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  • 新藤黄酸

    Gambogenic acid

    新藤黄酸
    产品编号 CFN92097
    CAS编号 173932-75-7
    分子式 = 分子量 C38H46O8 = 630.8
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Miscellaneous
    植物来源 The herbs of Garcinia hanburyi Hook. f.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    新藤黄酸 CFN92097 173932-75-7 1mg QQ客服:3257982914
    新藤黄酸 CFN92097 173932-75-7 5mg QQ客服:3257982914
    新藤黄酸 CFN92097 173932-75-7 10mg QQ客服:3257982914
    新藤黄酸 CFN92097 173932-75-7 20mg QQ客服:3257982914
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • St. Jude Children Research Hospital (USA)
  • University of Madras (India)
  • Universit?t Basel (Switzerland)
  • FORTH-IMBB (Greece)
  • Heidelberg University (Germany)
  • University of Wisconsin-Madison (USA)
  • University of Fribourg (Switzerland)
  • Funda??o Universitária de Desenvolvimento (Brazil)
  • Washington State University (USA)
  • University of Canterbury (New Zealand)
  • Kamphaengphet Rajabhat University (Thailand)
  • Vin?a Institute of Nuclear Sciences (Serbia)
  • University of Eastern Finland (Finland)
  • Deutsches Krebsforschungszentrum (Germany)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • J. Soc. Cosmet. Sci. Korea2016, 163-171
  • J Ethnopharmacol.2016, 194:219-227
  • Molecules.2016, 21(6)
  • Phytomedicine.2016, 23(4):331-9
  • Acta Chromatographica2016, 29(3)
  • Phytomedicine.2017, 24:77-86
  • FEMS Microbiol Lett.2017, 364(11)
  • Naunyn Schmiedebergs Arch Pharmacol.2017, 390(10):1073-1083
  • Universidade Estadual Paulista2017, 42785
  • J Agric Food Chem.2017, 65(13):2670-2676
  • The Japan Society for Analy. Chem.2017, 66(8):613-617
  • BMC Complement Altern Med.2018, 18(1):303
  • Biol Pharm Bull.2018, 41(11):1685-1693
  • J Agric Food Chem.2018, 66(1):351-358
  • Eur J Pharmacol.2018, 832:96-103
  • Front Pharmacol.2019, 10:1025
  • J Pharm Biomed Anal.2019, 172:268-277
  • Chemistry of Plant Materials.2019, 215-222
  • Phytomedicine.2019, 56:48-56
  • Phytomedicine.2019, 62:152962
  • Environ Toxicol Pharmacol.2019, 66:109-115
  • J of Ana. Chem.2019, 74(11):1113-1121
  • Sci Rep.2019, 9(1):18080
  • ...
  • 生物活性
    Description: Gambogenic acid is an inhibitor of the FGFR signaling pathway in erlotinib-resistant non-small-cell lung cancer (NSCLC) and exhibits anti-tumor effects, it can cause aberrant autophagy to induce cell death and may suggest the potential application of Gambogenic acid as a tool or viable drug in anticancer therapies.Gambogenic acid could inhibit the proliferation of melanoma B16 cells and induce their apoptosis within certain time and concentration ranges. Its mechanism in inducing the cell apoptosis may be related to PI3K/Akt/mTOR signaling pathways.
    Targets: Caspase | ROS | PI3K | Akt | mTOR | MMP(e.g.TIMP) | Bcl-2/Bax | FGFR | Autophagy
    In vitro:
    Zhong Yao Cai. 2014 Mar;37(3):469-73.
    Apoptosis of melanoma B16 cells induced by gambogenic acid.[Pubmed: 25174115]
    To study the inhibitory effect of Gambogenic acid (GNA) on melanoma B16 cells proliferation, and to explore the role of cell apoptosis.
    METHODS AND RESULTS:
    The inhibitory effect of Gambogenic acid on the proliferation of B16 cells was measured by methyl thiazolyl tetrazolium (MTT) assay; Alternation of B16 cells ultrastructure was detected by AO/EB staining under fluorescent microscope; Flow cytometry was used to detect intracellular reactive oxygen species (ROS) in B16 cells generated by Gambogenic acid treatment Western blotting was used to investigate the expression of intracellular Caspase-3 proteins changes. MTT results showed that the Gambogenic acid within a certain time and a certain concentration significantly suppressed the proliferation of B16 cells and morphological changes were observed by fluorescence microscope on B16 cells after Gambogenic acid treatment. AO/EB staining showed that the major cell density decreased. Gambogenic acid treated cells showed obvious apoptotic status. After the cells treated with Gambogenic acid, in a short period of time, intracellular ROS levels increased dramatically compared with the control group (P < 0.01), and the mitochondrial membrane had a low potential consistently. Western blotting results showed that changes of intracellular proteins expression in the release of Caspase-3 proteins expression levels were increased after Gambogenic acid treatment.
    CONCLUSIONS:
    Gambogenic acid can inhibit malignant melanoma B16 cells growth and proliferation and induce apoptosis within a certain time and at a certain concentration.
    In vivo:
    Asian Pac J Cancer Prev. 2013;14(12):7601-5.
    Gambogenic acid induction of apoptosis in a breast cancer cell line.[Pubmed: 24460340]
    Gambogenic acid is a major active compound of gamboge which exudes from the Garcinia hanburyi tree. Gambogenic acid anti-cancer activity in vitro has been reported in several studies, including an A549 nude mouse model. However, the mechanisms of action remain unclear.
    METHODS AND RESULTS:
    We used nude mouse models to detect the effect of Gambogenic acid on breast tumors, analyzing expression of apoptosis-related proteins in vivo by Western blotting. Effects on cell proliferation, apoptosis and apoptosis-related proteins in MDA-MB-231 cells were detected by MTT, flow cytometry and Western blotting. Inhibitors of caspase-3,-8,-9 were also used to detect effects on caspase family members. We found that Gambogenic acid suppressed breast tumor growth in vivo, in association with increased expression of Fas and cleaved caspase-3,-8,-9 and bax, as well as decrease in the anti-apoptotic protein bcl-2. Gambogenic acid inhibited cell proliferation and induced cell apoptosis in a concentration-dependent manner.
    CONCLUSIONS:
    Our observations suggested that Gambogenic acid suppressed breast cancer MDA-MB-231 cell growth by mediating apoptosis through death receptor and mitochondrial pathways in vivo and in vitro.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.5853 mL 7.9264 mL 15.8529 mL 31.7058 mL 39.6322 mL
    5 mM 0.3171 mL 1.5853 mL 3.1706 mL 6.3412 mL 7.9264 mL
    10 mM 0.1585 mL 0.7926 mL 1.5853 mL 3.1706 mL 3.9632 mL
    50 mM 0.0317 mL 0.1585 mL 0.3171 mL 0.6341 mL 0.7926 mL
    100 mM 0.0159 mL 0.0793 mL 0.1585 mL 0.3171 mL 0.3963 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    异藤黄酸; Isogambogic acid CFN92098 149655-52-7 C38H44O8 = 628.8 5mg QQ客服:215959384
    9R-10alpha-羟基表藤黄酸; 9R-10alpha-Hydroxyepigambogic acid CFN92099 1097882-33-1 C38H46O9 = 646.8 5mg QQ客服:1413575084
    9S-10alpha-羟基表藤黄酸; 9S-10alpha-Hydroxyepigambogic acid CFN92100 1164201-85-7 C38H46O9 = 646.8 5mg QQ客服:215959384
    Gambogoic acid B; Gambogoic acid B CFN92957 887923-50-4 C40H50O9 = 674.82 5mg QQ客服:2932563308
    30-羟基藤黄酸; 30-Hydroxygambogic acid CFN92101 881027-36-7 C38H44O9 = 644.8 5mg QQ客服:1413575084
    Isogambogenin; Isogambogenin CFN92086 173938-23-3 C38H46O7 = 614.8 5mg QQ客服:215959384
    Desoxygambogenin; Desoxygambogenin CFN92088 173614-93-2 C38H48O6 = 600.8 5mg QQ客服:215959384
    异新藤黄酸; Isogambogenic acid CFN92096 887923-47-9 C38H46O8 = 630.8 5mg QQ客服:1148253675
    新藤黄酸; Gambogenic acid CFN92097 173932-75-7 C38H46O8 = 630.8 10mg QQ客服:3257982914
    藤黄酸; Gambogic acid CFN90172 2752-65-0 C38H44O8 = 628.75 20mg QQ客服:1148253675

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