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  • 东莨菪甙; 东莨菪苷

    Scopolin

    东莨菪甙; 东莨菪苷
    产品编号 CFN98887
    CAS编号 531-44-2
    分子式 = 分子量 C16H18O9 = 354.3
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Coumarins
    植物来源 The herbs of Scopolia japonica.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
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    产品名称 产品编号 CAS编号 包装 QQ客服
    东莨菪甙; 东莨菪苷 CFN98887 531-44-2 10mg QQ客服:3257982914
    东莨菪甙; 东莨菪苷 CFN98887 531-44-2 20mg QQ客服:3257982914
    东莨菪甙; 东莨菪苷 CFN98887 531-44-2 50mg QQ客服:3257982914
    东莨菪甙; 东莨菪苷 CFN98887 531-44-2 100mg QQ客服:3257982914
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Worcester Polytechnic Institute (USA)
  • University of Cincinnati (USA)
  • CSIRO - Agriculture Flagship (Australia)
  • Julius Kühn-Institut (Germany)
  • University of Ioannina (Greece)
  • Johannes Gutenberg University Mainz (JGU) (Germany)
  • Florida A&M University (USA)
  • Universite Libre de Bruxelles (Belgium)
  • Sanford Burnham Prebys Medical Discovery Institute (USA)
  • University Medical Center Mainz (Germany)
  • Copenhagen University (Denmark)
  • Max-Planck-Insitut (Germany)
  • Universidade Federal de Santa Catarina (Brazil)
  • National Chung Hsing University (Taiwan)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Sci. Rep.2015, 14-23
  • Korean Herb. Med. Inf. 2016, 4(1):35-42
  • Food Chem.2017, 221:1135-1144
  • Food Chem.2017, 228:301-314
  • Pharmacol Rep.2017, 69(6):1224-1231
  • Nat Prod Commun.2018, 10.1177
  • PLoS One.2018, 13(3):e0193386
  • Mol Pharm.2018, 15(8):3285-3296
  • BMC Complement Altern Med.2018, 18(1):221
  • Int J Mol Sci.2018, 19(9):E2528
  • South African J of Plant&Soil2018, 29-32
  • Academic J of Second Military Medical University2018, 39(11)
  • Cancer Manag Res.2019, 11:483-500
  • Molecules.2019, 24(24):E4536
  • Molecules.2019, 24(6):E1155
  • The Malaysian journal of pathology2019, 41(3):243-251
  • Phytomedicine.2019, 57:95-104
  • Planta Med.2019, 85(3):217-224
  • Sci Rep.2019, 9:19059
  • Oxid Med Cell Longev2019, 9056845:13
  • Nutrients2020, 12(2):488
  • Food Res Int.2020, 128:108778
  • United States Patent Application2020, 20200038363
  • ...
  • 生物活性
    Description: Scopolin exhibits significant and dose-related antinociceptive effects, it is a potential acetylcholinesterase (AChE) inhibitor. Scopolin can reduce the clinical symptoms of rat AIA by inhibiting inflammation and angiogenesis, it may be a potent agent for angiogenesis related diseases.Scopolin and related coumarins has fungitoxic effect on Sclerotinia sclerotiorum, which is a way to overcome sunflower head rot.
    Targets: VEGFR | IL Receptor | AChR | Antifection
    In vivo:
    Int Immunopharmacol. 2009 Jul;9(7-8):859-69.
    Scopolin isolated from Erycibe obtusifolia Benth stems suppresses adjuvant-induced rat arthritis by inhibiting inflammation and angiogenesis.[Pubmed: 19327410]
    Despite scopolin is a main coumarin constituent in the stems of Erycibe obtusifolia Benth, a herb drug that has long been utilized in traditional Chinese medicine for the treatment of rheumatoid arthritis, little information is available about the pharmacological activities of this compound. The present study was performed to investigate the anti-rheumatic effects of scopolin in adjuvant-induced arthritis (AIA) in rats, and explore the underlying mechanisms of action in views of anti-inflammatory and anti-angiogenic properties in the synovial tissues.
    METHODS AND RESULTS:
    Scopolin (50, 100 mg/kg), injected intraperitoneally for 10 days from the onset of secondary response, significantly inhibited both inoculated and non-inoculated paw swelling as well as articular index scores in AIA. Meanwhile, the mean body weight of rats treated with scopolin was higher than that of model group. Rats treated with high dose of scopolin (100 mg/kg) preserved a nearly normal histological architecture of the joints and showed a significant reduction of the new blood vessels in the synovial tissues. Additionally, scopolin could reduce IL-6, VEGF and FGF-2 expressions in rat synovial tissues.
    CONCLUSIONS:
    In conclusion, scopolin can reduce the clinical symptoms of rat AIA by inhibiting inflammation and angiogenesis, and this compound may be a potent agent for angiogenesis related diseases and can serve as a structural base for screening more potent synthetic analogs.
    Euphytica, 2006, 147(3):451-460.
    Fungitoxic effect of scopolin and related coumarins on Sclerotinia sclerotiorum. A way to overcome sunflower head rot.[Reference: WebLink]
    The content of coumarins, as probable phytoalexins, was analysed in four sunflower genotypes that ranged in responses to head rot from highly susceptible to highly resistant.
    METHODS AND RESULTS:
    Low levels of all coumarins (scopolin, scopoletin and ayapin) were detected in the three most susceptible genotypes irrespective of time after inoculation. However, in the resistant genotype there was a clear time-dependent disease-induced increase of all coumarins that reached a maximum after 10–14 days. Detailed comparison of the most susceptible and the resistant genotype showed that in the resistant but not the susceptible, scopoletin peroxidase activity increased during the course of the experiment. Results confirmed a clear negative correlation between coumarin content and disease symptoms and in particular for scopolin. Furthermore we show for the first time that scopolin is inhibitory to Sclerotinia at similar doses to scopoletin.
    CONCLUSIONS:
    As scopolin is known to be less phytotoxic than ayapin and scopoletin, its accumulation may well confer head rot resistance with minimal plant damage and might be one of the bases for resistance to Sclerotinia.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.8225 mL 14.1123 mL 28.2247 mL 56.4493 mL 70.5617 mL
    5 mM 0.5645 mL 2.8225 mL 5.6449 mL 11.2899 mL 14.1123 mL
    10 mM 0.2822 mL 1.4112 mL 2.8225 mL 5.6449 mL 7.0562 mL
    50 mM 0.0564 mL 0.2822 mL 0.5645 mL 1.129 mL 1.4112 mL
    100 mM 0.0282 mL 0.1411 mL 0.2822 mL 0.5645 mL 0.7056 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    瑞香苷; Daphnin CFN80132 486-55-5 C15H16O9 = 340.3 5mg QQ客服:2159513211
    瑞香素-7-甲醚; Daphnetin 7-methyl ether CFN90593 19492-03-6 C10H8O4 = 192.17 20mg QQ客服:3257982914
    7-羟基-8-甲氧基香豆素; Hydrangetin CFN89148 485-90-5 C10H8O4 = 192.17 5mg QQ客服:2159513211
    瑞香素二甲醚; Daphnetin dimethyl ether CFN90594 2445-80-9 C11H10O4 = 206.19 10mg QQ客服:2932563308
    4-甲基瑞香素; 4-Methyldaphnetin CFN93089 2107-77-9 C10H8O4 = 192.17 5mg QQ客服:215959384
    5,7-二羟基-4-甲基香豆素; 5,7-Dihydroxy-4-methylcoumarin CFN93090 2107-76-8 C10H8O4 = 192.17 5mg QQ客服:2932563308
    6,7-二羟基香豆素; 6,7-Dihydroxycoumarin CFN99115 305-01-1 C9H6O4 = 178.14 20mg QQ客服:2932563308
    4-甲基七叶亭; 4-Methylesculetin CFN93058 529-84-0 C10H8O4 = 192.17 5mg QQ客服:1413575084
    秦皮甲素; Esculin CFN99114 531-75-9 C15H16O9 = 340.28 20mg QQ客服:215959384
    异莨菪亭; Isoscopoletin CFN97684 776-86-3 C10H8O4 = 192.17 20mg QQ客服:2932563308

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