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  • 新藤黄酸

    Neogambogic acid

    新藤黄酸
    产品编号 CFN90175
    CAS编号 93772-31-7
    分子式 = 分子量 C38H46O9 = 646.77
    产品纯度 >=98%
    物理属性 Yellow cryst.
    化合物类型 Miscellaneous
    植物来源 The herbs of Garcinia hanburyi Hook. f.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    新藤黄酸 CFN90175 93772-31-7 10mg QQ客服:1413575084
    新藤黄酸 CFN90175 93772-31-7 20mg QQ客服:1413575084
    新藤黄酸 CFN90175 93772-31-7 50mg QQ客服:1413575084
    新藤黄酸 CFN90175 93772-31-7 100mg QQ客服:1413575084
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of Hull (United Kingdom)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Int J Mol Sci. 2014, 15(5):8443-57
  • Fitoterapia.2015, 100:179-86
  • Molecules.2015, 20(10):19172-88
  • Acta Biochim Pol.2015, 62(2):253-8
  • Korean J. of Food Sci. and Tech2016, 172-177
  • J Ethnopharmacol.2016, 194:219-227
  • Nat Prod Sci.2016, 22(2)
  • Evid Based Complement Alternat Med.2017, 2017:1401279
  • Preprints2017, 2017120176
  • Drug Test Anal.2018, 10(10):1579-1589
  • Evid Based Complement Alternat Med.2018, 2018:3610494
  • Sci Rep. 2018, 462(8)
  • Planta Med.2018, 84(15):1101-1109
  • J of Health Science and Alternative Medicine2019, 1(1)
  • Saf Health Work.2019, 10(2):196-204
  • Nutrients.2019, 11(11):E2694
  • BMC Complement Altern Med.2019, 19(1):325
  • BMC Complement Altern Med.2019, 19(1):339
  • Evid Based Complement Alternat Med.2019, 2019:2135351
  • Phytomedicine.2019, 62:152962
  • Biomed Chromatogr.2019, 8:e4774
  • Metabolites.2019, 9(11):E271
  • Plant Foods Hum Nutr.2020, 10.1007
  • ...
  • 生物活性
    Description: Neogambogic acid , an active ingredient in garcinia, can inhibit the growth of some solid tumors and result in an anticancer effect, it may be responsible for the inhibition of proliferation of human breast cancer cell line MCF-7 cells.
    Targets: Bcl-2/Bax | Caspase | P450 (e.g. CYP17)
    In vitro:
    Acta Biochim Biophys Sin (Shanghai). 2011 Sep;43(9):698-702.
    The mechanism of neogambogic acid-induced apoptosis in human MCF-7 cells.[Pubmed: 21785112]
    Neogambogic acid (NGA), an active ingredient in garcinia, can inhibit the growth of some solid tumors and result in an anticancer effect. We hypothesize that NGA may be responsible for the inhibition of proliferation of human breast cancer cell line MCF-7 cells.
    METHODS AND RESULTS:
    To investigate its anticancer mechanism in vitro, MCF-7 cells were treated with various concentrations of NGA. Results of MTT (methyl thiazolyl tetrazolum) assay showed that treatment with NGA significantly reduced the proliferation of MCF-7 cells in a dose-dependent manner. NGA could increase the expression of the apoptosis-related proteins FasL, caspase-3, caspase-8, caspase-9, and Bax and decrease the expression of anti-apoptotic protein Bcl-2 accompanied by the mitochondrial transmembrane damage. The antiproliferative effect of NGA on MCF-7 cells is due to the G(0)/G(1) arrest, increased apoptosis and activation of Fas/FasL and cytochrome C pathway.
    CONCLUSIONS:
    These results provide an important insight into the cellular and molecular mechanisms through which NGA impairs the proliferation of breast cancer cells.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.5461 mL 7.7307 mL 15.4614 mL 30.9229 mL 38.6536 mL
    5 mM 0.3092 mL 1.5461 mL 3.0923 mL 6.1846 mL 7.7307 mL
    10 mM 0.1546 mL 0.7731 mL 1.5461 mL 3.0923 mL 3.8654 mL
    50 mM 0.0309 mL 0.1546 mL 0.3092 mL 0.6185 mL 0.7731 mL
    100 mM 0.0155 mL 0.0773 mL 0.1546 mL 0.3092 mL 0.3865 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    9S-10alpha-羟基表藤黄酸; 9S-10alpha-Hydroxyepigambogic acid CFN92100 1164201-85-7 C38H46O9 = 646.8 5mg QQ客服:2932563308
    Gambogoic acid B; Gambogoic acid B CFN92957 887923-50-4 C40H50O9 = 674.82 5mg QQ客服:1413575084
    30-羟基藤黄酸; 30-Hydroxygambogic acid CFN92101 881027-36-7 C38H44O9 = 644.8 5mg QQ客服:3257982914
    Isogambogenin; Isogambogenin CFN92086 173938-23-3 C38H46O7 = 614.8 5mg QQ客服:2159513211
    Desoxygambogenin; Desoxygambogenin CFN92088 173614-93-2 C38H48O6 = 600.8 5mg QQ客服:1148253675
    异新藤黄酸; Isogambogenic acid CFN92096 887923-47-9 C38H46O8 = 630.8 5mg QQ客服:3257982914
    新藤黄酸; Gambogenic acid CFN92097 173932-75-7 C38H46O8 = 630.8 10mg QQ客服:1148253675
    藤黄酸; Gambogic acid CFN90172 2752-65-0 C38H44O8 = 628.75 20mg QQ客服:2932563308
    新藤黄酸; Neogambogic acid CFN90175 93772-31-7 C38H46O9 = 646.77 20mg QQ客服:1148253675
    Gambogin; Gambogin CFN92089 173792-67-1 C38H46O6 = 598.8 5mg QQ客服:3257982914

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