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  • 7-氧代-灵芝酸Z

    7-Oxo-ganoderic acid Z

    7-氧代-灵芝酸Z
    产品编号 CFN92998
    CAS编号 929248-72-6
    分子式 = 分子量 C30H46O4 = 470.68
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Triterpenoids
    植物来源 The fruit body of Ganoderma lucidum
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    7-氧代-灵芝酸Z CFN92998 929248-72-6 1mg QQ客服:1413575084
    7-氧代-灵芝酸Z CFN92998 929248-72-6 5mg QQ客服:1413575084
    7-氧代-灵芝酸Z CFN92998 929248-72-6 10mg QQ客服:1413575084
    7-氧代-灵芝酸Z CFN92998 929248-72-6 20mg QQ客服:1413575084
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of Medicine and Pharmacy (Romania)
  • Universidade Católica Portuguesa (Portugal)
  • Universidad de Antioquia (Colombia)
  • Subang Jaya Medical Centre (Malaysia)
  • Utah State University (USA)
  • Auburn University (USA)
  • University of British Columbia (Canada)
  • Monash University (Australia)
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  • University of Bordeaux (France)
  • Universiti Putra Malaysia(UPM) (Malaysia)
  • University of Canterbury (New Zealand)
  • Washington State University (USA)
  • Institute of Tropical Disease Universitas Airlangga (Indonesia)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Antiviral Res.2013, 98(3):386-93
  • The Journal of Internal Korean Medicine2015, 36(4):486-497
  • Biomed Chromatogr.2016, 30(10):1573-81
  • Int J Mol Med.2016, 37(2):501-8
  • J Pharm Anal.2016, 6(6):363-373
  • Org Biomol Chem.2017, 15(31):6483-6492
  • J Bone Miner Res.2017, 32(12):2415-2430
  • Sci Rep.2017, 7:40345
  • Journal of functional foods2018, 171-182
  • Curr Eye Res.2018, 43(1):27-34
  • Chemistry of Natural Compounds2018, 54(3):572–576
  • The Japan Society for Analytical Chemistry2018, 67(4):201-206
  • Sci Rep.2018, 8(1):12970
  • Biorxiv2019, 10.1101
  • APMIS.2019, 127(10):688-695
  • Int J Mol Sci.2019, 20(23):E6071
  • Trop J Nat Prod Res.2019, 3(1):6-9
  • FASEB J.2019, 33(2):2026-2036
  • FASEB J.2019, 33(8):9685-9694
  • Srinagarind Medical Journal2019, 34(1)
  • Phytomedicine.2019, 62:152962
  • Industrial Crops and Products2020, 146:112186
  • Pharmacological Reports2020, 1-9
  • ...
  • 生物活性
    Description: 7-Oxo-ganoderic acid Z shows strong inhibitory effects against α-glucosidase, it also exhibits inhibitory activities against the HMG-CoA reductase and acyl CoA acyltransferase. 7-Oxo-ganoderic acid Z can reduce cell growth in three human carcinoma cells (Caco-2, HepG2, and HeLa cells) dose dependently with LC50s from 20.87 to 84.36 uM.
    Targets: HMG-CoA Reductase
    In vitro:
    Phytochemistry. 2018 May;149:103-115.
    Lanostane triterpenes from the mushroom Ganoderma resinaceum and their inhibitory activities against α-glucosidase.[Pubmed: 29490285 ]
    Eighteen previously undescribed lanostane triterpenes and thirty known analogues were obtained from the fruiting bodies of Ganoderma resinaceum. Resinacein C was isolated from a natural source for the first time.
    METHODS AND RESULTS:
    The structures of all the above compounds were elucidated by extensive spectroscopic analysis and comparisons of their spectroscopic data with those reported in the literature. Furthermore, in an in vitro assay, Resinacein C, ganoderic acid Y, lucialdehyde C, 7-Oxo-ganoderic acid Z3, 7-Oxo-ganoderic acid Z, and lucidadiol showed strong inhibitory effects against α-glucosidase compared with the positive control drug acarbose.
    CONCLUSIONS:
    The structure-activity relationships of ganoderma triterpenes on α-glucosidase inhibition showed that the C-24/C-25 double bond is necessary for α-glucosidase inhibitory activity. Moreover, the carboxylic acid group at C-26 and the hydroxy group at C-15 play important roles in enhancing inhibitory effects of these triterpenes.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.1246 mL 10.6229 mL 21.2459 mL 42.4917 mL 53.1146 mL
    5 mM 0.4249 mL 2.1246 mL 4.2492 mL 8.4983 mL 10.6229 mL
    10 mM 0.2125 mL 1.0623 mL 2.1246 mL 4.2492 mL 5.3115 mL
    50 mM 0.0425 mL 0.2125 mL 0.4249 mL 0.8498 mL 1.0623 mL
    100 mM 0.0212 mL 0.1062 mL 0.2125 mL 0.4249 mL 0.5311 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    灵芝酸TN; Ganoderic acid TN CFN90298 112430-64-5 C32H48O5 = 512.73 5mg QQ客服:1148253675
    灵芝酸X; Ganoderic acid X CFN92996 86377-53-9 C32H48O5 = 512.72 5mg QQ客服:1413575084
    灵芝酸Jb; Ganoderic acid Jb CFN92997 112430-68-9 C30H46O4 = 470.68 5mg QQ客服:2159513211
    灵芝酸TR; Ganoderic acid TR CFN92235 862893-75-2 C30H44O4 = 468.7 5mg QQ客服:1413575084
    灵芝酸T-Q; Ganoderic acid T-Q CFN92237 112430-66-7 C32H46O5 = 510.7 5mg QQ客服:1413575084
    胭脂虫酸; Coccinic acid CFN99083 107783-45-9 C30H46O3 = 454.7 5mg QQ客服:1413575084
    安五酸; Anwuweizonic acid CFN92727 117020-59-4 C30H46O3 = 454.7 5mg QQ客服:1413575084
    7-氧代-灵芝酸Z; 7-Oxo-ganoderic acid Z CFN92998 929248-72-6 C30H46O4 = 470.68 5mg QQ客服:1413575084
    灵芝酸DM; Ganoderic acid DM CFN99815 173075-45-1 C30H44O4 = 468.7 5mg QQ客服:2159513211
    23S-羟基-11,15-二氧-灵芝酸DM; 23S-hydroxy-11,15-dioxo-ganoderic acid DM CFN80433 1085273-49-9 C30H40O7 = 512.63 5mg QQ客服:2159513211

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