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    产品编号 CFN99916
    CAS编号 83-46-5
    分子式 = 分子量 C29H50O = 414.69
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Steroids
    植物来源 The herbs of Anemone cathayensis Kitag.
    产品名称 产品编号 CAS编号 包装 QQ客服
    β-谷甾醇 CFN99916 83-46-5 10mg QQ客服:1148253675
    β-谷甾醇 CFN99916 83-46-5 20mg QQ客服:1148253675
    β-谷甾醇 CFN99916 83-46-5 50mg QQ客服:1148253675
    β-谷甾醇 CFN99916 83-46-5 100mg QQ客服:1148253675
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    Cell. 2018 Jan 11;172(1-2):249-261.e12.
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    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
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    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.

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    doi: 10.1126/sciadv.aat6994.

    PMID: 30417089
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  • University of Wuerzburg (Germany)
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  • Uniwersytet Medyczny w ?odzi (Poland)
  • Chang Gung University (Taiwan)
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  • Ain Shams University (Egypt)
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  • ...
  • 生物活性
    Description: Beta-Sitosterol is a novel plant-derived angiogenic factor which may have potential pharmaceutical applications for the management of chronic wounds. It has potent anti-inflammatory, anti-proliferation, and pro- apoptosis activities, it also possesses antipyretic activity, similar to acetylsalicylic acid.
    Targets: PARP | Bcl-2/Bax | Caspase | IAP
    In vitro:
    Biol Pharm Bull. 2007 Jul;30(7):1317-23.
    Beta-sitosterol induces anti-proliferation and apoptosis in human leukemic U937 cells through activation of caspase-3 and induction of Bax/Bcl-2 ratio.[Pubmed: 17603173]
    Beta-Sitosterol is the main dietary phytosterol found in plants and has been shown to inhibit proliferation and induce apoptosis in human solid tumors such as colon and breast cancers. However, the mechanism by which Beta-Sitosterol induces apoptosis is not completely understood in leukemic cells.
    This study investigated the mechanism of apoptosis induced by Beta-Sitosterol in human leukemic U937 cells. Beta-Sitosterol induced cytotoxicity and apoptosis in U937 cells in a concentration dependent manner, as measured by hemocytometer counts, fluorescence microscopy, agarose gel electrophoresis, and flow cytometry analysis. The increase in apoptosis induced by Beta-Sitosterol was associated with down-regulation of Bcl-2, degradation of poly-(ADP-ribose) polymerase (PARP) and phospholipase C (PLC)-gamma1 protein, and activation of caspase-3. Beta-Sitosterol induced apoptosis was not associated with changes in the expression of Bcl-xL, Bax, or inhibitor of apoptosis proteins (IAPs). z-DEVD-fmk, a caspase-3 specific inhibitor, blocked caspase-3 activation and PARP degradation, and significantly attenuated Beta-Sitosterol-induced apoptosis. This suggests that caspase-3 activation is partially essential for Beta-Sitosterol-induced apoptosis. Bcl-2 overexpression also significantly blocked caspase-3 activation and the decrease in PARP cleavage by Beta-Sitosterol, and effectively attenuated the apoptotic response to Beta-Sitosterol.
    These results show that Beta-Sitosterol potently induces apoptosis in U937 cells and that Beta-Sitosterol-induced apoptosis is related to the selective activation of caspase-3 and induction of Bax/Bcl-2 ratio.
    Angiogenesis. 1999;3(2):117-23.
    A novel angiogenic factor derived from Aloe vera gel: beta-sitosterol, a plant sterol.[Pubmed: 14517429]
    Aloe vera gel has a beneficial effect on wound healing. Because angiogenesis is an essential process in wound healing, we hypothesized that Aloe vera gel might contain potent angiogenic compounds.
    Here we demonstrate that Aloe vera gel and its extracts are angiogenic on the chorioallantoic membrane (CAM) of chick embryo. Out of the three compounds purified from the final fraction of Aloe vera gel, beta-sitosterol showed a potent angiogenic activity in the CAM assay. In the presence of heparin, beta-sitosterol stimulated neovascularization in the mouse Matrigel plug assay and the motility of human umbilical vein endothelial cells in an in vitro wound migration assay.
    Thus beta-sitosterol is a novel plant-derived angiogenic factor which may have potential pharmaceutical applications for the management of chronic wounds.
    In vivo:
    Planta Med. 1980 Jun;39(2):157-63.
    Anti-inflammatory and antipyretic activities of beta-sitosterol[Reference: WebLink]

    The anti-inflammatory and antipyretic activities of Beta-Sitosterol , isolated from the plant CYPERUS ROTUNDUS has been studied, employing carrageenin induced oedema, cotton pellet implantation and Brewer's yeast induced pyrexia in rats. Beta-Sitosterol was found to possess potent anti-inflammatory activity against both the tests, similar to hydrocortisone and oxyphenbutazone when administered intraperitoneally. Moreover, it was also orally effective against carrageenin induced oedema. The antiinflammatory activity of Beta-Sitosterol was independent of pituitary adrenal axis. Beta-Sitosterol also possessed antipyretic activity, similar to acetylsalicylic acid. However, it was devoid of analgesic activity against aconitine induced writhing in mice. Beta-Sitosterol showed a wide margin of safety since the approximate LD 50 was more than 3 g/kg i.p. in mice and minimum ulcerogenic dose was 600 mg/kg i.p. in rats.
    The presence of the anti-inflammatory and antipyretic activities with wide margin of safety, Beta-Sitosterol may be of therapeutic value.
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.4114 mL 12.0572 mL 24.1144 mL 48.2288 mL 60.286 mL
    5 mM 0.4823 mL 2.4114 mL 4.8229 mL 9.6458 mL 12.0572 mL
    10 mM 0.2411 mL 1.2057 mL 2.4114 mL 4.8229 mL 6.0286 mL
    50 mM 0.0482 mL 0.2411 mL 0.4823 mL 0.9646 mL 1.2057 mL
    100 mM 0.0241 mL 0.1206 mL 0.2411 mL 0.4823 mL 0.6029 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    alpha-波菜甾酮; alpha-Spinasterone CFN98243 23455-44-9 C29H46O = 410.7 5mg QQ客服:1413575084
    豆甾-4-烯-3-酮; Sitostenone CFN99073 1058-61-3 C29H48O = 412.7 5mg QQ客服:215959384
    豆甾-4,22,25-三烯-3-酮; Stigmasta-4,22,25-trien-3-one CFN97408 848669-09-0 C29H44O = 408.7 5mg QQ客服:3257982914
    豆甾-4,22-二烯-3-酮; Stigmasta-4,22-dien-3-one CFN98934 55722-32-2 C29H46O = 410.7 5mg QQ客服:2159513211
    豆甾醇; Stigmasterol CFN97326 83-48-7 C29H48O = 412.7 20mg QQ客服:2932563308
    β-谷甾醇; Beta-Sitosterol CFN99916 83-46-5 C29H50O = 414.69 20mg QQ客服:2932563308
    β-谷甾基十六烷酸酯,棕榈酸谷甾醇酯; Sitosteryl palmitate CFN98235 2308-85-2 C45H80O2 = 653.1 5mg QQ客服:1148253675
    豆甾-5,8-二烯-3-醇; Stigmasta-5,8-dien-3-ol CFN98959 570-72-9 C29H48O = 412.7 5mg QQ客服:1148253675
    alpha-菠菜甾醇; alpha-Spinasterol CFN98748 481-18-5 C29H48O = 412.7 10 mg QQ客服:215959384
    alpha-菠菜甾醇乙酸酯; alpha-Spinasterol acetate CFN98692 4651-46-1 C31H50O2 = 454.7 5mg QQ客服:1148253675





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