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  • 灵芝酸Y

    Ganoderic acid Y

    产品编号 CFN90294
    CAS编号 86377-52-8
    分子式 = 分子量 C30H46O3 = 454.68
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Triterpenoids
    植物来源 The fruit body of Ganoderma lucidum
    产品名称 产品编号 CAS编号 包装 QQ客服
    灵芝酸Y CFN90294 86377-52-8 1mg QQ客服:215959384
    灵芝酸Y CFN90294 86377-52-8 5mg QQ客服:215959384
    灵芝酸Y CFN90294 86377-52-8 10mg QQ客服:215959384
    灵芝酸Y CFN90294 86377-52-8 20mg QQ客服:215959384
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    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
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    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
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    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
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    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.

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    PMID: 30417089
  • Shanghai University of TCM (China)
  • Uniwersytet Gdański (Poland)
  • University of Oslo (Norway)
  • Research Unit Molecular Epigenetics (MEG) (Germany)
  • Korea Institute of Oriental Medicine (Korea)
  • Istanbul University (Turkey)
  • Sri Ramachandra University (India)
  • VIB Department of Plant Systems Biology, UGent (PSB) (Belgium)
  • Mahatma Gandhi University (India)
  • Subang Jaya Medical Centre (Malaysia)
  • Chulalongkorn University (Thailand)
  • University of Mysore (India)
  • Fraunhofer-Institut für Molekularbiologie und Angewandte ?kologie IME (Germany)
  • Heidelberg University (Germany)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • BMC Complement Altern Med.2014, 14:352
  • Acta Agriculturae Scandinavica2015, 381-383
  • US20170000760 A12016, 42740
  • Plant Cell Tiss Org2017, 479-486
  • J Nat Med.2017, 71(2):457-462
  • Nutrients.2018, 10(12)
  • Yakugaku Zasshi.2018, 138(4):571-579
  • Cell.2018, 172(1-2):249-261
  • Food Quality and Safety2018, 2:213-219
  • Evid Based Complement Alternat Med.2018, 2018:1073509
  • Evid Based Complement Alternat Med.2018, 2018:4580627
  • Molecules.2018, 23(2)
  • Int J Mol Sci.2019, 20(8):E1855
  • Chemistry of Plant Materials.2019, 215-222
  • Molecules.2019, 24(16):E3003
  • Chemistry of Vegetable Raw Materials2019, 3:119-127
  • Phytother Res.2019, 33(3):676-689
  • Journal of Apiculture2019, 34(2):131-136
  • Chinese Pharmacological Bulletin2019, 35(8):1120-1125
  • Korean Journal of Pharmacognosy2019, 50(4):285-290
  • J Mol Histol.2019, 50(4):343-354
  • J Nat Prod.2019, 82(4):1002-1008
  • Sci Rep.2019, 9(1):6429
  • ...
  • 生物活性
    Description: Ganoderic acid Y significantly inhibits the replication of the viral RNA (vRNA) of EV71 replication through blocking EV71 uncoating.
    Targets: Antifection
    In vitro:
    Biochem Biophys Res Commun. 2014 Jul 4;449(3):307-12.
    Antiviral effects of two Ganoderma lucidum triterpenoids against enterovirus 71 infection.[Pubmed: 24845570]
    Enterovirus 71 (EV71) is a major causative agent for hand, foot and mouth disease (HFMD), and fatal neurological and systemic complications in children. However, there is currently no clinical approved antiviral drug available for the prevention and treatment of the viral infection.
    Here, we evaluated the antiviral activities of two Ganoderma lucidum triterpenoids (GLTs), Lanosta-7,9(11),24-trien-3-one,15;26-dihydroxy (GLTA) and Ganoderic acid Y (GLTB), against EV71 infection. The results showed that the two natural compounds display significant anti-EV71 activities without cytotoxicity in human rhabdomyosarcoma (RD) cells as evaluated by 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) cell proliferation assay. The mechanisms by which the two compounds affect EV71 infection were further elucidated by three action modes using Ribavirin, a common antiviral drug, as a positive control.
    The results suggested that GLTA and GLTB prevent EV71 infection through interacting with the viral particle to block the adsorption of virus to the cells. In addition, the interactions between EV71 virion and the compounds were predicated by computer molecular docking, which illustrated that GLTA and GLTB may bind to the viral capsid protein at a hydrophobic pocket (F site), and thus may block uncoating of EV71. Moreover, we demonstrated that GLTA and GLTB significantly inhibit the replication of the viral RNA (vRNA) of EV71 replication through blocking EV71 uncoating. Thus, GLTA and GLTB may represent two potential therapeutic agents to control and treat EV71 infection.
    Appl Environ Microbiol. 2005 Jul;71(7):3653-8.
    Effect of 26-oxygenosterols from Ganoderma lucidum and their activity as cholesterol synthesis inhibitors.[Pubmed: 16000773]
    Ganoderma lucidum is a medicinal fungus belonging to the Polyporaceae family which has long been known in Japan as Reishi and has been used extensively in traditional Chinese medicine.
    We report the isolation and identification of the 26-oxygenosterols ganoderol A, ganoderol B, ganoderal A, and Ganoderic acid Y and their biological effects on cholesterol synthesis in a human hepatic cell line in vitro.
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.1993 mL 10.9967 mL 21.9935 mL 43.987 mL 54.9837 mL
    5 mM 0.4399 mL 2.1993 mL 4.3987 mL 8.7974 mL 10.9967 mL
    10 mM 0.2199 mL 1.0997 mL 2.1993 mL 4.3987 mL 5.4984 mL
    50 mM 0.044 mL 0.2199 mL 0.4399 mL 0.8797 mL 1.0997 mL
    100 mM 0.022 mL 0.11 mL 0.2199 mL 0.4399 mL 0.5498 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    灵芝酸S; Ganoderic acid S CFN99066 104759-35-5 C30H44O3 = 452.7 5mg QQ客服:2932563308
    灵芝酸TN; Ganoderic acid TN CFN90298 112430-64-5 C32H48O5 = 512.73 5mg QQ客服:2932563308
    灵芝酸X; Ganoderic acid X CFN92996 86377-53-9 C32H48O5 = 512.72 5mg QQ客服:3257982914
    灵芝酸Jb; Ganoderic acid Jb CFN92997 112430-68-9 C30H46O4 = 470.68 5mg QQ客服:1413575084
    灵芝酸TR; Ganoderic acid TR CFN92235 862893-75-2 C30H44O4 = 468.7 5mg QQ客服:1148253675
    灵芝酸T-Q; Ganoderic acid T-Q CFN92237 112430-66-7 C32H46O5 = 510.7 5mg QQ客服:2159513211
    胭脂虫酸; Coccinic acid CFN99083 107783-45-9 C30H46O3 = 454.7 5mg QQ客服:215959384
    安五酸; Anwuweizonic acid CFN92727 117020-59-4 C30H46O3 = 454.7 5mg QQ客服:2932563308
    7-氧代-灵芝酸Z; 7-Oxo-ganoderic acid Z CFN92998 929248-72-6 C30H46O4 = 470.68 5mg QQ客服:3257982914
    灵芝酸DM; Ganoderic acid DM CFN99815 173075-45-1 C30H44O4 = 468.7 5mg QQ客服:2932563308





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