山椒子烯酮

Zeylenone

	产品编号	CFN93098
	CAS编号	193410-84-3
	分子式 = 分子量	C₂₁H₁₈O₇ = 382.36
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Miscellaneous
	植物来源	The herbs of Uvaria grandiflora
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
山椒子烯酮	CFN93098	193410-84-3	1mg	QQ客服：1413575084
山椒子烯酮	CFN93098	193410-84-3	5mg	QQ客服：1413575084
山椒子烯酮	CFN93098	193410-84-3	10mg	QQ客服：1413575084
山椒子烯酮	CFN93098	193410-84-3	20mg	QQ客服：1413575084

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Mahatma Gandhi University (India)

Kazusa DNA Research Institute (Japan)

CSIRO - Agriculture Flagship (Australia)

Charles Sturt University (Denmark)

Korea Institute of Oriental Medicine (Korea)

VIT University (India)

Universidad Veracuzana (Mexico)

Lodz University of Technology (Poland)

The Institute of Cancer Research (United Kingdom)

Seoul National University of Science and Technology (Korea)

Molecular Biology Institute of Barcelona (IBMB)-CSIC (Spain)

Wroclaw Medical University (Poland)

Complutense University of Madrid (Spain)

University of Helsinki (Finland)

More...

Description:

Zeylenone has good antitumor efficacy, it inhibits proliferation and induces apoptosis in cervical carcinoma cells via PI3K/AKT/mTOR and MAPK/ERK pathways. Zeylenone shows inhibitory activity toward the root growth of Lactuca sativa.

Targets:

PI3K | mTOR | Akt | MAPK | ERK

In vitro:

J Proteomics. 2015 Aug 3;126:279-87.

Quantitative analysis of differential protein expression in cervical carcinoma cells after zeylenone treatment by stable isotope labeling with amino acids in cell culture.[Pubmed: 26130516 ]

Cervical carcinoma is a malignant tumor that poses a serious threat to women's health and survival. Approximately 10-25% of cervical cancers are adenocarcinomas (ACs). AC has high rates of recurrence and mortality, while there is no effective treatment for now. Zeylenone (Zey), which is isolated from an ethanol extract of the leaves of Uvaria grandiflora Roxb. of the family Annonaceae, has shown potent inhibitory activity against various tumor cells, including cervical carcinoma cells. To gain insight into the molecular mechanism underlying the effect of Zey on AC, we quantified protein expression changes in AC cells treated with Zey.
METHODS AND RESULTS:
We used stable isotope labeling with amino acids in cell culture (SILAC) in combination with high-performance liquid chromatography-electrospray ionization tandem mass spectrometry (HPLC-ESI-MS/MS) and bioinformatics analysis to compare protein expression profiles in HeLa cells before and after Zey treatment. Of 1805 differentially expressed proteins identified, 229 were screened as key protein molecules and classified into nine categories.
CONCLUSIONS:
Profiling of differentially-expressed proteins contributed to our understanding of the molecular mechanism by which Zey induces HeLa cell apoptosis. Using this method, candidate targets can be identified for developing new drugs against cervical carcinoma.

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灵芝酸DM; Ganoderic acid DM	CFN99815	173075-45-1	C₃₀H₄₄O₄ = 468.7	5mg	QQ客服：1413575084
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儿茶素-7-O-β-呲喃葡萄糖苷; Catechin 7-O-beta-D-glucopyranoside	CFN95524	65597-47-9	C₂₁H₂₄O₁₁ = 452.4	20mg	QQ客服：3257982914
香草酸葡萄糖酯; 1-O-Vanilloylglucose	CFN95663	68985-14-8	C₁₄H₁₈O₉ = 330.3	5mg	QQ客服：1457312923

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	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.6153 mL	13.0767 mL	26.1534 mL	52.3067 mL	65.3834 mL
5 mM	0.5231 mL	2.6153 mL	5.2307 mL	10.4613 mL	13.0767 mL
10 mM	0.2615 mL	1.3077 mL	2.6153 mL	5.2307 mL	6.5383 mL
50 mM	0.0523 mL	0.2615 mL	0.5231 mL	1.0461 mL	1.3077 mL
100 mM	0.0262 mL	0.1308 mL	0.2615 mL	0.5231 mL	0.6538 mL