菊苣苷

Cichoriin

	产品编号	CFN95196
	CAS编号	531-58-8
	分子式 = 分子量	C₁₅H₁₆O₉ = 340.3
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Coumarins
	植物来源	The roots of Cichorium intybus
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
菊苣苷	CFN95196	531-58-8	10mg	QQ客服：1457312923
菊苣苷	CFN95196	531-58-8	20mg	QQ客服：1457312923
菊苣苷	CFN95196	531-58-8	50mg	QQ客服：1457312923
菊苣苷	CFN95196	531-58-8	100mg	QQ客服：1457312923

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Center for protein Engineering (CIP) (Belgium)

Florida A&M University (USA)

University of Malaya (Malaysia)

Siksha O Anusandhan University (India)

VIT University (India)

Max Rubner-Institut (MRI) (Germany)

Texas A&M University (USA)

Weizmann Institute of Science (Israel)

Utah State University (USA)

Regional Crop Research Institute (Korea)

Molecular Biology Institute of Barcelona (IBMB)-CSIC (Spain)

Deutsches Krebsforschungszentrum (Germany)

Sapienza University of Rome (Italy)

University of Brasilia (Brazil)

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Description:

Cichoriin is a photosensitive compound, it could be used as herbal photosensitizing agent in treating benign breast tumor in rats.

In vitro:

International Journal of Biological Chemistry, 2009, 3(1):11-17.

Cytoprotective Activity of Chemical Constituents Isolated from Streptomyces sp.[Reference: WebLink]

METHODS AND RESULTS:
Four flavonoids including kaempferol (1), isoscutellarin (2), umbelliferone (3) and cichoriin (4) have been isolated from Streptomyces sp. Tc052, an endophyte in the root tissue of Alpinia galanga Swartz. The evaluation for protective effect of compounds 1-4 against glutamate-induced cytotoxicity in hippocampal HT22 cell line was conducted, Compounds 1 and 2 showed significant effective protection ratios of 62.4+2.8 and 55.3+3.4%, respectively, at a concentration of 100 μM, whereas compounds 3-4 were inactive. Compounds 1 and 2 showed potent scavenging effects on DPPH radical exhibiting IC50 value of 60.74 and 75.65 μM, respectively.
CONCLUSIONS:
These results suggest that compounds 1 and 2 may possess the neuroprotective activity against oxdative cellular injuries.

In vivo:

Electromagn Biol Med. 2012 Dec;31(4):299-309.

Introducing Cichorium Pumilum as a potential therapeutical agent against drug-induced benign breast tumor in rats.[Pubmed: 22812448]

Cichorium Pumilum (chicory) is could be a promising cancer treatment in which a photosensitizing drug concentrates in benign tumor cells and activated by quanta at certain wavelength. Such activated extracts could lead to cell death and tumor ablation. Previous studies have shown that Cichorium Pumilum (chicory) contains photosensitive compounds such as cichoriin, anthocyanins, lactucin, and Lactucopicrin.
METHODS AND RESULTS:
In the present study, the protective effect of sun light-activated Cichorium against the dimethylbenz[a]anthracene (DMBA) induced benign breast tumors to female Sprague-Dawley rats was investigated. Chicory's extract has significantly increase P.carbonyl (PC) and malondialdehyde (MDA) and decreases the hepatic levels of total antioxidant capacity (TAC) and superoxide dismutase (SOD) in benign breast tumors-induced group compared to control. It also significantly decrease the number of estrogen receptors ER-positive cells in tumor masses.
CONCLUSIONS:
These results suggest that chicory extracts could be used as herbal photosensitizing agent in treating benign breast tumor in rats.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
异莨菪亭; Isoscopoletin	CFN97684	776-86-3	C₁₀H₈O₄ = 192.17	20mg	QQ客服：2159513211
6-甲氧基香豆素-7-0-beta-D-吡喃葡萄糖苷; Magnolioside	CFN90699	20186-29-2	C₁₆H₁₈O₉ = 354.3	10mg	QQ客服：1457312923
东莨菪内酯；莨菪亭; Scopoletin	CFN97494	92-61-5	C₁₀H₈O₄ = 192.2	20mg	QQ客服：1413575084
乙酸东莨菪素酯; Scopoletin acetate	CFN98951	56795-51-8	C₁₂H₁₀O₅ = 234.2	5mg	QQ客服：2056216494
6-甲氧基-7-异戊烯氧基香豆素; 7-O-Prenylscopoletin	CFN92639	13544-37-1	C₁₅H₁₆O₄ = 260.3	5mg	QQ客服：1457312923
7-香叶草氧基-6-甲氧基香豆素; 7-Geranyloxy-6-methoxycoumarin	CFN98348	28587-43-1	C₂₀H₂₄O₄ = 328.4	10mg	QQ客服：3257982914
菊苣苷; Cichoriin	CFN95196	531-58-8	C₁₅H₁₆O₉ = 340.3	20mg	QQ客服：1413575084
早开堇菜苷; Prionanthoside	CFN95206	161842-81-5	C₁₇H₁₈O₁₀ = 382.3	5mg	QQ客服：2056216494
东莨菪甙；东莨菪苷; Scopolin	CFN98887	531-44-2	C₁₆H₁₈O₉ = 354.3	20mg	QQ客服：2056216494
皮契荔技苷; Fabiatrin	CFN90807	18309-73-4	C₂₁H₂₆O₁₃ = 486.4	10mg	QQ客服：2056216494

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	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.9386 mL	14.6929 mL	29.3858 mL	58.7717 mL	73.4646 mL
5 mM	0.5877 mL	2.9386 mL	5.8772 mL	11.7543 mL	14.6929 mL
10 mM	0.2939 mL	1.4693 mL	2.9386 mL	5.8772 mL	7.3465 mL
50 mM	0.0588 mL	0.2939 mL	0.5877 mL	1.1754 mL	1.4693 mL
100 mM	0.0294 mL	0.1469 mL	0.2939 mL	0.5877 mL	0.7346 mL