环安坦-3,24,25-三醇

Cycloartane-3,24,25-triol

	产品编号	CFN98972
	CAS编号	57576-29-1
	分子式 = 分子量	C₃₀H₅₂O₃ = 460.7
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Triterpenoids
	植物来源	The barks of Aphanamixis polystachya
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

提供自定义包装

产品名称	产品编号	CAS编号	包装	QQ客服
环安坦-3,24,25-三醇	CFN98972	57576-29-1	1mg	QQ客服：2056216494
环安坦-3,24,25-三醇	CFN98972	57576-29-1	5mg	QQ客服：2056216494
环安坦-3,24,25-三醇	CFN98972	57576-29-1	10mg	QQ客服：2056216494
环安坦-3,24,25-三醇	CFN98972	57576-29-1	20mg	QQ客服：2056216494

存储与注意事项

1. 在您收到产品后请检查产品。如无问题，请将产品存入冰霜并且样品瓶保持密封，产品可以存放长达24个月（2-8摄氏度）。

2. 只要有可能，产品溶解后，您应该在同一天应用于您的实验。但是，如果您需要提前做预实验，或者需要全部溶解，我们建议您将溶液以等分试样的形式存放在-20℃的密封小瓶中。通常，这些可用于长达两周。使用前，打开样品瓶前，我们建议您将产品平衡至室温至少1小时。

3. 需要更多关于溶解度，使用和处理的建议？请发送电子邮件至：service@chemfaces.com

订购流程

1. 在线订购

请联系我们QQ客服

2. 电话订购

请拨打电话：
027-84237683 或 027-84237783

3. 邮件或传真订购

发送电子邮件到: manager@chemfaces.com 或
发送传真到：027-84254680

提供订购信息

为了方便客户的订购，请需要订购ChemFaces产品的客户，在下单的时候请提供下列信息，以供我们快速为您建立发货信息。

1. 产品编号（CAS No.或产品名称）

2. 发货地址

3. 联系方法 (联系人，电话）

4. 开票抬头 (如果需要发票的客户）

5. 发票地址（发货地址与发票地址不同）

发货时间

1. 付款方式为100%预付款客户，我们将在确认收到货款后当天或1-3个工作日发货。

2. 付款方式为月结的客户，我们承诺在收到订单后当天或1-3个工作日内发货。

3. 如果客户所需要的产品，需要重新生产，我们有权告知客户，交货时间需要延期。

ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Mahatma Gandhi University (India)

Massachusetts General Hospital (USA)

Donald Danforth Plant Science Center (USA)

Washington State University (USA)

University of Padjajaran (Indonesia)

Indian Institute of Science (India)

National Cancer Institute (USA)

Nanjing University of Chinese Medicine (China)

Harvard University (USA)

Regional Crop Research Institute (Korea)

University Medical Center Mainz (Germany)

Universidad Miguel Hernández (Spain)

Helmholtz Zentrum München (Germany)

MTT Agrifood Research Finland (Finland)

More...

Description:

Cycloartane-3,24,25-triol has potential for development as an anti-cancer agent against prostate cancer. It reduces the viability of PC-3 and DU145 cell lines with IC50 values of 2.226 ± 0.28 μM and 1.67 ± 0.18 μM respectively.

Targets:

ATPase

In vitro:

Cancer Cell Int. 2012 Nov 14;12(1):46.

Cycloartane-3,24,25-triol inhibits MRCKα kinase and demonstrates promising anti prostate cancer activity in vitro.[Pubmed: 23151005]

Given the high occurrence of prostate cancer worldwide and one of the major sources of the discovery of new lead molecules being medicinal plants, this research undertook to investigate the possible anti-cancer activity of two natural cycloartanes; cycloartane-3,24,25-diol (extracted in our lab from Tillandsia recurvata) and Cycloartane-3,24,25-triol (purchased). The inhibition of MRCKα kinase has emerged as a potential solution to restoring the tight regulation of normal cellular growth, the loss of which leads to cancer cell formation.
METHODS AND RESULTS:
Kinase inhibition was investigated using competition binding (to the ATP sites) assays which have been previously established and authenticated and cell proliferation was measured using the WST-1 assay. Cycloartane-3,24,25-triol demonstrated strong selectivity towards the MRCKα kinase with a Kd50 of 0.26 μM from a total of 451 kinases investigated. Cycloartane-3,24,25-triol reduced the viability of PC-3 and DU145 cell lines with IC50 values of 2.226 ± 0.28 μM and 1.67 ± 0.18 μM respectively.
CONCLUSIONS:
These results will prove useful in drug discovery as Cycloartane-3,24,25-triol has shown potential for development as an anti-cancer agent against prostate cancer.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
升麻酮醇-3-O-α-L-吡喃阿拉伯糖苷; Cimicidanol 3-O-alpha-L-arabinoside	CFN90863	161207-05-2	C₃₅H₅₂O₉ = 616.8	10mg	QQ客服：1457312923
黑升麻苷H-1; Cimicifugoside H1	CFN92973	163046-73-9	C₃₅H₅₂O₉ = 616.78	10mg	QQ客服：1413575084
23-O-Acetylshengmanol 3-O-beta-D-xyloside; 23-O-Acetylshengmanol 3-O-beta-D-xyloside	CFN92970	62498-88-8	C₃₇H₅₈O₁₀ = 662.85	5mg	QQ客服：3257982914
(3beta,23E)-9,19-环羊毛甾-23-烯-3,25-二醇; Cycloart-23-ene-3,25-diol	CFN90498	14599-48-5	C₃₀H₅₀O₂ = 442.72	5mg	QQ客服：1413575084
(3beta,22E)-9,19-环羊毛甾-22-烯-3,25-二醇; Cycloart-22-ene-3,25-diol	CFN97555	97456-49-0	C₃₀H₅₀O₂ = 442.7	5mg	QQ客服：3257982914
环羊毛甾-24-烯-1alpha,2alpha,3beta-三醇; Cycloart-24-ene-1alpha,2alpha,3beta-triol	CFN91991	942407-97-8	C₃₀H₅₀O₃ = 458.72	5mg	QQ客服：2056216494
29-去甲羊毛甾-8,24-二烯-1alpha,2alpha,3beta-三醇; 29-Norlanosta-8,24-diene-1alpha,2alpha,3beta-triol	CFN91990	119765-92-3	C₂₉H₄₈O₃ = 444.69	5mg	QQ客服：1457312923
25-羟基环木菠萝-23-烯-3-酮; 25-Hydroxycycloart-23-en-3-one	CFN99613	148044-47-7	C₃₀H₄₈O₂ = 440.7	5mg	QQ客服：2159513211
29-去甲环安坦-23-烯-3,25-二醇; 29-Norcycloart-23-ene-3,25-diol	CFN97849	115040-04-5	C₂₉H₄₈O₂ = 428.7	5mg	QQ客服：1413575084
环安坦-3,24,25-三醇; Cycloartane-3,24,25-triol	CFN98972	57576-29-1	C₃₀H₅₂O₃ = 460.7	5mg	QQ客服：1457312923

信息支持

公司简介
订购流程
付款方式
退换货政策

ChemFaces提供的产品仅用于科学研究使用，不用于诊断或治疗程序。

联系方式

电机：027-84237783
传真：027-84254680
在线QQ: 1413575084
E-Mail：manager@chemfaces.com

湖北省武汉沌口经济技术开区车城南路83号1号楼第三层厂房

ChemFaces为科学家，科研人员与企业提供快速的产品递送。我们通过瑞士SGS ISO 9001:2008质量体系认证天然化合物与对照品的研发和生产。

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.1706 mL	10.853 mL	21.7061 mL	43.4122 mL	54.2652 mL
5 mM	0.4341 mL	2.1706 mL	4.3412 mL	8.6824 mL	10.853 mL
10 mM	0.2171 mL	1.0853 mL	2.1706 mL	4.3412 mL	5.4265 mL
50 mM	0.0434 mL	0.2171 mL	0.4341 mL	0.8682 mL	1.0853 mL
100 mM	0.0217 mL	0.1085 mL	0.2171 mL	0.4341 mL	0.5427 mL