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  • 异新藤黄酸

    Isogambogenic acid

    异新藤黄酸
    产品编号 CFN92096
    CAS编号 887923-47-9
    分子式 = 分子量 C38H46O8 = 630.8
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Miscellaneous
    植物来源 The herbs of Garcinia hanburyi Hook. f.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    异新藤黄酸 CFN92096 887923-47-9 1mg QQ客服:2159513211
    异新藤黄酸 CFN92096 887923-47-9 5mg QQ客服:2159513211
    异新藤黄酸 CFN92096 887923-47-9 10mg QQ客服:2159513211
    异新藤黄酸 CFN92096 887923-47-9 20mg QQ客服:2159513211
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Melbourne University (Australia)
  • Universidade Católica Portuguesa (Portugal)
  • Utah State University (USA)
  • University of South Australia (Australia)
  • Heinrich-Heine-University Düsseldorf (Germany)
  • University of Leipzig (Germany)
  • University of Malaya (Malaysia)
  • Kyushu University (Japan)
  • National Cancer Institute (USA)
  • University of Virginia (USA)
  • Universidad de Ciencias y Artes de Chiapas (Mexico)
  • Instytut Nawozów Sztucznych w Pu?awach (Poland)
  • University of Maryland School of Medicine (USA)
  • Shanghai Institute of Organic Chemistry (China)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Mol Med Rep.2015, 12(5):7789-95
  • SBRAS2016, 12
  • Evid Based Complement Alternat Med.2016, 2016:4357656
  • Nat Plants.2016, 3:16205
  • Braz J Med Biol Res. 2016, 49(7)
  • Free Radic Biol Med.2016, 97:307-319
  • J Biochem Mol Toxicol.2017, 31(9)
  • Oncotarget.2017, 8(64):108006-108019
  • J Sci Food Agric.2017, 97(5):1656-1662
  • Nutrients.2018, 10(7)
  • Food Res Int.2018, 106:909-919
  • Molecules.2018, 23(7):E1659
  • Anticancer Res.2018, 38(4):2127-2135
  • Korean Journal of Pharmacognosy2018, 49(1):76-83
  • Chemistry of Natural Compounds2018, 54(3):572–576
  • BMC Complement Altern Med.2019, 19(1):367
  • Molecules.2019, 24(16):E2985
  • Molecules.2019, 24(24):E4536
  • J of Dentistry & Oral Health2019, 2641-1962
  • Food Chem.2019, 279:80-87
  • Toxicol Res.2019, 35(4):371-387
  • Biomed Chromatogr.2019, 8:e4774
  • Plant Growth Regulation2020, 90(2):383-392
  • ...
  • 生物活性
    Description: Isogambogenic acid inhibits angiogenesis and may be a viable drug candidate in anti-angiogenesis therapy. Isogambogenic acid exhibits an anticancer effect by inducing autophagy-dependent cell death in NSCLC cells, which may be an effective chemotherapeutic agent that can be used against NSCLC in a clinical setting.
    Targets: Bcl-2/Bax | Caspase | mTOR | VEGFR | Akt | MAPK
    In vitro:
    Sci Rep. 2015 Jan 9;5:7697.
    Isogambogenic acid induces apoptosis-independent autophagic cell death in human non-small-cell lung carcinoma cells.[Pubmed: 25571970]
    To overcome drug resistance caused by apoptosis deficiency in patients with non-small cell lung carcinoma (NSCLC), there is a need to identify other means of triggering apoptosis-independent cancer cell death. We are the first to report that isogambogenic acid (iso-GNA) can induce apoptosis-independent autophagic cell death in human NSCLC cells.
    METHODS AND RESULTS:
    Several features of the iso-GNA-treated NSCLC cells indicated that iso-GNA induced autophagic cell death. First, there was no evidence of apoptosis or cleaved caspase 3 accumulation and activation. Second, iso-GNA treatment induced the formation of autophagic vacuoles, increased LC3 conversion, caused the appearance of autophagosomes and increased the expression of autophagy-related proteins. These findings provide evidence that iso-GNA induces autophagy in NSCLC cells. Third, iso-GNA-induced cell death was inhibited by autophagic inhibitors or by selective ablation of Atg7 and Beclin 1 genes. Furthermore, the mTOR inhibitor rapamycin increased iso-GNA-induced cell death by enhancing autophagy. Finally, a xenograft model provided additional evidence that iso-GNA exhibited anticancer effect through inducing autophagy-dependent cell death in NSCLC cells.
    CONCLUSIONS:
    Taken together, our results demonstrated that iso-GNA exhibited an anticancer effect by inducing autophagy-dependent cell death in NSCLC cells, which may be an effective chemotherapeutic agent that can be used against NSCLC in a clinical setting.
    J Chemother. 2013 Oct;25(5):298-308.
    Isogambogenic acid inhibits tumour angiogenesis by suppressing Rho GTPases and vascular endothelial growth factor receptor 2 signalling pathway.[Pubmed: 24070138]
    Isogambogenic acid (iso-GNA) is a well-known herbal medicine extracted from Garcinia hanburyi. This study carried out in vitro and in vivo evaluations of the anti-tumour and anti-angiogenic activity of Isogambogenic acid and underlying mechanisms.
    METHODS AND RESULTS:
    A standard methyl thiazolyl tetrazolium assay showed that Isogambogenic acid was more effective in inhibiting the proliferation of human umbilical vascular endothelial cells than A549 cancer cells. Isogambogenic acid demonstrated potent anti-angiogenic activity and low toxicity at appropriate concentrations in zebrafish embryos. In a xenograft nude mouse model of lung tumour, Isogambogenic acid effectively inhibited tumour growth and tumour angiogenesis. Isogambogenic acid suppressed neovascularization of implanted matrigel plugs in vivo and inhibited vascular endothelial growth factor (VEGF)-induced microvessel sprouting from mouse aortic rings ex vivo. Isogambogenic acid inhibited VEGF-induced migration, invasion, and tube formation in vitro and affected cytoskeletal rearrangement in human umbilical vascular endothelial cells. The results show that Isogambogenic acid suppressed angiogenesis-mediated tumour growth by targeting VEGFR2, Akt, mitogen-activated protein kinase, Rho GTPase, vascular endothelium-cadherin, and focal adhesion kinase signalling pathways.
    CONCLUSIONS:
    Together, these data suggest that Isogambogenic acid inhibits angiogenesis and may be a viable drug candidate in anti-angiogenesis and anti-cancer therapies.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.5853 mL 7.9264 mL 15.8529 mL 31.7058 mL 39.6322 mL
    5 mM 0.3171 mL 1.5853 mL 3.1706 mL 6.3412 mL 7.9264 mL
    10 mM 0.1585 mL 0.7926 mL 1.5853 mL 3.1706 mL 3.9632 mL
    50 mM 0.0317 mL 0.1585 mL 0.3171 mL 0.6341 mL 0.7926 mL
    100 mM 0.0159 mL 0.0793 mL 0.1585 mL 0.3171 mL 0.3963 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    新藤黄酸; Gambogenic acid CFN92097 173932-75-7 C38H46O8 = 630.8 10mg QQ客服:2932563308
    藤黄酸; Gambogic acid CFN90172 2752-65-0 C38H44O8 = 628.75 20mg QQ客服:2159513211
    新藤黄酸; Neogambogic acid CFN90175 93772-31-7 C38H46O9 = 646.77 20mg QQ客服:1148253675
    Gambogin; Gambogin CFN92089 173792-67-1 C38H46O6 = 598.8 5mg QQ客服:2932563308
    异藤黄酸; Isogambogic acid CFN92098 149655-52-7 C38H44O8 = 628.8 5mg QQ客服:215959384
    9R-10alpha-羟基表藤黄酸; 9R-10alpha-Hydroxyepigambogic acid CFN92099 1097882-33-1 C38H46O9 = 646.8 5mg QQ客服:2932563308
    9S-10alpha-羟基表藤黄酸; 9S-10alpha-Hydroxyepigambogic acid CFN92100 1164201-85-7 C38H46O9 = 646.8 5mg QQ客服:3257982914
    Gambogoic acid B; Gambogoic acid B CFN92957 887923-50-4 C40H50O9 = 674.82 5mg QQ客服:3257982914
    30-羟基藤黄酸; 30-Hydroxygambogic acid CFN92101 881027-36-7 C38H44O9 = 644.8 5mg QQ客服:215959384
    Isogambogenin; Isogambogenin CFN92086 173938-23-3 C38H46O7 = 614.8 5mg QQ客服:2159513211

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