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  • 异橙皮内酯

    Isomeranzin

    异橙皮内酯
    产品编号 CFN99090
    CAS编号 1088-17-1
    分子式 = 分子量 C15H16O4 = 260.3
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Coumarins
    植物来源 The peels of Citrus maxima
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    异橙皮内酯 CFN99090 1088-17-1 1mg QQ客服:3257982914
    异橙皮内酯 CFN99090 1088-17-1 5mg QQ客服:3257982914
    异橙皮内酯 CFN99090 1088-17-1 10mg QQ客服:3257982914
    异橙皮内酯 CFN99090 1088-17-1 20mg QQ客服:3257982914
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Martin Luther University of Halle-Wittenberg (Germany)
  • University of Indonesia (Indonesia)
  • University of South Australia (Australia)
  • University of Limpopo (South Africa)
  • University of Wisconsin-Madison (USA)
  • University of Toulouse (France)
  • Anna University (India)
  • Korea Intitute of Science and Technology (KIST) (Korea)
  • Medical University of South Carolina (USA)
  • Universite de Lille1 (France)
  • Kyung Hee University (Korea)
  • Utah State University (USA)
  • Srinakharinwirot University (Thailand)
  • Biotech R&D Institute (USA)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Nat Prod Sci.2014, 20(3):182-190
  • J Breast Cancer.2015, 18(2):112-118
  • Korean Herb. Med. Inf. 2016, 4(1):35-42
  • Int J Mol Sci.2017, 18(12)
  • J Ethnopharmacol.2017, 198:91-97
  • Int J Anal Chem.2017, 2017:1254721
  • Journal of Functional Foods2017, 30:30-38
  • Front Pharmacol.2017, 8:205
  • Food Res Int.2017, 96:40-45
  • Pharmacognosy Magazine2018, 14(56):418-424
  • Evid Based Complement Alternat Med.2018, 2018:8565132
  • Biol Pharm Bull.2018, 41(11):1645-1651
  • Mol Cells.2018, 41(8):771-780
  • Eur J Pharmacol.2018, 832:96-103
  • J Cancer.2019, 10(23):5843-5851
  • Molecules.2019, 24(1):E159
  • Phytother Res.2019, 33(4):1104-1113
  • Plos One.2019, 15(2):e0220084
  • Metabolites.2019, 9(11):E271
  • Biomedicine & Pharmacotherapy2020, 125:109950
  • Drug Des Devel Ther.2020, 14:61-71
  • J Ethnopharmacol.2020, 249:112381
  • Journal of Chromatography A2020, 460942
  • ...
  • 生物活性
    Description: Isomeranzin has anti-inflammatory activity, it suppresses inflammation by inhibiting M1 macrophage polarization through the p65, NF-κB and ERK pathway.
    Targets: NF-kB | ERK
    In vivo:
    Int Immunopharmacol. 2016 Sep;38:175-85.
    Isomeranzin suppresses inflammation by inhibiting M1 macrophage polarization through the NF-κB and ERK pathway.[Pubmed: 27285671 ]
    Macrophage polarization plays an important role in inflammation. Regulation of the polarization has been reported to be effective therapeutics for various kinds of inflammatory diseases. The aims of the present study were to investigate the anti-inflammatory property of isomeranzin isolating from Murraya exotica as well as potential molecular mechanisms.
    METHODS AND RESULTS:
    Results showed that isomeranzin specifically reduced the M1 macrophage-associated pro-inflammatory cytokines through down-regulation of NF-κB and ERK signals. Immunoprecipitation and RNA silencing indicated suppression of isomeranzin in NF-κB activation was relying on the decreasing of TRAF6 ubiquitination. In vivo studies showed isomeranzin evidently inhibited LPS-induced sepsis for rising survival rate, improving tissue damage and lessening inflammatory cytokines. In accordance with in vitro studies, isomeranzin significantly blocked expression of p-p65 and p-ERK in lung and liver tissues. Moreover, isomeranzin ameliorated DSS and TNBS-induced colitis due to its anti-inflammatory effects.
    CONCLUSIONS:
    Taken together, isomeranzin suppressed inflammatory diseases by controlling M1 macrophage polarization through the NF-κB and ERK pathway.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.8417 mL 19.2086 mL 38.4172 mL 76.8344 mL 96.043 mL
    5 mM 0.7683 mL 3.8417 mL 7.6834 mL 15.3669 mL 19.2086 mL
    10 mM 0.3842 mL 1.9209 mL 3.8417 mL 7.6834 mL 9.6043 mL
    50 mM 0.0768 mL 0.3842 mL 0.7683 mL 1.5367 mL 1.9209 mL
    100 mM 0.0384 mL 0.1921 mL 0.3842 mL 0.7683 mL 0.9604 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    3'-O-Methylmurraol; 3'-O-Methylmurraol CFN89183 1891097-17-8 C16H18O4 = 274.31 5mg QQ客服:2932563308
    酸橙素烯醇; Auraptenol CFN99340 1221-43-8 C15H16O4 = 260.3 5mg QQ客服:1148253675
    九里香酮; Murrayone CFN98505 19668-69-0 C15H14O4 = 258.27 10mg QQ客服:215959384
    异橙皮内酯 ; Isomeranzin CFN99090 1088-17-1 C15H16O4 = 260.3 10mg QQ客服:3257982914
    橙皮内酯水合物; Meranzin hydrate CFN98994 5875-49-0 C15H18O5 = 278.3 5mg QQ客服:1413575084
    (S)-8-(3-乙氧基-2-羟基-3-甲基丁基)-7-甲氧基-2H-1-苯并吡喃-2-酮; 8-(3-Ethoxy-2-hydroxy-3-methylbutyl)-7-methoxycoumarin CFN99362 125072-68-6 C17H22O5 = 306.4 5mg QQ客服:1413575084
    8-(二甲基烯丙基)-7-羟基-6-甲氧基香豆素; Cedrelopsin CFN89410 19397-28-5 C15H16O4 = 260.28 5mg QQ客服:1413575084
    O-Methylcedrelopsin; O-Methylcedrelopsin CFN92731 72916-61-1 C16H18O4 = 274.3 5mg QQ客服:2159513211
    月橘香豆精; 九里香内酯; Coumurrayin CFN99811 17245-25-9 C16H18O4 = 274.3 5mg QQ客服:2159513211
    (S)-8-[(3,3-二甲基环氧乙烷基)甲基]-5,7-二甲氧基-2H-1-苯并吡喃-2-酮; Sibiricin CFN97531 95188-34-4 C16H18O5 = 290.3 5mg QQ客服:2159513211

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