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  • alpha-菠菜甾醇乙酸酯

    alpha-Spinasterol acetate

    alpha-菠菜甾醇乙酸酯
    产品编号 CFN98692
    CAS编号 4651-46-1
    分子式 = 分子量 C31H50O2 = 454.7
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Steroids
    植物来源 The herbs of Inula britannica L.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    alpha-菠菜甾醇乙酸酯 CFN98692 4651-46-1 1mg QQ客服:3257982914
    alpha-菠菜甾醇乙酸酯 CFN98692 4651-46-1 5mg QQ客服:3257982914
    alpha-菠菜甾醇乙酸酯 CFN98692 4651-46-1 10mg QQ客服:3257982914
    alpha-菠菜甾醇乙酸酯 CFN98692 4651-46-1 20mg QQ客服:3257982914
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of Wollongong (Australia)
  • Complutense University of Madrid (Spain)
  • University of Illinois at Chicago (USA)
  • Medizinische Universit?t Wien (Austria)
  • Kyung Hee University (Korea)
  • Anna University (India)
  • University of Padjajaran (Indonesia)
  • University of Canterbury (New Zealand)
  • Subang Jaya Medical Centre (Malaysia)
  • University of Zurich (Switzerland)
  • Gyeongsang National University (Korea)
  • University of Oslo (Norway)
  • Nanjing University of Chinese Medicine (China)
  • Mahatma Gandhi University (India)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Faculty of Chem. & Nat. Resource Eng.2014, 62
  • Phytochemistry Letters2015, 243-247
  • J Agric Food Chem.2015, 63(44):9869-78
  • Phytomedicine.2016, 23(4):331-9
  • Kor. J. Pharmacogn.2016, 47(1):62-72
  • PLoS One.2017, 12(3):e0173585
  • Research on Crops.2017, 18(2)
  • JPC-Journal of Planar Chromatography 2017, 30(2)
  • Front Plant Sci.2017, 8:723
  • J of Engineering Science&Technology2018, 13(9):2820-2828
  • Molecules.2018, 23(3):E615
  • J Liq Chromatogr R T2018, 41(12):761-769
  • Front Aging Neurosci.2019, 11:230
  • ACS Chem Biol.2019, 14(5):873-881
  • J of the Korean Society of Cosmetics and Cosmetology2019, 225-231
  • Molecules.2019, 24(2):329
  • Food Chem.2019, 274:345-350
  • Journal of Oil Palm Research2019, 31(2):238-247
  • Phytother Res.2019, 33(5):1490-1500
  • FASEB J.2019, 33(8):9685-9694
  • Phytomedicine.2019, 61:152813
  • J Pharmaceut Biomed2020, 182:113110
  • Cell Metab.2020, S1550-4131(20)30002-4
  • ...
  • 生物活性
    Description: alpha-Spinasterol has a significant therapeutic potential to modulate the development and/or progression of diabetic nephropathy.
    In vitro:
    Journal of Agricultural & Food Chemistry, 2013, 61(51):12692-12699.
    New triterpenoids and other constituents from the fruits of Benincasa hispida (Thunb.) Cogn.[Pubmed: 24313299 ]

    METHODS AND RESULTS:
    Benincasa hispida (Thunb.) Cogn. fruits are widely consumed in China and tropical countries. This study identifies three new triterpenoids, 3α,29-O-di-trans-cinnamoyl-D:C-friedooleana-7,9(11)-diene (1), oleanolic acid 28-O-β-d-xylopyranosyl-[β-d-xylopyranosyl-(1→4)]-(1→3)-α-l-rhamnopyranosyl-(1→2)-α-l-arabinopyranoside (2), and oleanolic acid 28-O-β-d-glucopyranosyl-(1→3)-β-d-xylopyranosyl-[β-d-xylopyranosyl-(1→4)]-(1→3)-α-l-rhamnopyranosyl-(1→2)-α-l-arabinopyranoside (3), together with 12 known compounds, multiflorenol (4), isomultiflorenyl acetate (5), stigmasterol (6), stigmasterol 3-O-β-d-glucopyranoside (7), α-spinasterol (alpha-Spinasterol acetate,8), α-spinasterol 3-O-β-d-glucopyranoside (9), β-sitosterol (10), daucosterol (11), arbutin (12), nicotinic acid (13), (+)-pinonesinol (14), and ethyl β-d-glucopyranoside (15). The structures of compounds 1-15 were determined by spectroscopic and chemical methods.
    CONCLUSIONS:
    All the compounds with the exception of 4, 5, and 9-11 were isolated from B. hispida for the first time. The anticomplement activities of compounds 1-15 were assessed by Mayer's modified method. Compounds 1-15 showed no significant cytotoxic activity against HeLa human cervical, HL-60 human hepatoma, and SMMC-7721 human hepatoma cell lines.
    In vivo:
    Planta Medica, 2004, 70(08):736-739.
    alpha-Spinasterol isolated from the root of Phytolacca americana and its pharmacological property on diabetic nephropathy.[Pubmed: 15326549 ]

    METHODS AND RESULTS:
    Based on an inhibitory activity-guided fractionation for the high glucose-induced proliferation of glomerular mesangial cells (GMCs), chloroform extracts of the roots of Phytolacca americana were found to contain alpha-spinasterol(alpha-Spinasterol acetate) (C (29)H (48)O), a delta (7)-sterol. This phytosterol proved to be a potent inhibitor (IC (50) = 3.9 x 10 (-12) g/mL, 9.5 pmol/L) of glomerular mesangial cell proliferation caused by high-ambient glucose (5.6 mM vs. 25 mM), and its inhibitory potency was about 1,000 times higher than that of simvastatin, an HMG-CoA reductase inhibitor used as a positive control. alpha-Spinasterol also significantly reduced the increases of serum triglycerides, renal weight and urinary protein excretion in streptozotocin-induced diabetic mice, and these were comparable to the results observed in insulin-treated diabetic mice.
    CONCLUSIONS:
    Therefore, the results obtained in this study suggest that alpha-spinasterol has a significant therapeutic potential to modulate the development and/or progression of diabetic nephropathy.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.1993 mL 10.9963 mL 21.9925 mL 43.985 mL 54.9813 mL
    5 mM 0.4399 mL 2.1993 mL 4.3985 mL 8.797 mL 10.9963 mL
    10 mM 0.2199 mL 1.0996 mL 2.1993 mL 4.3985 mL 5.4981 mL
    50 mM 0.044 mL 0.2199 mL 0.4399 mL 0.8797 mL 1.0996 mL
    100 mM 0.022 mL 0.11 mL 0.2199 mL 0.4399 mL 0.5498 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    豆甾-4,22,25-三烯-3-酮; Stigmasta-4,22,25-trien-3-one CFN97408 848669-09-0 C29H44O = 408.7 5mg QQ客服:2932563308
    豆甾-4,22-二烯-3-酮; Stigmasta-4,22-dien-3-one CFN98934 55722-32-2 C29H46O = 410.7 5mg QQ客服:1413575084
    豆甾醇; Stigmasterol CFN97326 83-48-7 C29H48O = 412.7 20mg QQ客服:3257982914
    β-谷甾醇; Beta-Sitosterol CFN99916 83-46-5 C29H50O = 414.69 20mg QQ客服:1148253675
    β-谷甾基十六烷酸酯,棕榈酸谷甾醇酯; Sitosteryl palmitate CFN98235 2308-85-2 C45H80O2 = 653.1 5mg QQ客服:215959384
    豆甾-5,8-二烯-3-醇; Stigmasta-5,8-dien-3-ol CFN98959 570-72-9 C29H48O = 412.7 5mg QQ客服:3257982914
    alpha-菠菜甾醇; alpha-Spinasterol CFN98748 481-18-5 C29H48O = 412.7 10 mg QQ客服:1413575084
    alpha-菠菜甾醇乙酸酯; alpha-Spinasterol acetate CFN98692 4651-46-1 C31H50O2 = 454.7 5mg QQ客服:215959384
    alpha-波菜甾酮; alpha-Spinasterone CFN98243 23455-44-9 C29H46O = 410.7 5mg QQ客服:3257982914
    豆甾-4-烯-3-酮; Sitostenone CFN99073 1058-61-3 C29H48O = 412.7 5mg QQ客服:2159513211

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