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  • 异莨菪亭

    Isoscopoletin

    异莨菪亭
    产品编号 CFN97684
    CAS编号 776-86-3
    分子式 = 分子量 C10H8O4 = 192.17
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Coumarins
    植物来源 The herbs of Paederia scandens (Lour.) Merr
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    异莨菪亭 CFN97684 776-86-3 10mg QQ客服:2056216494
    异莨菪亭 CFN97684 776-86-3 20mg QQ客服:2056216494
    异莨菪亭 CFN97684 776-86-3 50mg QQ客服:2056216494
    异莨菪亭 CFN97684 776-86-3 100mg QQ客服:2056216494
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of Canterbury (New Zealand)
  • Universiti Malaysia Pahang (Malaysia)
  • Istanbul University (Turkey)
  • VIT University (India)
  • MTT Agrifood Research Finland (Finland)
  • University of British Columbia (Canada)
  • University of Oslo (Norway)
  • University of Toronto (Canada)
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  • Agricultural Research Organization (ARO) (Israel)
  • Sri Ramachandra University (India)
  • Universita' Degli Studi Di Cagliari (Italy)
  • Tokyo Woman's Christian University (Japan)
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  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Int J Biol Macromol.2020, 161:1230-1239.
  • Cell Physiol Biochem.2017, 43(4):1425-1435
  • Vietnam Journal of Food Control2022, 5(3):pp.390-401.
  • Front Cell Dev Biol.2020, 8:32.
  • Int J Mol Sci.2020, 21(24):9369.
  • Pharmacol Res.2022, 182:106346.
  • Front Pharmacol.2021, 12:770667.
  • Int J Mol Sci.2020, 21(9):3392.
  • Front Cell Dev Biol.2021, 9:588093.
  • Molecules.2019, 24(6):E1177
  • Pharmaceuticals (Basel).2022, 15(5):591.
  • Korean J. Medicinal Crop Sci.2018, 26(2):148-156
  • Biomed Pharmacother.2022, 146:112497.
  • Int J Mol Sci.2021, 22(2):770.
  • Nutrients.2019, 12(1):E40
  • J Ethnopharmacol.2017, 198:91-97
  • Biomolecules.2022, 12(12):1754.
  • Int. J. Mol. Sci. 2022, 23(3),1696.
  • Iranian J. Pharm. Res.2021, 20(4):59-70
  • Appl. Sci. 2021, 11(17),7829
  • Research on Crops.2017, 18(2)
  • Appl. Sci.2020, 10(20),7374.
  • University of Central Lancashire2017, 20472
  • ...
  • 生物活性
    Description: Isoscopoletin possesses inhibitory activity against hepatitis B virus (HBV) replication; it also shows substantial inhibition against multi-drug resistant CEM/ADR5000 cells and human CCRF-CEM leukaemia cells, with the IC50 value is 1.6 and 4.0 microM, respectively.
    Targets: HBV
    In vitro:
    Planta Med. 2006 Jul;72(9):862-4.
    Activity-guided isolation of scopoletin and isoscopoletin, the inhibitory active principles towards CCRF-CEM leukaemia cells and multi-drug resistant CEM/ADR5000 cells, from Artemisia argyi.[Pubmed: 16881019]

    METHODS AND RESULTS:
    The ethyl acetate extract of Artemisia argyi leaves showed substantial inhibition in a cell proliferation assay using human CCRF-CEM leukaemia cells. Bioassay-guided fractionation of the extract led to the isolation of scopoletin and isoscopoletin as the active principles. Their IC50 values were 2.6 and 4.0 microM, respectively. Additionally the two substances were tested against the multidrug resistant subline, CEM/ADR5000 where they both showed IC50 values of 1.6 microM.
    CONCLUSIONS:
    In contrast to the standard cytostatic drugs doxorubicin, vincristine, and paclitaxel, CEM/ADR5000 cells therefore did not exhibit cross-resistance to scopoletin and isoscopoletin.
    Planta Med. 2005 Dec;71(12):1128-33.
    Evaluation of antiviral activity of compounds isolated from Ranunculus sieboldii and Ranunculus sceleratus.[Pubmed: 16395649 ]

    METHODS AND RESULTS:
    Nineteen compounds isolated from Ranunculus sieboldii and Ranunculus sceleratus were tested for inhibitory effects on hepatitis B virus (HBV) and Herpes simplex virus type-1 (HSV-1). The results showed that apigenin 4'- O- alpha-rhamnopyranoside, apigenin 7- O- beta-glucopyranosyl-4'- O- alpha-rhamnopyranoside, tricin 7- O- beta-glucopyranoside, tricin, and isoscopoletin possessed inhibitory activity against HBV replication. Protocatechuyl aldehyde exhibited an inhibiting activity on HSV-1 replication.
    CONCLUSIONS:
    It is therefore suggested that further investigations on these bioactive compounds might be needed to discover and develop new antiviral agents.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 5.2037 mL 26.0186 mL 52.0373 mL 104.0745 mL 130.0931 mL
    5 mM 1.0407 mL 5.2037 mL 10.4075 mL 20.8149 mL 26.0186 mL
    10 mM 0.5204 mL 2.6019 mL 5.2037 mL 10.4075 mL 13.0093 mL
    50 mM 0.1041 mL 0.5204 mL 1.0407 mL 2.0815 mL 2.6019 mL
    100 mM 0.052 mL 0.2602 mL 0.5204 mL 1.0407 mL 1.3009 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    瑞香苷; Daphnin CFN80132 486-55-5 C15H16O9 = 340.3 5mg QQ客服:1413575084
    瑞香素-7-甲醚; Daphnetin 7-methyl ether CFN90593 19492-03-6 C10H8O4 = 192.17 20mg QQ客服:2056216494
    7-羟基-8-甲氧基香豆素; Hydrangetin CFN89148 485-90-5 C10H8O4 = 192.17 5mg QQ客服:2159513211
    瑞香素二甲醚; Daphnetin dimethyl ether CFN90594 2445-80-9 C11H10O4 = 206.19 20mg QQ客服:215959384
    4-甲基瑞香素; 4-Methyldaphnetin CFN93089 2107-77-9 C10H8O4 = 192.17 5mg QQ客服:1457312923
    5,7-二羟基-4-甲基香豆素; 5,7-Dihydroxy-4-methylcoumarin CFN93090 2107-76-8 C10H8O4 = 192.17 5mg QQ客服:3257982914
    6,7-二羟基香豆素; 6,7-Dihydroxycoumarin CFN99115 305-01-1 C9H6O4 = 178.14 20mg QQ客服:215959384
    4-甲基七叶亭; 4-Methylesculetin CFN93058 529-84-0 C10H8O4 = 192.17 5mg QQ客服:1413575084
    秦皮甲素; Esculin CFN99114 531-75-9 C15H16O9 = 340.28 20mg QQ客服:215959384
    异莨菪亭; Isoscopoletin CFN97684 776-86-3 C10H8O4 = 192.17 20mg QQ客服:2159513211

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