| In vitro: |
| Zhongguo Zhong Yao Za Zhi. 2008 Jul;33(13):1569-72. | | Study of anti-oxidant phenolic compounds from stem barks of Morus yunanensis.[Pubmed: 18837317] | To study anti-oxidant phenolic compounds from stem barks of Morus yunanensis.
METHODS AND RESULTS:
Isolation and purification were carried out by silica gel, Sephadex LH -20 and RP - 18 column chromatography. The chemical structures of constituents were elucidated on the basis of physicochemical properties and spectral data. Eight phenolic compounds were isolated and identified as: mulberrofuran E (1), Mulberrofuran K (2), albanol B (3), kuwanon H (4), resveratrol (5), moracin M (6), morachalcone A (7), 3', 5', 2, 4-tetrahydroxy-4-(3-methyl-1-butenyl) stilbene (8).
CONCLUSIONS:
All the compounds were isolated from the plant for the first time, and compounds 2, 3, 6, 8 showed potent anti-oxidation activities. | | Planta Med. 2007 Nov;73(14):1481-5. | | Inhibition of HCV replicon cell growth by 2-arylbenzofuran derivatives isolated from Mori Cortex Radicis.[Pubmed: 17948170] | Medicinal herbs are increasingly used in the search for safe and efficient drug candidates for hepatitis C virus infection.
METHODS AND RESULTS:
In this study, we have investigated the anti-HCV effect of compounds from Mori Cortex Radicis. During a screening for extracts with anti-HCV affinity from medicinal plants (173 species), the methanol extract of Mori Cortex Radicis was selected. Fractionation of the extract by monitoring antiviral activity with a replicon cell-based assay resulted in the isolation of five compounds, mulberroside C ( 1), moracin P ( 2), moracin O ( 3), moracin M ( 4) and Mulberrofuran K ( 5) from the ethyl acetate-soluble fraction.
CONCLUSIONS:
Compounds 1 approximately 4 showed significant inhibitory activities. Compounds 2 and 3 showed potent inhibitory activity (IC (50) 35.6 microM, 80.8 microM, respectively) in the replicon cell assay, which was confirmed by NS3 helicase inhibitory activity (IC (50) 42.9 microM, 27.0 microM, respectively). |
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