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  • 6-甲氧基-7-异戊烯氧基香豆素

    7-O-Prenylscopoletin

    6-甲氧基-7-异戊烯氧基香豆素
    产品编号 CFN92639
    CAS编号 13544-37-1
    分子式 = 分子量 C15H16O4 = 260.3
    产品纯度 >=98%
    物理属性 Cryst.
    化合物类型 Coumarins
    植物来源 The herbs of Ptaeroxylon obliquum
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    6-甲氧基-7-异戊烯氧基香豆素 CFN92639 13544-37-1 1mg QQ客服:2056216494
    6-甲氧基-7-异戊烯氧基香豆素 CFN92639 13544-37-1 5mg QQ客服:2056216494
    6-甲氧基-7-异戊烯氧基香豆素 CFN92639 13544-37-1 10mg QQ客服:2056216494
    6-甲氧基-7-异戊烯氧基香豆素 CFN92639 13544-37-1 20mg QQ客服:2056216494
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Journal of Functional Foods2017, 30:30-38
  • J Pharmaceut Biomed2020, 178:112894
  • Antioxidants (Basel).2022, 11(12):2496.
  • Front Immunol. 2020, 11:62.
  • Molecules.2021, 26(9):2526.
  • J of Physics Conference Series2019, 1349(1)
  • Front Pharmacol.2019, 10:1226
  • Int J Mol Sci.2020, 21(7):2530.
  • Cells.2021, 10(10):2633.
  • Ann Transl Med.2019, 7(23):731
  • Evid Based Complement Alternat Med.2021, 2021:8847358.
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  • Pharmaceuticals (Basel).2021, 14(8):742.
  • Int J Mol Sci.2019, 20(16):E4015
  • Antioxidants (Basel).2021, 10(10):1620.
  • Biomed Chromatogr.2016, 30(10):1573-81
  • Int J Mol Sci.2021, 22(11):5503.
  • Molecules.2019, 24(17):E3127
  • J Chromatogr A.2017, 1518:46-58
  • Int J Mol Sci.2021, 22(12):6466.
  • BMC Complement Med Ther.2023, 23(1):264.
  • Molecules.2021, 26(8):2161.
  • Appl. Sci. 2021, 11(10),4666.
  • ...
  • 生物活性
    Description: 7-O-Prenylscopoletin and cedrelopsin show high antiproliferative activities against cancer cell lines.
    Targets: CDK | PLK
    In vitro:
    Planta Medica, 2012 , 78 (11) :1201-1201.
    Mechanistic study of O-methylcedrelopsin and dehydrogeijerin[Reference: WebLink]
    Plants that can survive in the harsh environment of South Texas have the potential to produce molecules with activity against diverse biological targets. The Mountain torchwood, Amyris madrensis, was evaluated because the crude lipophilic extract had potent activity against prostate cancer cells. Multiple cytotoxic compounds were isolated using bioassay guided fractionation including 14 previously identified coumarins. Two coumarins, O-methylcedrelopsin and dehydrogeijerin, were evaluated for antiproliferative activities against cancer cell lines. O-methylcedrelopsin has an IC50 of 7.8 and 27.8μM in HeLa and PC-3 cells respectively. Dehydrogeijerin also showed activity in the low micromolar range with an IC50 of 16.0μM in HeLa cells and 43.0μM in PC-3 cells. Both O-methylcedrelopsin and dehydrogeijerin caused a dose dependent accumulation of cells in G2/M as determined by flow cytometry. They have no effects on interphase microtubule structures or on the assembly of purified tubulin, suggesting a mechanism different from microtubule binding compounds. The compounds do however initiate the formation of abnormal mitotic spindles which closely resemble those formed following treatment of cells with mitotic kinase inhibitors. The hypothesis that O-methylcedrelopsin and dehydrogeijerin target mitotic kinases, specifically polo like kinase 1 (PLK1) or cyclin dependent kinase 1 (CDK1) is being tested. Two structurally similar coumarins, 7-O-prenylscopoletin and cedrelopsin, were also identified but they have 10-fold lower antiproliferative potency. These structures will be informative in defining the moieties optimal for inhibiting mitotic progression.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.8417 mL 19.2086 mL 38.4172 mL 76.8344 mL 96.043 mL
    5 mM 0.7683 mL 3.8417 mL 7.6834 mL 15.3669 mL 19.2086 mL
    10 mM 0.3842 mL 1.9209 mL 3.8417 mL 7.6834 mL 9.6043 mL
    50 mM 0.0768 mL 0.3842 mL 0.7683 mL 1.5367 mL 1.9209 mL
    100 mM 0.0384 mL 0.1921 mL 0.3842 mL 0.7683 mL 0.9604 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    早开堇菜苷; Prionanthoside CFN95206 161842-81-5 C17H18O10 = 382.3 5mg QQ客服:215959384
    东莨菪甙; 东莨菪苷; Scopolin CFN98887 531-44-2 C16H18O9 = 354.3 20mg QQ客服:215959384
    皮契荔技苷; Fabiatrin CFN90807 18309-73-4 C21H26O13 = 486.4 10mg QQ客服:1457312923
    滨蒿內酯; Scoparone CFN99314 120-08-1 C11H10O4 = 206.2 20mg QQ客服:2056216494
    瑞香苷; Daphnin CFN80132 486-55-5 C15H16O9 = 340.3 5mg QQ客服:3257982914
    瑞香素-7-甲醚; Daphnetin 7-methyl ether CFN90593 19492-03-6 C10H8O4 = 192.17 20mg QQ客服:2159513211
    7-羟基-8-甲氧基香豆素; Hydrangetin CFN89148 485-90-5 C10H8O4 = 192.17 5mg QQ客服:1413575084
    瑞香素二甲醚; Daphnetin dimethyl ether CFN90594 2445-80-9 C11H10O4 = 206.19 20mg QQ客服:3257982914
    4-甲基瑞香素; 4-Methyldaphnetin CFN93089 2107-77-9 C10H8O4 = 192.17 5mg QQ客服:2159513211
    5,7-二羟基-4-甲基香豆素; 5,7-Dihydroxy-4-methylcoumarin CFN93090 2107-76-8 C10H8O4 = 192.17 5mg QQ客服:2056216494

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