| In vitro: |
| Chem Pharm Bull (Tokyo). 2002 Sep;50(9):1250-4. | | Seven germacranolides, eupaglehnins A, B, C, D, E, and F, and 2alpha-acetoxyepitulipinolide from Eupatorium glehni.[Reference: WebLink] | We have been interested in biologically active terpenoids from Compositae9—14) and collected E. glehni6—8) in Tokushima and Hokkaido, Japan.
METHODS AND RESULTS:
From the ethyl acetate-soluble fraction of the methanol extract, we have found four new germacranolides with unsaturated esters at the 8-position, eupaglehnin A, eupaglehnin B, Eupaglehnin C, and eupaglehnin D, and two new chlorine atom-containing germacranolides, eupaglehnin E (5) and eupaglehnin F (6),13) as well as 2a-acetoxyepitulipinolide (7) for the first time from natural sources. In our attempt to find cytotoxic compounds, eupatoriopicrin (8) 24—29) was the most effective (1.40 mg/ml), followed by Eupaglehnin C (3) (2.19 mg/ml) against HeLa-S3. However, eupaglehnin E (5) and eupaglehnin F (6) did not show cytotoxic activity, which is understandable because they had no exomethylene group.
CONCLUSIONS:
In preliminary experiments, eupatoriopicrin (8) 24—26) also showed apoptotic activity against Ha-60 cell lines, the details of which will be published in due course. |
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