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  • alpha-三联噻吩甲醇

    alpha-Terthienylmethanol

    alpha-三联噻吩甲醇
    产品编号 CFN99395
    CAS编号 13059-93-3
    分子式 = 分子量 C13H10OS3 = 278.4
    产品纯度 >=98%
    物理属性 Yellow powder
    化合物类型 Thiophenes
    植物来源 The herbs of Eclipta alba
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    alpha-三联噻吩甲醇 CFN99395 13059-93-3 1mg QQ客服:3257982914
    alpha-三联噻吩甲醇 CFN99395 13059-93-3 5mg QQ客服:3257982914
    alpha-三联噻吩甲醇 CFN99395 13059-93-3 10mg QQ客服:3257982914
    alpha-三联噻吩甲醇 CFN99395 13059-93-3 20mg QQ客服:3257982914
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Kitasato University (Japan)
  • Seoul National University (Korea)
  • University of Toronto (Canada)
  • Helmholtz Zentrum München (Germany)
  • Ateneo de Manila University (Philippines)
  • National Hellenic Research Foundation (Greece)
  • Center for protein Engineering (CIP) (Belgium)
  • University of Madras (India)
  • Shanghai Institute of Organic Chemistry (China)
  • Gyeongsang National University (Korea)
  • Istanbul University (Turkey)
  • University of Zurich (Switzerland)
  • Florida A&M University (USA)
  • Monash University Malaysia (Malaysia)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Cosmetics2021, 8(3),91.
  • Acta Pharm Sin B.2015, 5(4):323-9.
  • Food Chem.2023, 404(Pt A):134517.
  • Microorganisms.2021, 9(12):2514.
  • Revista Brasileira de Farmacognosia2021, 31:794-804.
  • Appl. Sci. 2021, 11(17),7829
  • Plant Physiol Biochem.2019, 144:355-364
  • Front Pharmacol.2017, 8:205
  • Nutrients.2017, 10(1)
  • Korean J. Medicinal Crop Sci.2021, 29(6):425-433
  • Indian J. of Experimental Bio.2020, 9(58).
  • Molecules.2021, 26(4):817.
  • Mol Cells.2018, 41(8):771-780
  • The Catharanthus Genome2022,35-83.
  • Pharmacognosy Journal2019, 11(2): 369-373
  • Nutrients.2020, 12(12):3638.
  • Mol Plant Pathol.2022, 10.1111:mpp.13280.
  • Sci Rep.2017, 7:46299
  • Front Immunol.2023, 14:1240800.
  • J Pharm Biomed Anal.2018, 151:32-41
  • Food Science and Biotechnology2022, 10.1007.
  • Appl. Sci.2021, 11(19),9343.
  • Journal of Research in Pharmacy.2022, 26(6):p1752-1757.
  • ...
  • 生物活性
    Description: Alpha-terthienylmethanol possesses potent cytotoxic activity against human endometrial cancer cells; it inhibits growth mediated by the induction of apoptosis, as shown by the accumulation of sub-G1 and apoptotic cells.
    Targets: NADPH-oxidase | ROS
    In vitro:
    J Ethnopharmacol. 2015 May 1.
    α-Terthienylmethanol, isolated from Eclipta prostrata, induces apoptosis by generating reactive oxygen species via NADPH oxidase in human endometrial cancer cells.[Pubmed: 25940205]
    Eclipta prostrate L. (syn. E. alba Hassk), commonly known as False Daisy, has been used in traditional medicine in Asia to treat a variety of diseases, including cancer. Although an anti-tumor effect has been suggested for E. prostrata, the exact anti-tumor effects and underlying molecular mechanisms of its bioactive compounds are poorly understood. The aim of this study was to identify compounds with anti-cancer activity from E. prostrata and to investigate their mechanism of action.
    METHODS AND RESULTS:
    To assess cell viability, cell cycle progression, and apoptosis, we performed MTT assays and FACS analysis using Annexin and PI staining. We also investigated reactive oxygen species (ROS) production and caspase activation using flow cytometry and Western blot analysis, respectively. Cytosolic translocation of cytochrome c was measured using an ELISA kit. Antioxidants, MAPK signaling inhibitors, NADPH oxidase inhibitors, and siRNA were used to elucidate the molecular mechanism of action of the compound. We isolated five terthiophenes from the n-hexane fraction of E. prostrata; of these, α-terthienylmethanol possessed potent cytotoxic activity against human endometrial cancer cells (Hec1A and Ishikawa) (IC50<1μM). The growth inhibitory effect of alpha-Terthienylmethanol was mediated by the induction of apoptosis, as shown by the accumulation of sub-G1 and apoptotic cells. In addition, alpha-Terthienylmethanol triggered caspase activation and cytochrome c release into the cytosol in a time-dependent manner. Moreover, alpha-Terthienylmethanol increased the intracellular level of ROS and decreased that of GSH, and the antioxidants N-acetyl-l-cysteine and catalase significantly attenuated alpha-Terthienylmethanol-induced apoptosis. We further demonstrated that inhibition of the NADPH oxidase attenuated alpha-Terthienylmethanol-induced cell death and ROS accumulation in endometrial cancer cells.
    CONCLUSIONS:
    Overall, these results suggest that alpha-Terthienylmethanol, a naturally occurring terthiophene isolated from E. prostrata, induces apoptosis in human endometrial cancer cells by ROS production, partially via NADPH oxidase.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.592 mL 17.9598 mL 35.9195 mL 71.8391 mL 89.7989 mL
    5 mM 0.7184 mL 3.592 mL 7.1839 mL 14.3678 mL 17.9598 mL
    10 mM 0.3592 mL 1.796 mL 3.592 mL 7.1839 mL 8.9799 mL
    50 mM 0.0718 mL 0.3592 mL 0.7184 mL 1.4368 mL 1.796 mL
    100 mM 0.0359 mL 0.1796 mL 0.3592 mL 0.7184 mL 0.898 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    1-chloro-6-(5-ethynylthiophen-2-yl)hexa-3,5-diyn-2-ol; 1-chloro-6-(5-ethynylthiophen-2-yl)hexa-3,5-diyn-2-ol CFN97271 78876-53-6 C12H7ClOS = 234.7 5mg QQ客服:1413575084
    1-chloro-6-(5-(prop-1-ynyl)thiophen-2-yl)hexa-3,5-diyn-2-ol; 1-chloro-6-(5-(prop-1-ynyl)thiophen-2-yl)hexa-3,5-diyn-2-ol CFN97270 78876-52-5 C13H9ClOS = 248.7 5mg QQ客服:2159513211
    噻吩A(二醇噻吩E); Echinoynethiophene A CFN97103 64165-98-6 C13H10O2S = 230.3 5mg QQ客服:3257982914
    2(-4-Chloro-3-hydroxy-1-butynyl)-5-1,(3-pentadiynyl)thiophene; 2(-4-Chloro-3-hydroxy-1-butynyl)-5-1,(3-pentadiynyl)thiophene CFN98322 26905-70-4 C13H9ClOS = 248.7 5mg QQ客服:1457312923
    牛蒡子醇B; Arctinol B CFN99036 102054-39-7 C13H12O2S2 = 264.4 5mg QQ客服:2159513211
    2-Chloro-1-(5'-(prop-1-ynyl)-2,2'-bithiophen-5-yl)ethanol; 2-Chloro-1-(5'-(prop-1-ynyl)-2,2'-bithiophen-5-yl)ethanol CFN99247 114916-00-6 C13H11ClOS2 = 282.8 5mg QQ客服:1413575084
    alpha-三联噻吩甲醇; alpha-Terthienylmethanol CFN99395 13059-93-3 C13H10OS3 = 278.4 5mg QQ客服:2159513211

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