环安坦-3,24,25-三醇

Cycloartane-3,24,25-triol

	产品编号	CFN98972
	CAS编号	57576-29-1
	分子式 = 分子量	C₃₀H₅₂O₃ = 460.7
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Triterpenoids
	植物来源	The barks of Aphanamixis polystachya
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
环安坦-3,24,25-三醇	CFN98972	57576-29-1	1mg	QQ客服：3257982914
环安坦-3,24,25-三醇	CFN98972	57576-29-1	5mg	QQ客服：3257982914
环安坦-3,24,25-三醇	CFN98972	57576-29-1	10mg	QQ客服：3257982914
环安坦-3,24,25-三醇	CFN98972	57576-29-1	20mg	QQ客服：3257982914

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Martin Luther University of Halle-Wittenberg (Germany)

University of Pretoria (South Africa)

Universidad de Ciencias y Artes de Chiapas (Mexico)

Washington State University (USA)

National Hellenic Research Foundation (Greece)

Korea Institute of Oriental Medicine (Korea)

Heinrich-Heine-University Düsseldorf (Germany)

Shanghai Institute of Organic Chemistry (China)

Cornell University (USA)

Aveiro University (Portugal)

Chungnam National University (Korea)

Worcester Polytechnic Institute (USA)

The Ohio State University (USA)

Univerzita Karlova v Praze (Czech Republic)

More...

Description:

Cycloartane-3,24,25-triol has potential for development as an anti-cancer agent against prostate cancer. It reduces the viability of PC-3 and DU145 cell lines with IC50 values of 2.226 ± 0.28 μM and 1.67 ± 0.18 μM respectively.

Targets:

ATPase

In vitro:

Cancer Cell Int. 2012 Nov 14;12(1):46.

Cycloartane-3,24,25-triol inhibits MRCKα kinase and demonstrates promising anti prostate cancer activity in vitro.[Pubmed: 23151005]

Given the high occurrence of prostate cancer worldwide and one of the major sources of the discovery of new lead molecules being medicinal plants, this research undertook to investigate the possible anti-cancer activity of two natural cycloartanes; cycloartane-3,24,25-diol (extracted in our lab from Tillandsia recurvata) and Cycloartane-3,24,25-triol (purchased). The inhibition of MRCKα kinase has emerged as a potential solution to restoring the tight regulation of normal cellular growth, the loss of which leads to cancer cell formation.
METHODS AND RESULTS:
Kinase inhibition was investigated using competition binding (to the ATP sites) assays which have been previously established and authenticated and cell proliferation was measured using the WST-1 assay. Cycloartane-3,24,25-triol demonstrated strong selectivity towards the MRCKα kinase with a Kd50 of 0.26 μM from a total of 451 kinases investigated. Cycloartane-3,24,25-triol reduced the viability of PC-3 and DU145 cell lines with IC50 values of 2.226 ± 0.28 μM and 1.67 ± 0.18 μM respectively.
CONCLUSIONS:
These results will prove useful in drug discovery as Cycloartane-3,24,25-triol has shown potential for development as an anti-cancer agent against prostate cancer.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
25-羟基环木菠萝-23-烯-3-酮; 25-Hydroxycycloart-23-en-3-one	CFN99613	148044-47-7	C₃₀H₄₈O₂ = 440.7	5mg	QQ客服：2159513211
29-去甲环安坦-23-烯-3,25-二醇; 29-Norcycloart-23-ene-3,25-diol	CFN97849	115040-04-5	C₂₉H₄₈O₂ = 428.7	5mg	QQ客服：3257982914
环安坦-3,24,25-三醇; Cycloartane-3,24,25-triol	CFN98972	57576-29-1	C₃₀H₅₂O₃ = 460.7	5mg	QQ客服：215959384
(24S)-环安坦-3,24,25-三醇24,25-缩丙酮; (24S)-Cycloartane-3,24,25-triol 24,25-acetonide	CFN98973	57576-31-5	C₃₃H₅₆O₃ = 500.8	5mg	QQ客服：2159513211
24,25-二羟基环木菠萝烷-3-酮; 24,25-Dihydroxycycloartan-3-one	CFN99653	155060-48-3	C₃₀H₅₀O₃ = 458.7	5mg	QQ客服：2159513211
栀子花乙酸; Gardenolic acid B	CFN96838	108864-53-5	C₃₀H₄₆O₅ = 486.69	5mg	QQ客服：3257982914
黑升麻苷H-2; Cimicifugoside H2	CFN92972	161097-77-4	C₃₅H₅₄O₁₀ = 634.8	5mg	QQ客服：2056216494
升麻酮醇-3-O-α-L-吡喃阿拉伯糖苷; Cimicidanol 3-O-alpha-L-arabinoside	CFN90863	161207-05-2	C₃₅H₅₂O₉ = 616.8	10mg	QQ客服：3257982914
黑升麻苷H-1; Cimicifugoside H1	CFN92973	163046-73-9	C₃₅H₅₂O₉ = 616.78	10mg	QQ客服：3257982914
23-O-Acetylshengmanol 3-O-beta-D-xyloside; 23-O-Acetylshengmanol 3-O-beta-D-xyloside	CFN92970	62498-88-8	C₃₇H₅₈O₁₀ = 662.85	5mg	QQ客服：2056216494

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	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.1706 mL	10.853 mL	21.7061 mL	43.4122 mL	54.2652 mL
5 mM	0.4341 mL	2.1706 mL	4.3412 mL	8.6824 mL	10.853 mL
10 mM	0.2171 mL	1.0853 mL	2.1706 mL	4.3412 mL	5.4265 mL
50 mM	0.0434 mL	0.2171 mL	0.4341 mL	0.8682 mL	1.0853 mL
100 mM	0.0217 mL	0.1085 mL	0.2171 mL	0.4341 mL	0.5427 mL