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  • 灵芝酸X

    Ganoderic acid X

    灵芝酸X
    产品编号 CFN92996
    CAS编号 86377-53-9
    分子式 = 分子量 C32H48O5 = 512.72
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Triterpenoids
    植物来源 The fruit body of Ganoderma lucidum
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    灵芝酸X CFN92996 86377-53-9 1mg QQ客服:2932563308
    灵芝酸X CFN92996 86377-53-9 5mg QQ客服:2932563308
    灵芝酸X CFN92996 86377-53-9 10mg QQ客服:2932563308
    灵芝酸X CFN92996 86377-53-9 20mg QQ客服:2932563308
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Charles University in Prague (Czech Republic)
  • University of Fribourg (Switzerland)
  • Universiti Sains Malaysia (Malaysia)
  • Semmelweis Unicersity (Hungary)
  • University of Hawaii Cancer Center (USA)
  • Monash University Malaysia (Malaysia)
  • Universidad Industrial de Santander (Colombia)
  • Yale University (USA)
  • University of Lodz (Poland)
  • Universit?t Basel (Switzerland)
  • University of Zurich (Switzerland)
  • University of Stirling (United Kingdom)
  • Universite de Lille1 (France)
  • Medizinische Universit?t Wien (Austria)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • BMC Complement Altern Med.2014, 14:352
  • Nat Prod Sci.2014, 20(3):182-190
  • University of Limpopo2016, 1-237
  • J of the Korean Society of Food Science and Nutrition2016, 45(7):1017-1025
  • Mol Pharm.2017, 14(9):3164-3177
  • Food Chem.2017, 221:1135-1144
  • Industrial Crops and Products2017, 95:286-295
  • Nutrients.2018, 10(12)
  • BMC Plant Biol.2018, 18(1):122
  • The Journal of Agromedicine and Medical Sciences2018, 4(1)
  • Pharmacol Rep.2018, 70(6):1195-1201
  • J of Health Science and Alternative Medicine2019, 1(1)
  • Front Pharmacol.2019, 10:1025
  • Front Microbiol.2019, 10:2806
  • Int J Mol Sci.2019, 20(23):E6071
  • Spectrochim Acta A2019, 210:372-380
  • Chemistry of Plant Materials.2019, 215-222
  • Molecules.2019, 24(9):E1719
  • Journal of Apiculture2019, 34(2):131-136
  • Int J Oncol.2019, 55(1):320-330
  • Planta Med.2019, 85(4):347-355
  • Sci Rep.2019, 9(1):4342
  • Biomolecules.2019, 9(11):E696
  • ...
  • 生物活性
    Description: Ganoderic acid X is a potential Mdm2 inhibitor(K(i) = 16nM). It is a potential anticancer drug, inhibits topoisomerases and induces apoptosis of cancer cells.
    Targets: Mdm2 | p53 | ERK | JNK | MAPK | Caspase | Topoisomerase
    In vitro:
    Life Sci. 2005 Jun 3;77(3):252-65.
    Ganoderic acid X, a lanostanoid triterpene, inhibits topoisomerases and induces apoptosis of cancer cells.[Pubmed: 15878354 ]
    Lanostanoid triterpenes isolated from Ganoderma amboinense were found to inhibit the growth of numerous cancer cell lines, and some of them inhibited the activities of topoisomerases I and IIalpha in vitro.
    METHODS AND RESULTS:
    Among the bioactive isolates, one of the most potent triterpene was identified to be 3 alpha-hydroxy-15 alpha-acetoxy-lanosta-7,9(11),24-trien-26-oic acid, Ganoderic acid X (GAX). Treatment of human hepatoma HuH-7 cells with GAX caused immediate inhibition of DNA synthesis as well as activation of ERK and JNK mitogen-activated protein kinases, and cell apoptosis.
    CONCLUSIONS:
    Molecular events of apoptosis including degradation of chromosomal DNA, decrease in the level of Bcl-xL, the disruption of mitochondrial membrane, cytosolic release of cytochrome c and activation of caspase-3 were elucidated. The ability of GAX to inhibit topoisomerases and to sensitize the cancer cells toward apoptosis fulfills the feature of a potential anticancer drug.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.9504 mL 9.7519 mL 19.5038 mL 39.0076 mL 48.7596 mL
    5 mM 0.3901 mL 1.9504 mL 3.9008 mL 7.8015 mL 9.7519 mL
    10 mM 0.195 mL 0.9752 mL 1.9504 mL 3.9008 mL 4.876 mL
    50 mM 0.039 mL 0.195 mL 0.3901 mL 0.7802 mL 0.9752 mL
    100 mM 0.0195 mL 0.0975 mL 0.195 mL 0.3901 mL 0.4876 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    7-氧代-灵芝酸Z; 7-Oxo-ganoderic acid Z CFN92998 929248-72-6 C30H46O4 = 470.68 5mg QQ客服:1413575084
    灵芝酸DM; Ganoderic acid DM CFN99815 173075-45-1 C30H44O4 = 468.7 5mg QQ客服:215959384
    23S-羟基-11,15-二氧-灵芝酸DM; 23S-hydroxy-11,15-dioxo-ganoderic acid DM CFN80433 1085273-49-9 C30H40O7 = 512.63 5mg QQ客服:2932563308
    灵芝酸Y; Ganoderic acid Y CFN90294 86377-52-8 C30H46O3 = 454.68 5mg QQ客服:2159513211
    灵芝酸SZ; Ganoderic acid SZ CFN97426 865543-37-9 C30H44O3 = 452.7 5mg QQ客服:3257982914
    灵芝酸S; Ganoderic acid S CFN99066 104759-35-5 C30H44O3 = 452.7 5mg QQ客服:1413575084
    灵芝酸TN; Ganoderic acid TN CFN90298 112430-64-5 C32H48O5 = 512.73 5mg QQ客服:1148253675
    灵芝酸X; Ganoderic acid X CFN92996 86377-53-9 C32H48O5 = 512.72 5mg QQ客服:215959384
    灵芝酸Jb; Ganoderic acid Jb CFN92997 112430-68-9 C30H46O4 = 470.68 5mg QQ客服:1413575084
    灵芝酸TR; Ganoderic acid TR CFN92235 862893-75-2 C30H44O4 = 468.7 5mg QQ客服:1413575084

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