• 中药标准品生产商,产品定制服务
  • 橙皮内酯水合物

    Meranzin hydrate

    橙皮内酯水合物
    产品编号 CFN98994
    CAS编号 5875-49-0
    分子式 = 分子量 C15H18O5 = 278.3
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Coumarins
    植物来源 The roots of Angelica biserrata
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    橙皮内酯水合物 CFN98994 5875-49-0 1mg QQ客服:2932563308
    橙皮内酯水合物 CFN98994 5875-49-0 5mg QQ客服:2932563308
    橙皮内酯水合物 CFN98994 5875-49-0 10mg QQ客服:2932563308
    橙皮内酯水合物 CFN98994 5875-49-0 20mg QQ客服:2932563308
    存储与注意事项
    1. 在您收到产品后请检查产品。如无问题,请将产品存入冰霜并且样品瓶保持密封,产品可以存放长达24个月(2-8摄氏度)。

    2. 只要有可能,产品溶解后,您应该在同一天应用于您的实验。 但是,如果您需要提前做预实验,或者需要全部溶解,我们建议您将溶液以等分试样的形式存放在-20℃的密封小瓶中。 通常,这些可用于长达两周。 使用前,打开样品瓶前,我们建议您将产品平衡至室温至少1小时。

    3. 需要更多关于溶解度,使用和处理的建议? 请发送电子邮件至:service@chemfaces.com
    订购流程
  • 1. 在线订购
  • 请联系我们QQ客服

  • 2. 电话订购
  • 请拨打电话:
    027-84237683 或 027-84237783

  • 3. 邮件或传真订购
  • 发送电子邮件到: manager@chemfaces.com 或
    发送传真到:027-84254680

  • 提供订购信息
  • 为了方便客户的订购,请需要订购ChemFaces产品的客户,在下单的时候请提供下列信息,以供我们快速为您建立发货信息。
  •  
  • 1. 产品编号(CAS No.或产品名称)
  • 2. 发货地址
  • 3. 联系方法 (联系人,电话)
  • 4. 开票抬头 (如果需要发票的客户)
  • 5. 发票地址(发货地址与发票地址不同)
  • 发货时间
    1. 付款方式为100%预付款客户,我们将在确认收到货款后当天或1-3个工作日发货。

    2. 付款方式为月结的客户,我们承诺在收到订单后当天或1-3个工作日内发货。

    3. 如果客户所需要的产品,需要重新生产,我们有权告知客户,交货时间需要延期。
    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Korea Food Research Institute(KFRI) (Korea)
  • Complutense University of Madrid (Spain)
  • Fraunhofer-Institut für Molekularbiologie und Angewandte ?kologie IME (Germany)
  • Tokyo Woman's Christian University (Japan)
  • Griffith University (Australia)
  • Northeast Normal University Changchun (China)
  • University of South Australia (Australia)
  • University of Padjajaran (Indonesia)
  • Universiti Sains Malaysia (Malaysia)
  • Vin?a Institute of Nuclear Sciences (Serbia)
  • Kamphaengphet Rajabhat University (Thailand)
  • University of Otago (New Zealand)
  • Instytut Nawozów Sztucznych w Pu?awach (Poland)
  • University of Malaya (Malaysia)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • J. of Agricultural Science2015, 1916-9760
  • Mediators Inflamm.2016, 2016:7216912
  • Molecules.2016, 21(6)
  • Biomed Chromatogr.2016, 30(10):1573-81
  • PLoS One.2017, 12(3):e0173585
  • Cytotechnology.2017, 69(5):765-773
  • Sci Rep.2017, 7:467-479
  • Arch Toxicol.2017, 91(10):3225-3245
  • Industrial Crops and Products2017, 95:286-295
  • Front Aging Neurosci.2018, 10:269
  • Industrial Crops and Products2018, 353-362
  • Biol Pharm Bull.2018, 41(1):65-72
  • Food and Fermentation Industries2018, 44(371)
  • Front Pharmacol.2018, 9:236
  • Nat Commun.2019, 10(1):5169
  • J Chromatogr B Analyt Technol Biomed Life Sci.2019, 1124:323-330
  • APMIS.2019, 127(10):688-695
  • Molecules.2019, 24(4):E744
  • Food Chem.2019, 274:345-350
  • J Enzyme Inhib Med Chem.2019, 34(1):134-143
  • Phytomedicine.2019, 59:152785
  • Int Immunopharmacol.2019, 71:361-371
  • Molecules.2020, 25(3):734
  • ...
  • 生物活性
    Description: Meranzin hydrate exhibits antidepressive and prokinetic-like effects through the regulation of the common mediator, the alpha 2-adrenoceptor , and α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors; it produces a rapid effect mediated by AMPA receptors and involving BDNF modulation through the ERK1/2 pathway.Meranzin hydrate can induce similar effect to Fructus Aurantii on intestinal motility and it was, at least in part, mediated by stimulation of H1 histamine receptors.
    Targets: Adrenergic Receptor | ERK | AMPA receptors
    In vivo:
    J Ethnopharmacol. 2011 Sep 1;137(1):205-13.
    Pharmacokinetic study of the prokinetic compounds meranzin hydrate and ferulic acid following oral administration of Chaihu-Shugan-San to patients with functional dyspepsia.[Pubmed: 21605652]
    The prokinetic activity of ferulic acid derived from Ligusticum chuanxiong hort in the Chaihu-Shugan-San formula has been shown to be similar to Chaihu-Shugan-San, a popular traditional Chinese medicine for treating functional dyspepsia. The effects of Meranzin hydrate, a compound isolated from Fructus aurantii in the Chaihu-Shugan-San formula, are unclear, as the pharmacokinetics have never been studied in patients with functional dyspepsia. This study aimed to describe the pharmacokinetics of ferulic acid and merazin hydrate by evaluating the prokinetics induced by Chaihu-Shugan-San and Meranzin hydrate.
    METHODS AND RESULTS:
    Gastric emptying and intestinal transit were measured after oral administration of a single dose of Chaihu-Shugan-San or Meranzin hydrate in rats. The tone of rat ileum was selected as direct evidence of the prokinetic activity of Meranzin hydrate. Patients with functional dyspepsia were recruited, and Meranzin hydrate and ferulic acid were identified by ultra performance liquid chromatography with tandem mass spectrometry in the plasma of patients following a single oral administration of Chaihu-Shugan-San. The resulting pharmacokinetic properties were determined by ultra performance liquid chromatography coupled to photo diode array. RESULTS: In rats, single doses of Chaihu-Shugan-San (20 g/kg) and Meranzin hydrate (28 mg/kg) significantly accelerated gastric emptying and intestinal transit (Chaihu-Shugan-San: 68.9 ± 5.6% and 72.3 ± 4.7%, Meranzin hydrate: 72.9 ± 3.8% and 75.2 ± 3.1%) compared with the control (55.45 ± 3.7% and 63.51 ± 5.1%, P<0.05), showing similar results as cisapride (69.6 ± 4.8% and 71.6 ± 6.3%). Meranzin hydrate (30, 100 μmol/L) directly increased the amplitude of rat ileum compared with the control (P<0.01). The pharmacokinetics profiles of Meranzin hydrate and ferulic acid in patient plasma was fitted with a two-compartment model detected by a simple, rapid and accurate UPLC method. Time to reach peak concentration of Meranzin hydrate (0.371 mg/L) and ferulic acid (0.199 mg/L) was 23.57 min and 27.50 min, respectively. The elimination half-life and area under the concentration-time curve from t=0 to the last time of Meranzin hydrate and ferulic acid were 139.53 min and 31.445 μg min/mL and 131.27 min and 14.835 μg min/mL, respectively. The absorption constant and volume of distribution of Meranzin hydrate and ferulic acid were 0.185 ± 0.065 min(-1) and 3782.89 ± 2686.72 L/kg and 0.524 ± 0.157 min(-1) and 11713 ± 7618.68 L/kg, respectively. The experimental results of the pharmacokinetic parameters of Meranzin hydrate and ferulic acid indicate that they were absorbed and distributed rapidly.
    CONCLUSIONS:
    The pharmacodynamics and pharmacokinetics of prokinetic Chaihu-Shugan-San and its compounds are useful for monitoring Chaihu-Shugan-San formulas in clinical practice and for understanding therapeutic mechanisms.
    Exp Ther Med. 2013 Oct;6(4):913-918.
    Comparison between the pharmacokinetics of meranzin hydrate in a rat model of chronic depression and in controls following the oral administration of Chaihu-Shugan-San.[Pubmed: 24137289]
    Previous studies have shown that Meranzin hydrate (MH) may be beneficial in depressive disorders. However, to the best of our knowledge, the pharmacokinetic characteristics of MH in depression have not previously been investigated. Chronic mild stress (CMS) in rats is used as a model of depression. The present study was designed to evaluate and compare the pharmacokinetics of MH in CMS and control rats following the oral administration of Chaihu-Shugan-San (CSS).
    METHODS AND RESULTS:
    Rats were randomly divided into CMS and control groups and blood samples were obtained following the oral administration of CSS. The quantification of Meranzin hydrate levels in the plasma for pharmacokinetic study was achieved using a simple and rapid ultra-performance liquid chromatography with photodiode array (UPLC-PDA) method. Following the oral administration of CSS to CMS rats and controls, the maximum plasma concentration (Cmax) of Meranzin hydrate was 58.66±6.64 and 57.54±12.67 ng/ml at 108.00±26.83 and 54.00±8.22 min, respectively. Compared with the value of the area under the concentration-time curve (AUC)0-1440 in control rats (19,896.76±1,041.95 μg·min/l), the AUC0-1440 value was reduced in CMS rats (18,401.32±4332.65 μg·min/l). There were no significant differences in the majority of the pharmacokinetic parameters of Meranzin hydrate, including the values for Cmax, AUC0-1440, clearance rate (CL/F) and mean residence time (MRT0-1440), between the CMS rats and the controls.
    CONCLUSIONS:
    However, the pharmacokinetic parameters showed that CMS accelerated the absorption of Meranzin hydrate in rats following the oral administration of CSS.
    Amino Acids. 2013 Feb;44(2):413-22.
    The involvement of AMPA-ERK1/2-BDNF pathway in the mechanism of new antidepressant action of prokinetic meranzin hydrate.[Pubmed: 22782214]
    It was recently discovered that ketamine can relieve depression in a matter of hours through an action on α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors. This is much more rapid than the several weeks required for the available antidepressants to show therapeutic efficacy. However, ketamine has negative side effects. The aim of this study was to determine whether the natural prokinetic drug Meranzin hydrate (MH) has a fast-acting antidepressant effect mediated by AMPA receptors.
    METHODS AND RESULTS:
    By means of in vivo and in vitro experiments, we found that (1) treatment of rats with Meranzin hydrate at 9 mg/kg decreased immobility time in a forced swimming test (FST), as did the popular antidepressant fluoxetine and the AMPA receptor positive modulator aniracetam. Pretreatment of rats with NBQX (10 mg/kg), an antagonist of AMPA receptors, blocked this effect of Meranzin hydrate. (2) Meranzin hydrate increased number of crossings of forced swimming rats in the open field test. (3) FST enhanced hippocampal ERK1/2, p-ERK1/2 and BDNF expression levels. Meranzin hydrate (9 mg/kg) treatment further up-regulated hippocampal p-ERK1/2 and BDNF expression levels, and this effect was prevented by NBQX. (4) Meranzin hydrate-increased BDNF expression corresponded with MH-decreased immobility time in the FST. (5) In vitro experiments, we found that incubation of rats hippocampus slices with Meranzin hydrate (10, 20 μM respectively) increased concentrations of BDNF and p-ERK1/2. This effect of MH (20 μM) were prevented by NBQX.
    CONCLUSIONS:
    In conclusion, in animals subjected to acute stress, the natural prokinetic drug Meranzin hydrate produced a rapid effect mediated by AMPA receptors and involving BDNF modulation through the ERK1/2 pathway.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.5932 mL 17.9662 mL 35.9324 mL 71.8649 mL 89.8311 mL
    5 mM 0.7186 mL 3.5932 mL 7.1865 mL 14.373 mL 17.9662 mL
    10 mM 0.3593 mL 1.7966 mL 3.5932 mL 7.1865 mL 8.9831 mL
    50 mM 0.0719 mL 0.3593 mL 0.7186 mL 1.4373 mL 1.7966 mL
    100 mM 0.0359 mL 0.1797 mL 0.3593 mL 0.7186 mL 0.8983 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    橙皮内酯; Meranzin CFN98249 23971-42-8 C15H16O4 = 260.3 5mg QQ客服:1413575084
    水合蛇床子素; Osthol hydrate CFN90848 69219-24-5 C15H18O4 = 262.3 10mg QQ客服:1148253675
    3'-O-Methylmurraol; 3'-O-Methylmurraol CFN89183 1891097-17-8 C16H18O4 = 274.31 5mg QQ客服:1148253675
    酸橙素烯醇; Auraptenol CFN99340 1221-43-8 C15H16O4 = 260.3 5mg QQ客服:2159513211
    九里香酮; Murrayone CFN98505 19668-69-0 C15H14O4 = 258.27 10mg QQ客服:2932563308
    异橙皮内酯 ; Isomeranzin CFN99090 1088-17-1 C15H16O4 = 260.3 10mg QQ客服:215959384
    橙皮内酯水合物; Meranzin hydrate CFN98994 5875-49-0 C15H18O5 = 278.3 5mg QQ客服:2932563308
    (S)-8-(3-乙氧基-2-羟基-3-甲基丁基)-7-甲氧基-2H-1-苯并吡喃-2-酮; 8-(3-Ethoxy-2-hydroxy-3-methylbutyl)-7-methoxycoumarin CFN99362 125072-68-6 C17H22O5 = 306.4 5mg QQ客服:3257982914
    8-(二甲基烯丙基)-7-羟基-6-甲氧基香豆素; Cedrelopsin CFN89410 19397-28-5 C15H16O4 = 260.28 5mg QQ客服:1148253675
    O-Methylcedrelopsin; O-Methylcedrelopsin CFN92731 72916-61-1 C16H18O4 = 274.3 5mg QQ客服:2932563308

    信息支持


    公司简介
    订购流程
    付款方式
    退换货政策

    ChemFaces提供的产品仅用于科学研究使用,不用于诊断或治疗程序。

    联系方式


    电机:027-84237783
    传真:027-84254680
    在线QQ: 215959384
    E-Mail:manager@chemfaces.com

    湖北省武汉沌口经济技术开区车城南路83号1号楼第三层厂房


    ChemFaces为科学家,科研人员与企业提供快速的产品递送。我们通过瑞士SGS ISO 9001:2008质量体系认证天然化合物与对照品的研发和生产