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  • 2alpha,19alpha-Dihydroxy-3-oxo-urs-12-en-28-oic acid

    • 2alpha,19alpha-Dihydroxy-3-oxo-urs-12-en-28-oic acid

    2alpha,19alpha-Dihydroxy-3-oxo-urs-12-en-28-oic acid

    2alpha,19alpha-Dihydroxy-3-oxo-urs-12-en-28-oic acid
    		产品编号 CFN89112
    CAS编号 176983-21-4
    分子式 = 分子量 C30H46O5 = 486.69
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Triterpenoids
    植物来源 The leaves of Eriobotrya japonica.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    2alpha,19alpha-Dihydroxy-3-oxo-urs-12-en-28-oic acid CFN89112 176983-21-4 1mg QQ客服：1457312923
    2alpha,19alpha-Dihydroxy-3-oxo-urs-12-en-28-oic acid CFN89112 176983-21-4 5mg QQ客服：1457312923
    2alpha,19alpha-Dihydroxy-3-oxo-urs-12-en-28-oic acid CFN89112 176983-21-4 10mg QQ客服：1457312923
    2alpha,19alpha-Dihydroxy-3-oxo-urs-12-en-28-oic acid CFN89112 176983-21-4 20mg QQ客服：1457312923
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
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    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
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  • Biomolecules.2024, 14(5):589.
  • Food Chem.2022, 378:131975.
  • Plants.2024, 13(10):1348;
  • The Korea Society of Pha.2014, 300-314
  • Biomolecules.2021, 11(10):1537.
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  • Appl. Sci. 2021, 11(22),10569
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  • Oxid Med Cell Longev2019, 9056845:13
  • Biomed Chromatogr.2020, e5021.
  • Eur J Pharmacol.2020, 889:173589.
  • Nutrients.2021, 13(10):3414.
  • Front Nutr.2021, 8: 687851.
  • Journal of Applied Pharmaceutical Science2022, 0(00), pp:001-007
  • Viruses.2021, 13(11):2118.
  • Int J Mol Sci.2020, 21(6):2190.
  • Foods.2020, 9(10):1348.
  • Antioxidants (Basel).2019, 8(8):E307
  • ...
    • 生物活性
    Description: 2alpha,19alpha-Dihydroxy-3-oxo-urs-12-en-28-oic acid has anti-HIV activity. It shows an inhibitory effect on the activation of Epstein-Barr virus early antigen (EBV-EA) induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) and causes a significant delay of two-stage carcinogenesis on mouse skin.
    Targets: HIV
    In vitro:
    Phytochemistry. 2002 Feb;59(3):315-23.
    Production of bioactive triterpenes by Eriobotrya japonica calli.[Pubmed: 11830140]

    METHODS AND RESULTS:
    Callus tissue cultures induced from an axenic leaf of Eriobotrya japonica (Rosaceae) produced triterpenes in large amounts (ca. 50 mg/g dry wt). Nine triterpenes were characterized as ursolic acid, oleanolic acid, 2alpha-hydoxyursolic acid, maslinic acid, tormentic acid, 2alpha,19alpha-Dihydroxy-3-oxo-urs-12-en-28-oic acid, hyptadienic acid and a mixture of 3-O-cis-p-coumaroyltormentic acid and 3-O-trans-p-coumaroyltormentic acid. The triterpene composition in the callus tissues was noticeably different from that in intact leaves. The contents of tormentic acid with antidiabetic action, and 2alpha,19alpha-Dihydroxy-3-oxo-urs-12-en-28-oic acid with anti-HIV activity, were much larger than those in the intact leaves.
    CONCLUSIONS:
    All of the triterpenes isolated from the callus tissues showed an inhibitory effect comparable to (-)-epigallocatechin gallate (EGCG) of green tea on the activation of Epstein-Barr virus early antigen (EBV-EA) induced by 12-O-tetradecanoylphorbol-13-acetate (TPA). 2alpha,19alpha-Dihydroxy-3-oxo-urs-12-en-28-oic acid was the most potent inhibitor among them and caused a significant delay of two-stage carcinogenesis on mouse skin.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.0547 mL 10.2735 mL 20.547 mL 41.0939 mL 51.3674 mL
    5 mM 0.4109 mL 2.0547 mL 4.1094 mL 8.2188 mL 10.2735 mL
    10 mM 0.2055 mL 1.0273 mL 2.0547 mL 4.1094 mL 5.1367 mL
    50 mM 0.0411 mL 0.2055 mL 0.4109 mL 0.8219 mL 1.0273 mL
    100 mM 0.0205 mL 0.1027 mL 0.2055 mL 0.4109 mL 0.5137 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    Negundonorin A; Negundonorin A CFN96848 1401618-51-6 C29H40O5 = 468.63 5mg QQ客服：1457312923
    1-beta-羟基蔷薇酸; 1beta-Hydroxyeuscaphic acid CFN92609 120211-98-5 C30H48O6 = 504.7 5mg QQ客服：1457312923
    1,2,3,19-四羟基-12-乌苏烯-28-酸; 1,2,3,19-Tetrahydroxy-12-ursen-28-oic acid CFN99233 113558-03-5 C30H48O6 = 504.7 5mg QQ客服：2159513211
    1-羟基-2-氧代果树酸; 1-Hydroxy-2-oxopomolic acid CFN98080 217466-37-0 C30H46O6 = 502.7 5mg QQ客服：2159513211
    3-O-顺式对香豆酰委陵菜酸; 3-O-cis-p-Coumaroyltormentic acid CFN92211 121072-40-0 C39H54O7 = 634.9 5mg QQ客服：215959384
    蔷薇酸； 野鸦椿酸; Euscaphic acid CFN98888 53155-25-2 C30H48O5 = 488.7 5mg QQ客服：1457312923
    2,3-Di-O-methylthiomethyleuscaphic acid; 2,3-Di-O-methylthiomethyleuscaphic acid CFN97578 N/A C34H56O5S2 = 609.0 5mg QQ客服：215959384
    2,3-O-异亚丙基刺梨酸; 2,3-O-Isopropylidenyl euscaphic acid CFN98095 220880-90-0 C33H52O5 = 528.8 5mg QQ客服：2056216494
    2-表委陵菜酸; 2-Epitormentic acid CFN99310 119725-19-8 C30H48O5 = 488.7 5mg QQ客服：215959384
    2-氧代果树酸; 2-氧代坡模醇酸; 2-Oxopomolic acid CFN98920 54963-52-9 C30H46O5 = 486.7 5mg QQ客服：2159513211

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