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  • 橙皮内酯

    Meranzin

    橙皮内酯
    产品编号 CFN98249
    CAS编号 23971-42-8
    分子式 = 分子量 C15H16O4 = 260.3
    产品纯度 >=98%
    物理属性 Cryst.
    化合物类型 Coumarins
    植物来源 The peels of Citrus maxima
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    橙皮内酯 CFN98249 23971-42-8 1mg QQ客服:1413575084
    橙皮内酯 CFN98249 23971-42-8 5mg QQ客服:1413575084
    橙皮内酯 CFN98249 23971-42-8 10mg QQ客服:1413575084
    橙皮内酯 CFN98249 23971-42-8 20mg QQ客服:1413575084
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of Vigo (Spain)
  • Nanjing University of Chinese Medicine (China)
  • University of the Basque Country (Spain)
  • VIT University (India)
  • University of South Australia (Australia)
  • University of Pretoria (South Africa)
  • Universiti Sains Malaysia (Malaysia)
  • Auburn University (USA)
  • The Institute of Cancer Research (United Kingdom)
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  • Universiti Malaysia Pahang (Malaysia)
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  • Instituto Politécnico de Bragan?a (Portugal)
  • Universidad de Buenos Aires (Argentina)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • SBRAS2016, 12
  • Asian J Beauty Cosmetol2016, 14(3):249-257
  • Anal Bioanal Chem. 2016, 408(15)
  • J Pharm Anal.2016, 6(6):363-373
  • Current Pharmaceutical Analysis2017, 13(5)
  • Research on Crops.2017, 18(3):569
  • JPC-Journal of Planar Chromatography 2017, 30(4)
  • Drug Test Anal.2018, 10(10):1579-1589
  • Int J Biol Macromol.2018, 112:1093-1103
  • Fitoterapia.2018, 124:92-102
  • Life Sci.2018, 209:498-506
  • Molecules.2018, 23(11):E2837
  • Curr Eye Res.2018, 43(1):27-34
  • Food and Fermentation Industries2018, 44(371)
  • Korean J Dent Mater.2018, 45(2):139-146
  • Nutrients.2019, 11(4):E936
  • Front Neurosci.2019, 13:1091
  • J Pharm Biomed Anal.2019, 164:119-127
  • Molecules.2019, 24(20):3755
  • Chin J Appl. Physiol.2019, 35(3):283-288
  • J Food Sci Technol.2019, 56(5):2712-2720
  • Planta Med.2019, 85(9-10):766-773
  • Saudi Pharm J2020, 10.1016
  • ...
  • 生物活性
    Description: Meranzin exhibits strong anti-inflammatory and analgesic activity. Meranzin hydrate can induce similar effect to Fructus Aurantii on intestinal motility and it was, at least in part, mediated by stimulation of H1 histamine receptors.
    Targets: Immunology & Inflammation related
    In vivo:
    J Ethnopharmacol. 2011 Sep 1;137(1):205-13.
    Pharmacokinetic study of the prokinetic compounds meranzin hydrate and ferulic acid following oral administration of Chaihu-Shugan-San to patients with functional dyspepsia.[Pubmed: 21605652]
    The effects of Meranzin hydrate, a compound isolated from Fructus aurantii in the Chaihu-Shugan-San formula, are unclear, as the pharmacokinetics have never been studied in patients with functional dyspepsia. This study aimed to describe the pharmacokinetics of ferulic acid and merazin hydrate by evaluating the prokinetics induced by Chaihu-Shugan-San and Meranzin hydrate.
    METHODS AND RESULTS:
    Gastric emptying and intestinal transit were measured after oral administration of a single dose of Chaihu-Shugan-San or Meranzin hydrate in rats. The tone of rat ileum was selected as direct evidence of the prokinetic activity of Meranzin hydrate. Patients with functional dyspepsia were recruited, and Meranzin hydrate and ferulic acid were identified by ultra performance liquid chromatography with tandem mass spectrometry in the plasma of patients following a single oral administration of Chaihu-Shugan-San. The resulting pharmacokinetic properties were determined by ultra performance liquid chromatography coupled to photo diode array.In rats, single doses of Chaihu-Shugan-San (20 g/kg) and Meranzin hydrate (28 mg/kg) significantly accelerated gastric emptying and intestinal transit (Chaihu-Shugan-San: 68.9 ± 5.6% and 72.3 ± 4.7%, Meranzin hydrate: 72.9 ± 3.8% and 75.2 ± 3.1%) compared with the control (55.45 ± 3.7% and 63.51 ± 5.1%, P<0.05), showing similar results as cisapride (69.6 ± 4.8% and 71.6 ± 6.3%). Meranzin hydrate (30, 100 μmol/L) directly increased the amplitude of rat ileum compared with the control (P<0.01). The pharmacokinetics profiles of Meranzin hydrate and ferulic acid in patient plasma was fitted with a two-compartment model detected by a simple, rapid and accurate UPLC method. Time to reach peak concentration of Meranzin hydrate (0.371 mg/L) and ferulic acid (0.199 mg/L) was 23.57 min and 27.50 min, respectively. The elimination half-life and area under the concentration-time curve from t=0 to the last time of Meranzin hydrate and ferulic acid were 139.53 min and 31.445 μg min/mL and 131.27 min and 14.835 μg min/mL, respectively. The absorption constant and volume of distribution of Meranzin hydrate and ferulic acid were 0.185 ± 0.065 min(-1) and 3782.89 ± 2686.72 L/kg and 0.524 ± 0.157 min(-1) and 11713 ± 7618.68 L/kg, respectively. The experimental results of the pharmacokinetic parameters of Meranzin hydrate and ferulic acid indicate that they were absorbed and distributed rapidly.
    CONCLUSIONS:
    The pharmacodynamics and pharmacokinetics of prokinetic Chaihu-Shugan-San and its compounds are useful for monitoring Chaihu-Shugan-San formulas in clinical practice and for understanding therapeutic mechanisms.
    Chinese Journal of Spectroscopy Laboratory,2011,28(6):2999- 3003.
    Anti-Inflammation and Analgesic Activities of Coumarins Compounds from the Leaves of Murraya Exotica(L.)[Reference: WebLink]

    METHODS AND RESULTS:
    The coumarins compounds that possed anti-inflammation and analgesic acitivities were separated from Murraya exotica(L.).Using mice writhing test as animal model of activity trace,silica gel chromatographic column as separation means,spectroscopy as the ways to determine the structures,and mice writhing test and xylene-induced ear edema test were employed to determine the anti-inflammation and analgesic activities.Six coumarins compounds were obtained.They were osthole,phebalosin,Meranzin,umbelliferone,scopoletin,and murracarpin.
    CONCLUSIONS:
    Murracarpin exhibited strong anti-inflammatory and analgesic activity,which possibly related to its structure including a methoxy group at C-7,a short chain at C-8 which contained both double-bond and hydroxyl groups.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.8417 mL 19.2086 mL 38.4172 mL 76.8344 mL 96.043 mL
    5 mM 0.7683 mL 3.8417 mL 7.6834 mL 15.3669 mL 19.2086 mL
    10 mM 0.3842 mL 1.9209 mL 3.8417 mL 7.6834 mL 9.6043 mL
    50 mM 0.0768 mL 0.3842 mL 0.7683 mL 1.5367 mL 1.9209 mL
    100 mM 0.0384 mL 0.1921 mL 0.3842 mL 0.7683 mL 0.9604 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    九里香醇; Murraol CFN99097 109741-38-0 C15H16O4 = 260.3 5mg QQ客服:2932563308
    异味决明内酯醇; Casegravol CFN97693 74474-76-3 C15H16O5 = 276.29 5mg QQ客服:1413575084
    蛇床子素; Osthol CFN98765 484-12-8 C15H16O3 = 244.3 20mg QQ客服:2159513211
    橙皮内酯; Meranzin CFN98249 23971-42-8 C15H16O4 = 260.3 5mg QQ客服:2159513211
    水合蛇床子素; Osthol hydrate CFN90848 69219-24-5 C15H18O4 = 262.3 10mg QQ客服:3257982914
    3'-O-Methylmurraol; 3'-O-Methylmurraol CFN89183 1891097-17-8 C16H18O4 = 274.31 5mg QQ客服:2932563308
    酸橙素烯醇; Auraptenol CFN99340 1221-43-8 C15H16O4 = 260.3 5mg QQ客服:1148253675
    九里香酮; Murrayone CFN98505 19668-69-0 C15H14O4 = 258.27 10mg QQ客服:215959384
    异橙皮内酯 ; Isomeranzin CFN99090 1088-17-1 C15H16O4 = 260.3 10mg QQ客服:215959384
    橙皮内酯水合物; Meranzin hydrate CFN98994 5875-49-0 C15H18O5 = 278.3 5mg QQ客服:3257982914

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