藤黄酸

Gambogic acid

	产品编号	CFN90172
	CAS编号	2752-65-0
	分子式 = 分子量	C₃₈H₄₄O₈ = 628.75
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Miscellaneous
	植物来源	The herbs of Garcinia hanburyi Hook. f.
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产品名称	产品编号	CAS编号	包装	QQ客服
藤黄酸	CFN90172	2752-65-0	10mg	QQ客服：2056216494
藤黄酸	CFN90172	2752-65-0	20mg	QQ客服：2056216494
藤黄酸	CFN90172	2752-65-0	50mg	QQ客服：2056216494
藤黄酸	CFN90172	2752-65-0	100mg	QQ客服：2056216494

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Description:

Gambogic acid is a tissue-specific proteasome inhibitor, which has anticancer, anti-inflammatory, and anti-angiogenesis activities. Gambogic acid induces LRIG1 (leucine-rich repeat and Ig-like domain-containing-1) upregulation, which is responsible for EGFR (epidermal growth factor receptor) degradation and its downstream Akt/mTORC1 inhibition.

Targets:

In vitro:

Cell Biochem Biophys. 2013 Sep;67(1):199-206.

Gambogic acid sensitizes ovarian cancer cells to doxorubicin through ROS-mediated apoptosis.[Pubmed: 23436279]

Ovarian cancer is one human malignancy which has response portly to doxorubicin. The anti-cancer activity of gambogic acid has been tested in in vitro and in vivo studies.
METHODS AND RESULTS:
In this study, we showed that gambogic acid, a natural compound, could potentiate the anticancer activity of doxorubicin in ovarian cancer through ROS-mediated apoptosis. Platinum-resistant human ovarian cancer cell line (SKOV-3) was treated with gambogic acid, doxorubicin, or the combination of both to investigate cell proliferation and apoptosis. We found that the combination of gambogic acid and doxorubicin causes synergistic loss of cell viability in SKOV-3 cells and this synergistic effect correlated with increased cellular ROS accumulation. Moreover, in vivo results showed that gambogic acid and doxorubicin combination resulted in a synergistic suppressing effect on tumor growth in ovarian cancer mice model.
CONCLUSIONS:
Taken together, the results suggested that doxorubicin in combination with gambogic acid might provide a promising therapeutic strategy to enhance chemosensitivity of ovarian cancer to doxorubicin.

Cancer Res. 2008 Mar 15;68(6):1843-50.

Gambogic acid inhibits angiogenesis and prostate tumor growth by suppressing vascular endothelial growth factor receptor 2 signaling.[Pubmed: 18339865 ]

Gambogic acid (GA), the main active compound of Gamboge hanburyi, has been previously reported to activate apoptosis in many types of cancer cell lines by targeting transferrin receptor and modulating nuclear factor-kappaB signaling pathway. Whether GA inhibits angiogenesis, which is crucial for cancer and other human diseases, remains unknown.
METHODS AND RESULTS:
Here, we found that GA significantly inhibited human umbilical vascular endothelial cell (HUVEC) proliferation, migration, invasion, tube formation, and microvessel growth at nanomolar concentration. In a xenograft prostate tumor model, we found that GA effectively inhibited tumor angiogenesis and suppressed tumor growth with low side effects using metronomic chemotherapy with GA. GA was more effective in activating apoptosis and inhibiting proliferation and migration in HUVECs than in human prostate cancer cells (PC3), suggesting GA might be a potential drug candidate in cancer therapy through angioprevention with low chemotoxicity. Furthermore, we showed that GA inhibited the activations of vascular endothelial growth factor receptor 2 and its downstream protein kinases, such as c-Src, focal adhesion kinase, and AKT.
CONCLUSIONS:
Together, these data suggest that GA inhibits angiogenesis and may be a viable drug candidate in antiangiogenesis and anticancer therapies.

In vivo:

Mediators Inflamm. 2014;2014:195327.

Potent anti-inflammatory and antiproliferative effects of gambogic acid in a rat model of antigen-induced arthritis.[Pubmed: 24623960]

We have previously reported a continuous activation of caspase-1 and increased interleukin (IL)-1β levels in early rheumatoid arthritis (RA). These observations raised the hypothesis that drugs targeting the IL-1β pathway, in addition to tumour necrosis factor (TNF), may be particularly effective for early RA treatment. We have recently identified gambogic acid as a promising therapeutic candidate to simultaneously block IL-1β and TNF secretion. Our main goal here was to investigate whether gambogic acid administration was able to attenuate inflammation in antigen-induced arthritis (AIA) rats.
METHODS AND RESULTS:
Gambogic acid was administered to AIA rats in the early and late phases of arthritis. The inflammatory score, ankle perimeter, and body weight were evaluated during the period of treatment. Rats were sacrificed after 19 days of disease progression and paw samples were collected for histological and immunohistochemical evaluation. We found that inflammation in joints was significantly suppressed following gambogic acid administration. Histological and immunohistochemical evaluation of treated rats revealed normal joint structures with complete abrogation of the inflammatory infiltrate and cellular proliferation.
CONCLUSIONS:
Our results suggest that gambogic acid has significant anti-inflammatory properties and can possibly constitute a prototype anti-inflammatory drug with therapeutic efficacy in the treatment of inflammatory diseases such as RA.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
Isogambogenin; Isogambogenin	CFN92086	173938-23-3	C₃₈H₄₆O₇ = 614.8	5mg	QQ客服：215959384
Desoxygambogenin; Desoxygambogenin	CFN92088	173614-93-2	C₃₈H₄₈O₆ = 600.8	10mg	QQ客服：2159513211
异新藤黄酸; Isogambogenic acid	CFN92096	887923-47-9	C₃₈H₄₆O₈ = 630.8	5mg	QQ客服：2056216494
新藤黄酸; Gambogenic acid	CFN92097	173932-75-7	C₃₈H₄₆O₈ = 630.8	20mg	QQ客服：1413575084
10-甲氧基新藤黄酸; 10-Methoxygambogenic acid	CFN95450	2095102-72-8	C₃₉H₅₀O₉ = 662.8	10mg	QQ客服：1413575084
藤黄酸; Gambogic acid	CFN90172	2752-65-0	C₃₈H₄₄O₈ = 628.75	20mg	QQ客服：215959384
新藤黄酸; Neogambogic acid	CFN90175	93772-31-7	C₃₈H₄₆O₉ = 646.77	20mg	QQ客服：1413575084
异藤黄酸; Isogambogic acid	CFN95440	149655-52-7	C₃₈H₄₄O₈ = 628.8	10mg	QQ客服：1413575084
Gambogin; Gambogin	CFN92089	173792-67-1	C₃₈H₄₆O₆ = 598.8	5mg	QQ客服：1413575084
表藤黄酸; Epigambogic acid	CFN92098	887606-04-4	C₃₈H₄₄O₈ = 628.8	10mg	QQ客服：2056216494

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.5905 mL	7.9523 mL	15.9046 mL	31.8091 mL	39.7614 mL
5 mM	0.3181 mL	1.5905 mL	3.1809 mL	6.3618 mL	7.9523 mL
10 mM	0.159 mL	0.7952 mL	1.5905 mL	3.1809 mL	3.9761 mL
50 mM	0.0318 mL	0.159 mL	0.3181 mL	0.6362 mL	0.7952 mL
100 mM	0.0159 mL	0.0795 mL	0.159 mL	0.3181 mL	0.3976 mL

藤黄酸

Gambogic acid

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