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  • 酸橙素烯醇

    Auraptenol

    酸橙素烯醇
    产品编号 CFN99340
    CAS编号 1221-43-8
    分子式 = 分子量 C15H16O4 = 260.3
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Coumarins
    植物来源 The fruits of Citrus aurantium
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    酸橙素烯醇 CFN99340 1221-43-8 1mg QQ客服:215959384
    酸橙素烯醇 CFN99340 1221-43-8 5mg QQ客服:215959384
    酸橙素烯醇 CFN99340 1221-43-8 10mg QQ客服:215959384
    酸橙素烯醇 CFN99340 1221-43-8 20mg QQ客服:215959384
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Universiti Malaysia Pahang (Malaysia)
  • Regional Crop Research Institute (Korea)
  • University of Malaya (Malaysia)
  • Universidad Veracuzana (Mexico)
  • Charles University in Prague (Czech Republic)
  • Ain Shams University (Egypt)
  • University of Padjajaran (Indonesia)
  • Centrum Menselijke Erfelijkheid (Belgium)
  • University of British Columbia (Canada)
  • The Vancouver Prostate Centre (VPC) (Canada)
  • Siksha O Anusandhan University (India)
  • St. Jude Children Research Hospital (USA)
  • Monash University (Australia)
  • Medical University of South Carolina (USA)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Korean Journal of Pharmacognosy2014, 113-120
  • J Breast Cancer.2015, 18(2):112-118
  • Mediators Inflamm. 2016, 2016:6189590
  • Molecules.2016, 21(6)
  • Planta Med.2016, 82(13):1208-16
  • J Pharm Biomed Anal.2017, 140:274-280
  • Food Chem.2017, 228:301-314
  • J Cell Biochem.2018, 119(2):2231-2239
  • Exp Parasitol.2018, 194:67-78
  • Evid Based Complement Alternat Med.2018, 2018:4580627
  • Chemistry of Natural Compounds2018, 204–206
  • Molecules.2018, 23(2)
  • Exp Neurobiol.2018, 27(3):200-209
  • Front Immunol.2018, 9:2091
  • Int J Biol Macromol.2019, 126:653-661
  • Chinese Medicine2019, 14(1)
  • Food and Agriculture Org. Of the UN2019, 151-160
  • Pak J Pharm Sci.2019, 32(6):2879-2885
  • Environ Toxicol.2019, 34(4):513-520.
  • Cell Mol Biol(Noisy-le-grand)2019, 65(7):77-83
  • Int J Food Sci Nutr.2019, 70(7):825-833
  • Oxid Med Cell Longev2019, 9056845:13
  • Saudi Pharm J2020, 10.1016
  • ...
  • 生物活性
    Description: Auraptenol possesses robust antidepressant-like efficacy in mice. It has potential to be a novel analgesic for the management of neuropathic pain, it attenuates vincristine-induced mechanical hyperalgesia through serotonin 5-HT1A receptors. Auraptenol shows high inhibitory activities against larval settlement of Balanus albicostatus with EC50values of 3.38 ug m/L.
    Targets: 5-HT Receptor
    In vitro:
    Zhongguo Zhong Yao Za Zhi. 2014 Nov;39(22):4356-9.
    [Coumarins from Leonurus japonicus and their anti-platelet aggregative activity].[Pubmed: 25850267]
    Chemical constituents of Leonurus japonicus were isolated and purified by a combination of various chromatographic techniques including column chromatography over silica gel, Sephadex LH-20, MCI, and Rp C18.
    METHODS AND RESULTS:
    Structures of the isolates were determined by spectroscopic analysis as 10 coumarins: bergapten (1), xanthotoxin (2), isopimpinellin (3), isogosferal (4), imperatorin (5), meransin hydrate(6), isomeranzin(7), murrayone(8) , Auraptenol(9), and osthol(10). In addition to compound 9, the others were isolated from the genus Leonurus for the first time.
    CONCLUSIONS:
    In the in vitro assay, compounds 4 and 8 significantly inhibited the abnormal increase of platelet aggregation induced by ADP.
    Int J Mol Sci. 2013 Jan 9;14(1):1197-206.
    Coumarins from the Herb Cnidium monnieri and Chemically Modified Derivatives as Antifoulants against Balanus albicostatus and Bugula neritina Larvae.[Pubmed: 23303279]

    METHODS AND RESULTS:
    In the search for new environmental friendly antifouling (AF) agents, four coumarins were isolated from the herbal plant Cnidium monnieri, known as osthole (1), imperatorin (2), isopimpinellin (3) and Auraptenol (4). Furthermore, five coumarin derivatives, namely 8-epoxypentylcoumarin (5), meranzin hydrate (6), 2'-deoxymetranzin hydrate (7), 8-methylbutenalcoumarin (8), and micromarin-F (9) were synthesized from osthole. Compounds 1, 2, 4, 7 showed high inhibitory activities against larval settlement of Balanus albicostatus with EC(50) values of 4.64, 3.39, 3.38, 4.67 μg mL-1. Compound 8 could significantly inhibit larval settlement of Bugula neritina with an EC(50) value of 3.87 μg mL-1.
    CONCLUSIONS:
    The impact of functional groups on anti-larval settlement activities suggested that the groups on C-5' and C-2'/C-3' of isoamylene chian could affect the AF activities.
    In vivo:
    Sci Rep. 2013 Nov 29;3:3377.
    Auraptenol attenuates vincristine-induced mechanical hyperalgesia through serotonin 5-HT1A receptors.[Pubmed: 24287473]
    Common chemotherapeutic agents such as vincristine often cause neuropathic pain during cancer treatment in patients. Such neuropathic pain is refractory to common analgesics and represents a challenging clinical issue. Angelicae dahuricae radix is an old traditional Chinese medicine with demonstrated analgesic efficacy in humans. However, the active component(s) that attribute to the analgesic action have not been identified.
    METHODS AND RESULTS:
    This work described the anti-hyperalgesic effect of one coumarin component, Auraptenol, in a mouse model of chemotherapeutic agent vincristine-induced neuropathic pain. We reported that Auraptenol dose-dependently reverted the mechanical hyperalgesia in mice within the dose range of 0.05-0.8 mg/kg. In addition, the anti-hyperalgesic effect of Auraptenol was significantly blocked by a selective serotonin 5-HT1A receptor antagonist WAY100635 (1 mg/kg). Within the dose range studied, Auraptenol did not significantly alter the general locomotor activity in mice.
    CONCLUSIONS:
    Taken together, this study for the first time identified an active component from the herbal medicine angelicae dahuricae radix that possesses robust analgesic efficacy in mice. These data support further studies to assess the potential of Auraptenol as a novel analgesic for the management of neuropathic pain.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.8417 mL 19.2086 mL 38.4172 mL 76.8344 mL 96.043 mL
    5 mM 0.7683 mL 3.8417 mL 7.6834 mL 15.3669 mL 19.2086 mL
    10 mM 0.3842 mL 1.9209 mL 3.8417 mL 7.6834 mL 9.6043 mL
    50 mM 0.0768 mL 0.3842 mL 0.7683 mL 1.5367 mL 1.9209 mL
    100 mM 0.0384 mL 0.1921 mL 0.3842 mL 0.7683 mL 0.9604 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    8-(二甲基烯丙基)-7-羟基-6-甲氧基香豆素; Cedrelopsin CFN89410 19397-28-5 C15H16O4 = 260.28 5mg QQ客服:1148253675
    O-Methylcedrelopsin; O-Methylcedrelopsin CFN92731 72916-61-1 C16H18O4 = 274.3 5mg QQ客服:1413575084
    月橘香豆精; 九里香内酯; Coumurrayin CFN99811 17245-25-9 C16H18O4 = 274.3 5mg QQ客服:1413575084
    (S)-8-[(3,3-二甲基环氧乙烷基)甲基]-5,7-二甲氧基-2H-1-苯并吡喃-2-酮; Sibiricin CFN97531 95188-34-4 C16H18O5 = 290.3 5mg QQ客服:1148253675
    九里香甲素; Isomexoticin CFN97454 88585-86-8 C16H20O6 = 308.3 5mg QQ客服:2159513211
    九里香醇; Murraol CFN99097 109741-38-0 C15H16O4 = 260.3 5mg QQ客服:1413575084
    异味决明内酯醇; Casegravol CFN97693 74474-76-3 C15H16O5 = 276.29 5mg QQ客服:2159513211
    蛇床子素; Osthol CFN98765 484-12-8 C15H16O3 = 244.3 20mg QQ客服:3257982914
    橙皮内酯; Meranzin CFN98249 23971-42-8 C15H16O4 = 260.3 5mg QQ客服:3257982914
    水合蛇床子素; Osthol hydrate CFN90848 69219-24-5 C15H18O4 = 262.3 10mg QQ客服:3257982914

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