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  • 蛇床子素

    Osthol

    蛇床子素
    产品编号 CFN98765
    CAS编号 484-12-8
    分子式 = 分子量 C15H16O3 = 244.3
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Coumarins
    植物来源 The fructus of Cnidium monnieri (L.) Cusson
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
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    产品名称 产品编号 CAS编号 包装 QQ客服
    蛇床子素 CFN98765 484-12-8 10mg QQ客服:1413575084
    蛇床子素 CFN98765 484-12-8 20mg QQ客服:1413575084
    蛇床子素 CFN98765 484-12-8 50mg QQ客服:1413575084
    蛇床子素 CFN98765 484-12-8 100mg QQ客服:1413575084
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Institute of Chinese Materia Medica (China)
  • St. Jude Children Research Hospital (USA)
  • Guangzhou Institutes of Biomedicine and Health (China)
  • University of British Columbia (Canada)
  • National Cancer Institute (USA)
  • Ateneo de Manila University (Philippines)
  • Florida A&M University (USA)
  • University of Fribourg (Switzerland)
  • Universiti Kebangsaan Malaysia (Malaysia)
  • Stanford University (USA)
  • University of Eastern Finland (Finland)
  • The Australian National University (Australia)
  • Instytut Nawozów Sztucznych w Pu?awach (Poland)
  • Rio de Janeiro State University (Brazil)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Scientific World Journal.2014, 2014:654193
  • BMC Complement Altern Med.2016, 16:213
  • Oncol Rep.2016, 35(3):1356-64
  • J Agric Food Chem.2016, 64(35):6783-90
  • Universidade Estadual Paulista2017, 11449
  • African J. Agricultural Research 2017, 12(13):1164-1168
  • Int. J. of Food Properties2017, S108-S118
  • Nutrients.2018, 10(12)
  • Nutrients.2018, 10(12):E1998
  • J Chromatogr B Analyt Technol Biomed Life Sci.2018, 1080:27-36
  • Neurochem Int.2018, 121:114-124
  • Mol Pharm.2018, 15(8):3285-3296
  • J Ethnopharmacol.2018, 210:88-94
  • Industrial Crops and Products2018, 353-362
  • Front Pharmacol.2018, 9:236
  • J Mol Med (Berl).2018, 96(7):661-672
  • Front Pharmacol.2019, 10:1025
  • Biomed Pharmacother.2019, 111:262-269
  • Front Neurosci.2019, 13:1091
  • Srinagarind Medical Journal2019, 34(1)
  • Int J Cosmet Sci.2019, 41(1):12-20
  • Phytomedicine.2019, 67:153159
  • Molecules.2020, 25(3):734
  • ...
  • 生物活性
    Description: Osthol is a natural antihistamine alternative, may be a potential inhibitor of histamine H1 receptor activity. Osthol has toxicity, may be used as bio-pesticides. Osthol is an inhibitor of human Pgp and multidrug efflux pumps of Staphylococcus aureus , reversing the resistance against frontline antibacterial drugs.Osthol has anti-allergic, antiosteoporosis, anti-fatty liver, antitumor, and cardioprotective effects. Osthol inhibits hepatic SREBP-1c/2 mRNA expressions and subsequent modulation of SREBP-1c/2-mediated target genes such as FAS, CYP7A and LDL receptor; it can stimulate the osteoblastic differentiation of rat calvarial osteoblast cultures by the BMP-2/p38MAPK/Runx-2/osterix pathway.
    Targets: PPAR | LDL | P450 (e.g. CYP17) | P-gp | p38MAPK | FAS | BMP-2 | Runx-2 | Histamine H1 receptor
    In vitro:
    Environ Health Toxicol. 2014 Dec 10;29:e2014020.
    Acute toxicity assessment of Osthol content in bio-pesticides using two aquatic organisms.[Pubmed: 25518842]
    This study focused on the assessment of acute toxicity caused by Osthol, a major component of environment-friendly biological pesticides, by using two aquatic organisms.
    METHODS AND RESULTS:
    The assessment of acute toxicity caused by Osthol was conducted in Daphnia magna and by examining the morphological abnormalities in Danio rerio embryos. The median effective concentration value of Osthol in D. magna 48 hours after inoculation was 19.3 μM. The median lethal concentration of D. rerio embryo at 96 hours was 30.6 μM. No observed effect concentration and predicted no effect concentration values of Osthol in D. magna and D. rerio were calculated as 5.4 and 0.19 μM, respectively. There was an increase in the morphological abnormalities in D. rerio embryo due to Osthol over time. Coagulation, delayed hatching, yolk sac edema, pericardial edema, and pigmentation were observed in embryos at 24-48 hours. Symptoms of scoliosis and head edema occurred after 72 hours. In addition, bent tails, ocular defects, and symptoms of collapse were observed in fertilized embryo tissue within 96 hours. Ocular defects and pigmentation were the additional symptoms observed in this study.
    CONCLUSIONS:
    Because Osthol showed considerable toxicity levels continuous toxicity evaluation in agro-ecosystems is necessary when bio-pesticides containing Osthol are used.
    Phytother Res. 2007 Mar;21(3):226-30.
    Antitumor effects of Osthol from Cnidium monnieri: an in vitro and in vivo study.[Pubmed: 17154232 ]
    Cnidium monnieri (L.) Cusson is a Chinese medicine which is used widely by traditional medicine doctors. Osthol is a major bio-activity compound of the herb.
    METHODS AND RESULTS:
    In this study, osthol was isolated from C. monnieri and its in vitro and in vivo antitumor effects studied. The results of the in vitro study showed: that osthol inhibited the growth of HeLa, in a time- and concentration-dependent manner, with IC(50) values of 77.96 and 64.94 microm for 24 and 48 h, respectively; that osthol had lower cytotoxic effects in primary cultured normal cervical fibroblasts; and that increased DNA fragmentation and activated PARP in HeLa after treatment with osthol which could induce apoptosis. The results of the in vivo model showed that the survival days of the P-388 D1 tumor-bearing CDF(1) mice were prolonged (ILS% = 37) after osthol (30 mg/kg) was given once a day for 9 days.
    CONCLUSIONS:
    Based on these results, it is suggested that osthol could inhibit P-388 D1 cells in vivo and induce apoptosis in HeLa cells in vitro, and that osthol is good lead compound for developing antitumor drugs. However, C. formosanum Yabe of Taiwan's endemic plants contained little osthol, with no imperatorin, and its major components were different from that of C. monnieri. Therefore, it is suggested that C. formosanum also may possess economic worth.
    In vivo:
    World J Gastroenterol. 2014 Sep 7;20(33):11753-61.
    Osthol attenuates hepatic steatosis via decreased triglyceride synthesis not by insulin resistance.[Pubmed: 25206279]
    To evaluate the effects of osthol on intrahepatic fat synthesis, β-oxidation, inflammation, and insulin resistance by multifaceted analysis.
    METHODS AND RESULTS:
    Sprague-Dawley rats (n = 30) were randomly divided into control, non-alcoholic fatty liver disease (NAFLD), and osthol groups. NAFLD and osthol groups were fed with a high-fat diet for 14 wk. After 8 wk of the high-fat diet, the osthol group also received osthol 20 mg/kg orally 5 times/wk. To assess the insulin resistance, oral glucose tolerance was performed at the end of 14 wk. Immunohistochemical (4-HNE, F4/80) and hematoxylin and eosin (HE) staining were performed on liver tissue extracts after animal sacrifice at 14 wk. SREBP1c, FAS, SCD-1, PPAR-α, CROT, MCP-1, IRS-1, and IRS-2 mRNA expressions were assessed with reverse transcription-polymerase chain reaction. HE staining revealed that, compared with the NAFLD group, the osthol group showed significantly decreased intrahepatic fat content (39.4% vs 21.0%; P = 0.021). SREBP1c expression in the NAFLD group increased compared to controls (P = 0.0001), while osthol treatment decreased SREBP1c expression compared with the NAFLD group (P = 0.0059). In the osthol group, intrahepatic FAS and SCD-1, which act downstream of SREBP1c, decreased significantly compared with the NAFLD group. Moreover, PPAR-α expression in the osthol group was also significantly higher than in the NAFLD group (P = 0.0147).
    CONCLUSIONS:
    Osthol treatment attenuated liver steatosis by decreasing de novo liver triglyceride synthesis and had nominal effects on insulin resistance and liver inflammation.
    Lipids. 2012 Oct;47(10):987-94.
    Reduction of rat cardiac hypertrophy by osthol is related to regulation of cardiac oxidative stress and lipid metabolism.[Pubmed: 22918576]
    The objective of this study was to examine the therapeutic effect of osthol, a coumarin compound isolated from the fruit of Cnidium monnieri (L.) Cusson, on cardiac hypertrophy in rats and investigate its potential mechanisms.
    CONCLUSIONS:
    The rats with cardiac hypertrophy induced by renovascular hypertension were given osthol orally by gavage for 4 weeks. The results showed that in the osthol 20 mg/kg group, the blood pressure, heart weight index and myocardial malondialdehyde content were lowered (p < 0.001, p = 0.002 and p = 0.025, respectively), the myocardial superoxide dismutase and glutathione peroxidase contents were increased (p < 0.001), and the elevated unesterified fatty acids and triacylglycerols in myocardial tissues were decreased (p = 0.017 and p = 0.004, respectively). At the same time, the myocardial peroxisome proliferator-activated receptor (PPAR)-α and carnitine palmitoyltransferase (CPT)-1a mRNA expressions were increased and the myocardial diacylglycerol acyltransferase (DGAT) mRNA expression was decreased in the osthol 20 mg/kg group (p < 0.001). Osthol treatment was associated with a decreased cross-sectional area of cardiomyocytes (p < 0.001).
    CONCLUSIONS:
    These findings suggest that osthol may exert a therapeutic effect on cardiac hypertrophy in rats, and its mechanisms may be related to the improvement of myocardial oxidative stress and lipid metabolism via regulation of PPARα-mediated target gene expressions including an increase in CPT-1a mRNA expression and a decrease in DGAT mRNA expression.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 4.0933 mL 20.4666 mL 40.9333 mL 81.8666 mL 102.3332 mL
    5 mM 0.8187 mL 4.0933 mL 8.1867 mL 16.3733 mL 20.4666 mL
    10 mM 0.4093 mL 2.0467 mL 4.0933 mL 8.1867 mL 10.2333 mL
    50 mM 0.0819 mL 0.4093 mL 0.8187 mL 1.6373 mL 2.0467 mL
    100 mM 0.0409 mL 0.2047 mL 0.4093 mL 0.8187 mL 1.0233 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    O-Methylcedrelopsin; O-Methylcedrelopsin CFN92731 72916-61-1 C16H18O4 = 274.3 5mg QQ客服:3257982914
    月橘香豆精; 九里香内酯; Coumurrayin CFN99811 17245-25-9 C16H18O4 = 274.3 5mg QQ客服:3257982914
    (S)-8-[(3,3-二甲基环氧乙烷基)甲基]-5,7-二甲氧基-2H-1-苯并吡喃-2-酮; Sibiricin CFN97531 95188-34-4 C16H18O5 = 290.3 5mg QQ客服:215959384
    九里香甲素; Isomexoticin CFN97454 88585-86-8 C16H20O6 = 308.3 5mg QQ客服:2932563308
    九里香醇; Murraol CFN99097 109741-38-0 C15H16O4 = 260.3 5mg QQ客服:2932563308
    异味决明内酯醇; Casegravol CFN97693 74474-76-3 C15H16O5 = 276.29 5mg QQ客服:1413575084
    蛇床子素; Osthol CFN98765 484-12-8 C15H16O3 = 244.3 20mg QQ客服:1413575084
    橙皮内酯; Meranzin CFN98249 23971-42-8 C15H16O4 = 260.3 5mg QQ客服:2932563308
    水合蛇床子素; Osthol hydrate CFN90848 69219-24-5 C15H18O4 = 262.3 10mg QQ客服:2932563308
    3'-O-Methylmurraol; 3'-O-Methylmurraol CFN89183 1891097-17-8 C16H18O4 = 274.31 5mg QQ客服:2159513211

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