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  • 灵芝酸T-Q

    Ganoderic acid T-Q

    灵芝酸T-Q
    产品编号 CFN92237
    CAS编号 112430-66-7
    分子式 = 分子量 C32H46O5 = 510.7
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Triterpenoids
    植物来源 The fruit body of Ganoderma lucidum
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    灵芝酸T-Q CFN92237 112430-66-7 1mg QQ客服:1413575084
    灵芝酸T-Q CFN92237 112430-66-7 5mg QQ客服:1413575084
    灵芝酸T-Q CFN92237 112430-66-7 10mg QQ客服:1413575084
    灵芝酸T-Q CFN92237 112430-66-7 20mg QQ客服:1413575084
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Universidad de Ciencias y Artes de Chiapas (Mexico)
  • Harvard University (USA)
  • Korea Food Research Institute(KFRI) (Korea)
  • University of Stirling (United Kingdom)
  • University of Lodz (Poland)
  • Institute of Bioorganic Chemistry Polish Academy of Sciences (Poland)
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  • Korea Institute of Oriental Medicine (Korea)
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  • University of Hawaii Cancer Center (USA)
  • Universite Libre de Bruxelles (Belgium)
  • Guangzhou Institutes of Biomedicine and Health (China)
  • Technical University of Denmark (Denmark)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Asian Journal of Chemistry2014, 26(8):2425
  • Anticancer Res.2014, 34(7):3505-9
  • Phytother Res.2015, 29(7):1088-96
  • Evid Based Complement Alternat Med.2016, 2016:4357656
  • Molecules.2017, 22(12)
  • Journal of Life Science2017, 233-240
  • Cytotechnology.2017, 69(5):765-773
  • Nat Chem Biol.2018, 14(8):760-763
  • European Journal of Integrative Medicine2018, 20:165-172
  • J Cell Mol Med.2018, 22(9):4236-4242
  • Cell Biochem Funct.2018, 36(6):303-311
  • J Sep Sci.2018, 41(7):1682-1690
  • Mol Cells.2018, 41(8):771-780
  • J Agric Food Chem.2018, 66(1):351-358
  • Sci Rep.2018, 8(1):12970
  • Biochemical Systematics and Ecology2018, 81
  • Food and Agriculture Org. Of the UN2019, 151-160
  • Nutr Metab (Lond).2019, 16:31
  • Asian Pac J Cancer Prev.2019, 20(1):65-72
  • J of Dentistry & Oral Health2019, 2641-1962
  • Phytother Res.2019, 33(4):1104-1113
  • Comput Biol Chem.2019, 83:107096
  • Plos One.2020, 10.1371
  • ...
  • 生物活性
    Description: Ganoderic acid T-Q and TR are two inhibitors of H5N1 and H1N1 NAs.
    Targets: H5N1 | H1N1
    In vitro:
    Scientific Reports, 2015, 5:13194.
    Inhibition of neuraminidase by Ganoderma triterpenoids and implications for neuraminidase inhibitor design.[Reference: WebLink]
    Neuraminidase (NA) inhibitors are the dominant antiviral drugs for treating influenza in the clinic. Increasing prevalence of drug resistance makes the discovery of new NA inhibitors a high priority.
    METHODS AND RESULTS:
    Thirty-one triterpenoids from the medicinal mushroom Ganoderma lingzhi were analyzed in an in vitro NA inhibition assay, leading to the discovery of ganoderic acid T-Q and TR as two inhibitors of H5N1 and H1N1 NAs. Structure-activity relationship studies revealed that the corresponding triterpenoid structure is a potential scaffold for the design of NA inhibitors. Using these triterpenoids as probes we found, through further in silico docking and interaction analysis, that interactions with the amino-acid residues Arg292 and/or Glu119 of NA are critical for the inhibition of H5N1 and H1N1.
    CONCLUSIONS:
    These findings should prove valuable for the design and development of NA inhibitors.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.9581 mL 9.7905 mL 19.581 mL 39.1619 mL 48.9524 mL
    5 mM 0.3916 mL 1.9581 mL 3.9162 mL 7.8324 mL 9.7905 mL
    10 mM 0.1958 mL 0.979 mL 1.9581 mL 3.9162 mL 4.8952 mL
    50 mM 0.0392 mL 0.1958 mL 0.3916 mL 0.7832 mL 0.979 mL
    100 mM 0.0196 mL 0.0979 mL 0.1958 mL 0.3916 mL 0.4895 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    7-氧代-灵芝酸Z; 7-Oxo-ganoderic acid Z CFN92998 929248-72-6 C30H46O4 = 470.68 5mg QQ客服:2932563308
    灵芝酸DM; Ganoderic acid DM CFN99815 173075-45-1 C30H44O4 = 468.7 5mg QQ客服:1148253675
    23S-羟基-11,15-二氧-灵芝酸DM; 23S-hydroxy-11,15-dioxo-ganoderic acid DM CFN80433 1085273-49-9 C30H40O7 = 512.63 5mg QQ客服:1148253675
    灵芝酸Y; Ganoderic acid Y CFN90294 86377-52-8 C30H46O3 = 454.68 5mg QQ客服:2159513211
    灵芝酸SZ; Ganoderic acid SZ CFN97426 865543-37-9 C30H44O3 = 452.7 5mg QQ客服:1413575084
    灵芝酸S; Ganoderic acid S CFN99066 104759-35-5 C30H44O3 = 452.7 5mg QQ客服:215959384
    灵芝酸TN; Ganoderic acid TN CFN90298 112430-64-5 C32H48O5 = 512.73 5mg QQ客服:2159513211
    灵芝酸X; Ganoderic acid X CFN92996 86377-53-9 C32H48O5 = 512.72 5mg QQ客服:3257982914
    灵芝酸Jb; Ganoderic acid Jb CFN92997 112430-68-9 C30H46O4 = 470.68 5mg QQ客服:1413575084
    灵芝酸TR; Ganoderic acid TR CFN92235 862893-75-2 C30H44O4 = 468.7 5mg QQ客服:1413575084

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