Info: Read More
  • 中药标准品生产商,产品定制服务
  • Alpha-葡萄素


    产品编号 CFN97068
    CAS编号 62218-13-7
    分子式 = 分子量 C42H30O9 = 678.7
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Phenols
    植物来源 The herbs of Carex humilis Leyss.
    产品名称 产品编号 CAS编号 包装 QQ客服
    Alpha-葡萄素 CFN97068 62218-13-7 1mg QQ客服:2159513211
    Alpha-葡萄素 CFN97068 62218-13-7 5mg QQ客服:2159513211
    Alpha-葡萄素 CFN97068 62218-13-7 10mg QQ客服:2159513211
    Alpha-葡萄素 CFN97068 62218-13-7 20mg QQ客服:2159513211
    1. 在您收到产品后请检查产品。如无问题,请将产品存入冰霜并且样品瓶保持密封,产品可以存放长达24个月(2-8摄氏度)。

    2. 只要有可能,产品溶解后,您应该在同一天应用于您的实验。 但是,如果您需要提前做预实验,或者需要全部溶解,我们建议您将溶液以等分试样的形式存放在-20℃的密封小瓶中。 通常,这些可用于长达两周。 使用前,打开样品瓶前,我们建议您将产品平衡至室温至少1小时。

    3. 需要更多关于溶解度,使用和处理的建议? 请发送电子邮件至
  • 1. 在线订购
  • 请联系我们QQ客服

  • 2. 电话订购
  • 请拨打电话:
    027-84237683 或 027-84237783

  • 3. 邮件或传真订购
  • 发送电子邮件到: 或

  • 提供订购信息
  • 为了方便客户的订购,请需要订购ChemFaces产品的客户,在下单的时候请提供下列信息,以供我们快速为您建立发货信息。
  • 1. 产品编号(CAS No.或产品名称)
  • 2. 发货地址
  • 3. 联系方法 (联系人,电话)
  • 4. 开票抬头 (如果需要发票的客户)
  • 5. 发票地址(发货地址与发票地址不同)
  • 发货时间
    1. 付款方式为100%预付款客户,我们将在确认收到货款后当天或1-3个工作日发货。

    2. 付款方式为月结的客户,我们承诺在收到订单后当天或1-3个工作日内发货。

    3. 如果客户所需要的产品,需要重新生产,我们有权告知客户,交货时间需要延期。

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.

    PMID: 30417089
  • Universidade Católica Portuguesa (Portugal)
  • Korea Institute of Oriental Medicine (Korea)
  • Vin?a Institute of Nuclear Sciences (Serbia)
  • Universidade Federal de Pernambuco (UFPE) (Brazil)
  • University of Ioannina (Greece)
  • University of Fribourg (Switzerland)
  • FORTH-IMBB (Greece)
  • Auburn University (USA)
  • University of Pretoria (South Africa)
  • National Cancer Institute (USA)
  • S.N.D.T. Women's University (India)
  • Tokyo Woman's Christian University (Japan)
  • Medical University of Gdansk (Poland)
  • Cancer Research Initatives Foundation(CARIF) (Malaysia)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Virulence.2018, 9(1):588-603
  • J Enzyme Inhib Med Chem.2019, 34(1):134-143
  • Exp Neurobiol.2018, 27(3):200-209
  • Neurotox Res.2022, 40(6):1937-1947.
  • Front Pharmacol.2021, 12:615157.
  • University of Limpopo2016, 1777
  • J Herbmed Pharmacol.2018, 7(4):280-286
  • Pharm Biol.2017, 55(1):360-366
  • Korean Journal of Pharmacognosy2019, 50(4):285-290
  • Applied Biological Chem. 2020, 26(63).
  • Exp Mol Med.2020, 52(4):629-642.
  • J Ethnopharmacol.2020, 254:112733.
  • Natural Product Communications2020, doi: 10.1177.
  • Plant J.2021, 107(6):1711-1723.
  • Pharmaceutics.2021, 13(11):1839.
  • Am J Chin Med.2023, 51(4):1019-1039.
  • Asian Pac J Cancer Prev.2019, 20(1):65-72
  • Cell Signal.2022, 99:110433.
  • Chemistry of Natural Compounds2019, 55(1):127-130
  • Front Plant Sci.2021, 12: 648426.
  • J Biochem Mol Toxicol.2017, 31(9)
  • Antioxidants (Basel).2020, 9(2): E119
  • J Traditional Thai Medical Res.2022, 8(1):pp1-14.
  • ...
  • 生物活性
    Description: Alpha-viniferin is a prostaglandin H2 synthase inhibitor, which has anti-inflammatory, anti-oxidant, anti-arthritis, and anti-tumor activities. Alpha-Viniferin inhibits AChE activity is specific, reversible and noncompetitive, in a dose-dependent manner, and the IC50 values of alpha-Viniferin were 2.0 microM. Alpha-Viniferin exhibits a dose-dependent inhibition on cyclooxygenase activity, where 50% of inhibition (IC50) was shown at a final concentration of about 7 microM, it down-regulates STAT-1-inducible inflammatory genes via inhibiting ERK-mediated STAT-1 activation in IFN-gamma-stimulated macrophages.
    Targets: P450 (e.g. CYP17) | NO | PGE | NOS | COX | NF-kB | Akt | PI3K | HO-1 | Nrf2 | IFN-γ | STAT | ERK | AChR
    In vitro:
    J Pharmacol Sci. 2010;112(4):405-14.
    alpha-Viniferin suppresses the signal transducer and activation of transcription-1 (STAT-1)-inducible inflammatory genes in interferon-gamma-stimulated macrophages.[Pubmed: 20424383]
    alpha-Viniferin, an oligostilbene of trimeric resveratrol, has been reported to have anti-inflammatory potential in carrageenin-induced paw edema or adjuvant-induced arthritis in animal models. However, little is known about the molecular basis.
    In this study, alpha-Viniferin at 3 - 10 microM dose-dependently inhibited interferon (IFN)-gamma-induced Ser(727) phosphorylation of the signal transducer and activation of transcription-1 (STAT-1), a pivotal transcription factor controlling IFN-gamma-targeted genes, in RAW 264.7 macrophages, and also IFN-gamma-induced activation of the extracellular signal-regulated kinase (ERK)-1, a protein kinase upstream of the Ser(727) phosphorylation of STAT-1. However, alpha-Viniferin, only at a higher concentration of 10 microM, inhibited Janus kinase 2-mediated Tyr(701) phosphorylation of STAT-1 in the cells. To understand STAT-1-dependent inflammatory responses, we quantified nitric oxide (NO) or chemokines. alpha-Viniferin at 3 - 10 muM dose-dependently inhibited IFN-gamma-induced production of NO, IFN-gamma-inducible protein-10 (IP-10), or the monokine induced by IFN-gamma (MIG) in RAW 264.7 cells and also that of NO in primary macrophages-derived from C57BL/6 mice. Furthermore, alpha-Viniferin diminished IFN-gamma-induced protein levels of inducible NO synthase (iNOS), attenuated mRNA levels of iNOS, IP-10, or MIG as well as inhibited promoter activity of the iNOS gene.
    In conclusion, this study proposes an anti-inflammatory mechanism of alpha-Viniferin, down-regulating STAT-1-inducible inflammatory genes via inhibiting ERK-mediated STAT-1 activation in IFN-gamma-stimulated macrophages.
    In vivo:
    Am J Chin Med. 2004;32(4):521-30.
    The effects of alpha-viniferin on adjuvant-induced arthritis in rats.[Pubmed: 15481642]
    This study was performed to assess the efficacy of alpha-Viniferin (Carex humilis Leyss) on adjuvant-induced arthritis in rats. Adjuvant arthritis was induced by a single subcutaneous injection of 0.1 ml complete Freund's adjuvant (CFA) containing 7.5 mg Mycobacterium butyricum suspended in 1 ml sterile paraffin oil into the right hind paw.
    Forty female Sprague-Dawley rats were injected. Righting reflex was uniformly lost and considered to be the initial point of arthritis development on day 7 after CFA injection. Rats were divided into four groups, and upon development of arthritis, tested groups were orally administered 3 or 10 mg/kg alpha-Viniferin or 10 mg/kg ketoprofen every day for 14 days. The control group was orally administered 2 ml of physiological saline solution. Bone mineral density (BMD), radiological changes and edematous volumes were measured for 35 days. alpha-Viniferin suppressed the development of inflammatory edema, and inhibited the bone destruction, noted with a decrease in BMD (p < 0.05). Hind paw edema volume, BMD and radiological changes did not differ significantly in the ketoprofen and alpha-Viniferin groups during the entire study period.
    In conclusion, alpha-Viniferin suppressed arthritic inflammation and bony change in rats.
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.4734 mL 7.367 mL 14.7341 mL 29.4681 mL 36.8351 mL
    5 mM 0.2947 mL 1.4734 mL 2.9468 mL 5.8936 mL 7.367 mL
    10 mM 0.1473 mL 0.7367 mL 1.4734 mL 2.9468 mL 3.6835 mL
    50 mM 0.0295 mL 0.1473 mL 0.2947 mL 0.5894 mL 0.7367 mL
    100 mM 0.0147 mL 0.0737 mL 0.1473 mL 0.2947 mL 0.3684 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    Carasiphenol C; Carasiphenol C CFN95045 868168-04-1 C42H32O9 = 680.7 5mg QQ客服:2056216494
    Carasinol D; Carasinol D CFN95044 1072797-66-0 C56H42O13 = 923.0 5mg QQ客服:215959384
    Caraganaphenol A; Caraganaphenol A CFN95093 174916-31-5 C56H42O13 = 923.0 5mg QQ客服:2159513211
    蒿草酚A; Kobophenol A CFN92530 124027-58-3 C56H44O13 = 925.0 10mg QQ客服:2056216494
    Carasinol B; Carasinol B CFN95042 777857-86-0 C56H44O13 = 925.0 5mg QQ客服:1413575084
    (-)-蛇葡萄素H; (-)-Ampelopsin H CFN93787 N/A C56H42O12 = 907.0 5mg QQ客服:1457312923
    Alpha-葡萄素; alpha-Viniferin CFN97068 62218-13-7 C42H30O9 = 678.7 10mg QQ客服:2159513211
    Caraphenol A; Caraphenol A CFN98469 354553-35-8 C42H28O9 = 676.7 5mg QQ客服:3257982914
    葡萄醇D; Viniferol D CFN97082 625096-18-6 C42H32O9 = 680.7 5mg QQ客服:215959384
    桑呋喃C; Mulberrofuran C CFN96132 77996-04-4 C34H28O9 = 580.6 5mg QQ客服:1413575084





    在线QQ: 1413575084


    ChemFaces为科学家,科研人员与企业提供快速的产品递送。我们通过瑞士SGS ISO 9001:2008质量体系认证天然化合物与对照品的研发和生产