• 中药标准品生产商,产品定制服务
  • 灵芝酸S

    Ganoderic acid S

    灵芝酸S
    产品编号 CFN99066
    CAS编号 104759-35-5
    分子式 = 分子量 C30H44O3 = 452.7
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Triterpenoids
    植物来源 The fruit body of Ganoderma lucidum.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    灵芝酸S CFN99066 104759-35-5 1mg QQ客服:2932563308
    灵芝酸S CFN99066 104759-35-5 5mg QQ客服:2932563308
    灵芝酸S CFN99066 104759-35-5 10mg QQ客服:2932563308
    灵芝酸S CFN99066 104759-35-5 20mg QQ客服:2932563308
    存储与注意事项
    1. 在您收到产品后请检查产品。如无问题,请将产品存入冰霜并且样品瓶保持密封,产品可以存放长达24个月(2-8摄氏度)。

    2. 只要有可能,产品溶解后,您应该在同一天应用于您的实验。 但是,如果您需要提前做预实验,或者需要全部溶解,我们建议您将溶液以等分试样的形式存放在-20℃的密封小瓶中。 通常,这些可用于长达两周。 使用前,打开样品瓶前,我们建议您将产品平衡至室温至少1小时。

    3. 需要更多关于溶解度,使用和处理的建议? 请发送电子邮件至:service@chemfaces.com
    订购流程
  • 1. 在线订购
  • 请联系我们QQ客服

  • 2. 电话订购
  • 请拨打电话:
    027-84237683 或 027-84237783

  • 3. 邮件或传真订购
  • 发送电子邮件到: manager@chemfaces.com 或
    发送传真到:027-84254680

  • 提供订购信息
  • 为了方便客户的订购,请需要订购ChemFaces产品的客户,在下单的时候请提供下列信息,以供我们快速为您建立发货信息。
  •  
  • 1. 产品编号(CAS No.或产品名称)
  • 2. 发货地址
  • 3. 联系方法 (联系人,电话)
  • 4. 开票抬头 (如果需要发票的客户)
  • 5. 发票地址(发货地址与发票地址不同)
  • 发货时间
    1. 付款方式为100%预付款客户,我们将在确认收到货款后当天或1-3个工作日发货。

    2. 付款方式为月结的客户,我们承诺在收到订单后当天或1-3个工作日内发货。

    3. 如果客户所需要的产品,需要重新生产,我们有权告知客户,交货时间需要延期。
    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Max Rubner-Institut (MRI) (Germany)
  • Universidade Católica Portuguesa (Portugal)
  • Universite Libre de Bruxelles (Belgium)
  • Siksha O Anusandhan University (India)
  • Texas A&M University (USA)
  • University of Hertfordshire (United Kingdom)
  • University of Eastern Finland (Finland)
  • National Cancer Center Research Institute (Japan)
  • University of Stirling (United Kingdom)
  • Gyeongsang National University (Korea)
  • Biotech R&D Institute (USA)
  • Leibniz Institute of Plant Biochemistry (Germany)
  • Aarhus University (Denmark)
  • University of East Anglia (United Kingdom)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Inflammation.2015, 38(4):1502-16
  • Molecules.2016, 21(6)
  • Chem Biol Interact.2016, 258:59-68
  • Chemistry of Plant Materials.2016, 33-46
  • Planta Med.2016, 82(13):1208-16
  • Acta Pharmaceutica Hungarica2016, 86:35-40
  • Food and Bioprocess Technology2017, 10(6):1074-1092
  • J Ethnopharmacol.2017, 198:87-90
  • Cell Physiol Biochem.2017, 43(4):1425-1435
  • J Hematol Oncol.2018, 11(1):112
  • Int J Mol Sci.2018, 19(9):E2601
  • Korean J of Medicinal Crop Science2018, 220-226
  • Phytomedicine.2018, 38:12-23
  • J of the Korean Society of Cosmetics and Cosmetology2018, 399-406
  • Food and Fermentation Industries2018, 44(371)
  • Pathogens.2018, 7(3):E62
  • J Nat Med.2018, 72(3):734-744
  • Drug Invention Today2019, 12(6):1303-1306
  • Food Res Int.2019, 123:125-134
  • Chemistry of Plant Materials.2019, 215-222
  • Academic J of Second Military Medical University2019, 40(1)
  • TCI CO.2019, US20190151257A1
  • LWT-Food Sci Technol2020, 109163
  • ...
  • 生物活性
    Description: A novel combination of triterpenoids includes at least ganoderic acid S (GAS), ganoderic acid T (GAT), ganoderic acid Me (GAMe), ganoderic acid R (GAR), and ganodermic acid S (GMAS), the composition is suitable for the treatment or prophylaxis of colon cancer, hepatic cancer, breast cancer, lung cancer or leukemia. Ganoderic acid S and Mf induce mitochondria mediated apoptosis in human cervical carcinoma HeLa cells.
    In vitro:
    US20140294753[P]. 2014.
    Therapeutic Composition for Treating Cancers.[Reference: WebLink]
    Disclosed herein is a composition that includes a novel combination of triterpenoids for the treatment or prophylaxis of a cancer. The triterpenoids includes at least ganoderic acid S (GAS), ganoderic acid T (GAT), ganoderic acid Me (GAMe), ganoderic acid R (GAR), and ganodermic acid S (GMAS). The composition is suitable for the treatment or prophylaxis of colon cancer, hepatic cancer, breast cancer, lung cancer or leukemia.
    Phytomedicine. 2011 Mar 15;18(5):349-55.
    Ganoderic acid Mf and S induce mitochondria mediated apoptosis in human cervical carcinoma HeLa cells.[Pubmed: 21036023 ]

    METHODS AND RESULTS:
    In this work, the effects of a pair of positional isomer of ganoderic acids (GAs), namely ganoderic acid Mf (GA-Mf) and Ganoderic acid S (GA-S) purified from the fermented mycelia of Ganoderma lucidum, on induction of cell apoptosis and the apoptotic pathway in HeLa cells were investigated. The results demonstrate that both isomers decreased cell population growth on various human carcinoma cell lines by MTT assay, while GA-Mf had better selectivity between normal and cancer cells. The flow cytometry analysis indicated that treatment of HeLa cells with GA-S caused cell cycle arrest in the S phase, while GA-Mf caused cell cycle arrest in the G1 phase. Compared with GA-S, GA-Mf had more potent increase in the number of early and late apoptotic cells. Treatment of HeLa cells with each isomer decreased the mitochondria membrane potential and caused the release of cytochrome c from mitochondria into the cytosol. In addition, stimulation of caspase-3 and caspase-9 activity was observed. The Bax/Bcl-2 ratio was also increased in GA-treated HeLa cells. The results demonstrated that both isomers GA-Mf and GA-S induced apoptosis of human HeLa cells through a mitochondria mediated pathway, but they had the different cell cycle arrest specificity.
    CONCLUSIONS:
    The findings will be helpful to the development of useful cancer chemopreventive compounds from G. lucidum.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.209 mL 11.0448 mL 22.0897 mL 44.1794 mL 55.2242 mL
    5 mM 0.4418 mL 2.209 mL 4.4179 mL 8.8359 mL 11.0448 mL
    10 mM 0.2209 mL 1.1045 mL 2.209 mL 4.4179 mL 5.5224 mL
    50 mM 0.0442 mL 0.2209 mL 0.4418 mL 0.8836 mL 1.1045 mL
    100 mM 0.0221 mL 0.1104 mL 0.2209 mL 0.4418 mL 0.5522 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    胭脂虫酸; Coccinic acid CFN99083 107783-45-9 C30H46O3 = 454.7 5mg QQ客服:1413575084
    安五酸; Anwuweizonic acid CFN92727 117020-59-4 C30H46O3 = 454.7 5mg QQ客服:1413575084
    7-氧代-灵芝酸Z; 7-Oxo-ganoderic acid Z CFN92998 929248-72-6 C30H46O4 = 470.68 5mg QQ客服:1148253675
    灵芝酸DM; Ganoderic acid DM CFN99815 173075-45-1 C30H44O4 = 468.7 5mg QQ客服:3257982914
    23S-羟基-11,15-二氧-灵芝酸DM; 23S-hydroxy-11,15-dioxo-ganoderic acid DM CFN80433 1085273-49-9 C30H40O7 = 512.63 5mg QQ客服:1413575084
    灵芝酸Y; Ganoderic acid Y CFN90294 86377-52-8 C30H46O3 = 454.68 5mg QQ客服:2159513211
    灵芝酸SZ; Ganoderic acid SZ CFN97426 865543-37-9 C30H44O3 = 452.7 5mg QQ客服:2159513211
    灵芝酸S; Ganoderic acid S CFN99066 104759-35-5 C30H44O3 = 452.7 5mg QQ客服:2932563308
    灵芝酸TN; Ganoderic acid TN CFN90298 112430-64-5 C32H48O5 = 512.73 5mg QQ客服:1413575084
    灵芝酸X; Ganoderic acid X CFN92996 86377-53-9 C32H48O5 = 512.72 5mg QQ客服:1413575084

    信息支持


    公司简介
    订购流程
    付款方式
    退换货政策

    ChemFaces提供的产品仅用于科学研究使用,不用于诊断或治疗程序。

    联系方式


    电机:027-84237783
    传真:027-84254680
    在线QQ: 215959384
    E-Mail:manager@chemfaces.com

    湖北省武汉沌口经济技术开区车城南路83号1号楼第三层厂房


    ChemFaces为科学家,科研人员与企业提供快速的产品递送。我们通过瑞士SGS ISO 9001:2008质量体系认证天然化合物与对照品的研发和生产