H54O7 = 634.9 5mg QQ客服:1457312923
    蔷薇酸; 野鸦椿酸; Euscaphic acid CFN98888 53155-25-2 C30H48O5 = 488.7 5mg QQ客服:1457312923
    2,3-Di-O-methylthiomethyleuscaphic acid; 2,3-Di-O-methylthiomethyleuscaphic acid CFN97578 N/A C34H56O5S2 = 609.0 5mg QQ客服:2056216494

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