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  • alpha-菠菜甾醇

    alpha-Spinasterol

    alpha-菠菜甾醇
    产品编号 CFN98748
    CAS编号 481-18-5
    分子式 = 分子量 C29H48O = 412.7
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Steroids
    植物来源 The roots of Bupleurum chinense DC.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
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    alpha-菠菜甾醇 CFN98748 481-18-5 1mg QQ客服:1413575084
    alpha-菠菜甾醇 CFN98748 481-18-5 5mg QQ客服:1413575084
    alpha-菠菜甾醇 CFN98748 481-18-5 10mg QQ客服:1413575084
    alpha-菠菜甾醇 CFN98748 481-18-5 20mg QQ客服:1413575084
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Medizinische Universit?t Wien (Austria)
  • University of Queensland (Australia)
  • University of Virginia (USA)
  • Universidade do Porto (Portugal)
  • University of Mysore (India)
  • University of Wollongong (Australia)
  • Copenhagen University (Denmark)
  • Universiti Malaysia Pahang (Malaysia)
  • Nicolaus Copernicus Uniwersity (Poland)
  • Donald Danforth Plant Science Center (USA)
  • University of Illinois (USA)
  • Tohoku University (Japan)
  • Institute of Bioorganic Chemistry Polish Academy of Sciences (Poland)
  • Washington State University (USA)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Mol Med Rep.2015, 12(5):7789-95
  • Food Analytical Methods2017, 10:3225–3234
  • Pharmacognosy Magazine2017, 13(52):868-874
  • Research on Crops.2017, 18(3):569
  • Cell Physiol Biochem.2017, 43(4):1425-1435
  • Phytochemistry Letters2017, 449-455
  • Aquaculture2017, 481:94-102
  • Food Res Int.2017, 96:40-45
  • BMC Plant Biol.2018, 18(1):122
  • BMC Pharmacol Toxicol.2018, 19(1):5
  • Bioorg Med Chem.2018, 26(14):4201-4208
  • Asian Journal of Chemistry2018, 30(12):2699-2703
  • Industrial Crops and Products2018, 353-362
  • The Journal of Agromedicine and Medical Sciences2018, 4(1)
  • Toxicol In Vitro.2018, 52:94-105
  • Bio-protocol2018, 9(14):e3301
  • Analytical methods2019, 11(6)
  • Chinese Medicine2019, 14(1)
  • Nutr Metab (Lond).2019, 16:31
  • J Pharm Biomed Anal.2019, 164:119-127
  • Int J Mol Sci.2019, 20(23):E6071
  • Ann Transl Med.2019, 7(23):731
  • J Sep Sci.2020, 201901140
  • ...
  • 生物活性
    Description: Alpha-Spinasterol is a novel efficacious and safe antagonist of the TRPV1 receptor with anti-inflammatory and antinociceptive effects.Alpha-Spinasterol has a significant therapeutic potential to modulate the development and/or progression of diabetic nephropathy. It also can prevent TP-induced prostatic hyperplasia and may be beneficial in the management of benign prostatic hyperplasia.
    Targets: TRPV | HMG-CoA reductase
    In vivo:
    Mol Med Rep. 2014 Jun;9(6):2362-6.
    α-Spinasterol from Melandrium firmum attenuates benign prostatic hyperplasia in a rat model.[Pubmed: 24682042]
    Spinasterol, a biologically active compound, exhibits a number of pharmacological activities, including antitumor, antiulcerogenic and anticarcinogenic activity, and originates from the aerial parts of Aster scaber Thunb (Asteraceae). The present study investigated whether alpha-Spinasterol isolated from Melandrium firmum Rohrbach could prevent benign prostatic hyperplasia (BPH) induced by testosterone propionate (TP) in rats.
    METHODS AND RESULTS:
    Male Wistar rats were randomly divided into four groups of eight rats following castration. A negative control group received subcutaneous injections of corn oil. Treatments were administered orally 1 h prior to TP injection. All the rats were sacrificed at the scheduled termination time and their prostates were removed, cleaned and weighed. The prostate size ratio (prostate weight/rat body weight) was then calculated. Additional histopathological examinations were conducted, and the levels of TP and dihydrotestosterone (DHT) in the serum and prostate were measured. TP significantly increased the prostate size ratio (P<0.01), and DHT and testosterone levels in the serum and prostate. The TP-induced increase was significantly inhibited in alpha-Spinasterol-treated rats when compared with the negative controls (P<0.05). In addition, histopathological examination demonstrated that α-spinasterol treatment suppressed TP-induced prostatic hyperplasia.
    CONCLUSIONS:
    It is concluded that alpha-Spinasterol can prevent TP-induced prostatic hyperplasia and may be beneficial in the management of BPH.
    J Ethnopharmacol. 2014;151(1):144-50.
    Anti-inflammatory action of hydroalcoholic extract, dichloromethane fraction and steroid α-spinasterol from Polygala sabulosa in LPS-induced peritonitis in mice.[Pubmed: 24161429]
    Polygala sabulosa A. W. Bennett is a small herb popularly known as "timutu-pinheirinho" that is widely distributed in southern Brazil and that is used to treat disorders of the bowel and kidney and as a topical anesthetic and expectorant in folk medicine. This study was designed to investigate the anti-inflammatory properties of the hydroalcoholic extract (HEPs), CH2Cl2 fraction and the steroid α-spinasterol obtained from the aerial parts of Polygala sabulosa in a model of acute inflammation induced by intraperitoneal injection of bacterial lipopolysaccharide in mice.
    METHODS AND RESULTS:
    The anti-inflammatory effect of HEPs (3-300 mg/kg, i.g.), CH2Cl2 fraction (0.003-30 mg/kg, i.g.) and steroid α-spinasterol (0.001-1mg/kg, i.p. or 1-10mg/kg, i.g.), were evaluated in mice subjected to the acute inflammation caused by intraperitoneal (i.p.) injection of lipopolysaccharide (LPS, 0.02 µg/kg). The anti-inflammatory activity of the HEPs, CH2Cl2 fraction and steroid were assessed by determining the total numbers of leukocytes and differential cell counts (neutrophils and mononuclear cells) and levels of pro-inflammatory (IL-1β, TNF-α, IL-6) or anti-inflammatory (IL-10) cytokines in peritoneal fluid. The administration of HEPs (3-300 mg/kg, i.g.) completely inhibited inflammatory cell infiltration (300 mg/kg, i.g.) and it reduced TNF-α (100-300 mg/kg) and IL-1β (100mg/kg) levels in LPS-injected mice. Furthermore, the administration of CH2Cl2 fraction (0.003-30 mg/kg, i.g.) or α-spinasterol (0.001-10mg/kg, by i.p. or i.g.) significantly reduces inflammatory cell infiltration in LPS-injected mice. Moreover, dexamethasone (0.5mg/kg, i.p., used as a positive control) inhibited inflammatory cell infiltration and reduced the levels of TNF-α, IL-1β and IL-6 in LPS-injected mice.
    CONCLUSIONS:
    Taken together, these results provide the first experimental evidence demonstrating that HEPs have significant anti-inflammatory effects on LPS-induced inflammation. These effects appear to be, at least in part, due to the presence of α-spinasterol. These findings support the widespread use of Polygala sabulosa in popular medicine and demonstrate that this plant has therapeutic potential for the development of phytomedicines with anti-inflammatory properties.
    Planta Med. 2004 Aug;70(8):736-9.
    alpha-Spinasterol isolated from the root of Phytolacca americana and its pharmacological property on diabetic nephropathy.[Pubmed: 15326549 ]

    METHODS AND RESULTS:
    Based on an inhibitory activity-guided fractionation for the high glucose-induced proliferation of glomerular mesangial cells (GMCs), chloroform extracts of the roots of Phytolacca americana were found to contain alpha-Spinasterol (C (29)H (48)O), a delta (7)-sterol. This phytosterol proved to be a potent inhibitor (IC (50) = 3.9 x 10 (-12) g/mL, 9.5 pmol/L) of glomerular mesangial cell proliferation caused by high-ambient glucose (5.6 mM vs. 25 mM), and its inhibitory potency was about 1,000 times higher than that of simvastatin, an HMG-CoA reductase inhibitor used as a positive control. alpha-Spinasterol also significantly reduced the increases of serum triglycerides, renal weight and urinary protein excretion in streptozotocin-induced diabetic mice, and these were comparable to the results observed in insulin-treated diabetic mice.
    CONCLUSIONS:
    Therefore, the results obtained in this study suggest that alpha-Spinasterol has a significant therapeutic potential to modulate the development and/or progression of diabetic nephropathy.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.4231 mL 12.1153 mL 24.2307 mL 48.4614 mL 60.5767 mL
    5 mM 0.4846 mL 2.4231 mL 4.8461 mL 9.6923 mL 12.1153 mL
    10 mM 0.2423 mL 1.2115 mL 2.4231 mL 4.8461 mL 6.0577 mL
    50 mM 0.0485 mL 0.2423 mL 0.4846 mL 0.9692 mL 1.2115 mL
    100 mM 0.0242 mL 0.1212 mL 0.2423 mL 0.4846 mL 0.6058 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    alpha-菠菜甾醇; alpha-Spinasterol CFN98748 481-18-5 C29H48O = 412.7 10 mg QQ客服:2159513211
    alpha-菠菜甾醇乙酸酯; alpha-Spinasterol acetate CFN98692 4651-46-1 C31H50O2 = 454.7 5mg QQ客服:2159513211
    alpha-波菜甾酮; alpha-Spinasterone CFN98243 23455-44-9 C29H46O = 410.7 5mg QQ客服:215959384
    豆甾-4-烯-3-酮; Sitostenone CFN99073 1058-61-3 C29H48O = 412.7 5mg QQ客服:1413575084
    豆甾-4,22,25-三烯-3-酮; Stigmasta-4,22,25-trien-3-one CFN97408 848669-09-0 C29H44O = 408.7 5mg QQ客服:1148253675
    豆甾-4,22-二烯-3-酮; Stigmasta-4,22-dien-3-one CFN98934 55722-32-2 C29H46O = 410.7 5mg QQ客服:1413575084
    豆甾醇; Stigmasterol CFN97326 83-48-7 C29H48O = 412.7 20mg QQ客服:2159513211
    β-谷甾醇; Beta-Sitosterol CFN99916 83-46-5 C29H50O = 414.69 20mg QQ客服:2159513211
    β-谷甾基十六烷酸酯,棕榈酸谷甾醇酯; Sitosteryl palmitate CFN98235 2308-85-2 C45H80O2 = 653.1 5mg QQ客服:2159513211
    豆甾-5,8-二烯-3-醇; Stigmasta-5,8-dien-3-ol CFN98959 570-72-9 C29H48O = 412.7 5mg QQ客服:215959384

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