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  • 长春瑞滨

    Vinorelbine

    长春瑞滨
    产品编号 CFN90401
    CAS编号 71486-22-1
    分子式 = 分子量 C45H54N4O8 = 778.93
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Alkaloids
    植物来源 The herbs of Catharanthus roseus
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    长春瑞滨 CFN90401 71486-22-1 10mg QQ客服:1457312923
    长春瑞滨 CFN90401 71486-22-1 20mg QQ客服:1457312923
    长春瑞滨 CFN90401 71486-22-1 50mg QQ客服:1457312923
    长春瑞滨 CFN90401 71486-22-1 100mg QQ客服:1457312923
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Nanjing University of Chinese Medicine (China)
  • Kazusa DNA Research Institute (Japan)
  • Northeast Normal University Changchun (China)
  • Universidade Federal de Goias (UFG) (Brazil)
  • National Chung Hsing University (Taiwan)
  • The Ohio State University (USA)
  • Seoul National University of Science and Technology (Korea)
  • Complutense University of Madrid (Spain)
  • University of Hull (United Kingdom)
  • Universite de Lille1 (France)
  • Center for protein Engineering (CIP) (Belgium)
  • University of Virginia (USA)
  • University of Madras (India)
  • Rio de Janeiro State University (Brazil)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Heliyon.2022, 8(12):e12031.
  • Applied Biological Chemistry2022, 65(77).
  • FEMS Microbiol Lett.2017, 364(11)
  • Int Immunopharmacol.2022, 106:108603.
  • Pharmaceuticals (Basel).2024, 17(4):462.
  • Arabian Journal of Chemistry2024, 17(3):105648
  • J Ethnopharmacol.2017, 206:327-336
  • SCOPUS.2020, 836-847.
  • Analytical sci. & Tech2016, 186-193
  • Molecules.2023, 28(8):3291.
  • Antioxidants (Basel).2022, 11(12):2496.
  • PLoS One.2018, 13(11):e0208055
  • Phytochem Anal.2016, 27(5):296-303
  • Appl. Sci.2023, 13(17):9984.
  • Nat Prod Sci.2018, 24(2):109-114
  • Nutrients.2022, 14(16):3393.
  • Hindawi J of Food Biochemistry2023, P17:8883860
  • APMIS.2019, 127(10):688-695
  • Int J Mol Sci.2021, 22(10):5181.
  • Molecules.2022, 27(7):2360.
  • Research on Crops.2017, 18(3):569
  • LWT - Food Science and Technology2022, 164:113627
  • Microchemical Journal2022, 182: 107874.
  • ...
  • 生物活性
    Description: Vinorelbine is a semi-synthetic Vinca alkaloid which is currently used in treatment of different cancer types mainly advanced breast cancer (ABC) and advanced/metastatic non-small cell lung cancer (NSCLC). Vinorelbine-loaded SSM can be developed as a new, safe, stable, and effective nanomedicine for the treatment of breast and lung cancers.
    In vivo:
    Lung Cancer. 2015 May;88(2):167-73.
    Intravenous or oral administration of vinorelbine in adjuvant chemotherapy with cisplatin and vinorelbine for resected NSCLC.[Pubmed: 25769883 ]
    Cisplatin and Vinorelbine given intravenously is a well-established adjuvant chemotherapy regimen after surgery for early-stage NSCLC. Vinorelbine can also be administered orally. However, the efficacy of orally administrated Vinorelbine in adjuvant treatment of NSCLC is unknown. We assessed the overall survival (OS) and disease-free survival (DFS) of patients treated with adjuvant i.v. Vinorelbine or p.o. Vinorelbine, in combination with i.v. cisplatin.
    METHODS AND RESULTS:
    We reviewed two time-separated cohorts of patients referred to the Department of Oncology at Aarhus University Hospital (Denmark) from 2005 to 2012 for adjuvant chemotherapy after surgery for NSCLC. RESULTS AND Of the 265 patients included in this study, 126 patients received i.v. and 139 received p.o. Vinorelbine/cisplatin. The two groups were comparable with respect to important baseline characteristics. Median OS for all patients was 78.7 months and the median DFS was 35.7 months. No statistically significant difference in OS or DFS for patients treated with i.v. or oral Vinorelbine was detected. The DFS rates of the two groups were comparable across all variables in subgroup analysis.
    CONCLUSIONS:
    In conclusion we observed that intravenous or oral administration of Vinorelbine in combination with cisplatin after surgery for NSCLC appear equally effective in terms of overall and disease-free survival.
    Expert Opin Pharmacother. 2014 Aug;15(11):1585-99.
    Oral vinorelbine in the treatment of non-small-cell lung cancer.[Pubmed: 24972635]
    Originally formulated as an intravenous (i.v.) agent, Vinorelbine is also currently available as an oral chemotherapeutic agent.
    METHODS AND RESULTS:
    Oral Vinorelbine has demonstrated significant activity in different settings for NSCLC, including adjuvant treatment for resected disease, concurrent chemoradiation for locally advanced NSCLC and palliative chemotherapy for recurrent/metastatic NSCLC, as part of combination schedules or as a single-agent treatment. AREAS COVERED: The authors explored the available data describing the use of oral Vinorelbine in NSCLC. PubMed articles and abstracts presented at international conferences were analysed, and relevant trials were reported and discussed. Specific settings, including the treatment of elderly and unfit patients and metronomic schedules including oral Vinorelbine, were evaluated. Available pharmacoeconomic data were also assessed.
    CONCLUSIONS:
    Oral Vinorelbine is an appealing agent, particularly as part of combination regimens containing platinum derivatives, although it can have a role as a single-agent treatment as well. Its safety profile is generally favourable and its route of administration is generally preferred by patients receiving chemotherapy. Compared to i.v. Vinorelbine and other antineoplastic agents, oral Vinorelbine has been reported to be advantageous in terms of cost savings.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.2838 mL 6.4191 mL 12.8381 mL 25.6762 mL 32.0953 mL
    5 mM 0.2568 mL 1.2838 mL 2.5676 mL 5.1352 mL 6.4191 mL
    10 mM 0.1284 mL 0.6419 mL 1.2838 mL 2.5676 mL 3.2095 mL
    50 mM 0.0257 mL 0.1284 mL 0.2568 mL 0.5135 mL 0.6419 mL
    100 mM 0.0128 mL 0.0642 mL 0.1284 mL 0.2568 mL 0.321 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    酒石酸长春瑞滨; Vinorelbine Tartrate CFN90142 125317-39-7 C53H66N4O20 = 1079.11 20mg QQ客服:2159513211
    硫酸长春碱; Vinblastine Sulfate CFN90146 143-67-9 C46H58N4O9.H2SO4 = 909.06 20mg QQ客服:2056216494
    长春碱; Vinblastine CFN90230 865-21-4 C46H58N4O9 = 810.96 20mg QQ客服:1413575084
    脱水长春碱; 3',4'-Anhydrovinblastine CFN90246 38390-45-3 C46H56N4O8 = 792.96 5mg QQ客服:1457312923
    硫酸长春新碱; Vincristine sulfate CFN90400 2068-78-2 C46H58N4O14S = 923.04 20mg QQ客服:2056216494
    长春瑞滨; Vinorelbine CFN90401 71486-22-1 C45H54N4O8 = 778.93 20mg QQ客服:3257982914
    长春地辛; Vindesine CFN90465 53643-48-4 C43H55N5O7 = 753.92 5mg QQ客服:1413575084
    环氧长春碱,长春素; Vinleurosine CFN90466 23360-92-1 C46H56N4O9 = 808.95 5mg QQ客服:2056216494
    长春新碱; Vincristine CFN98589 57-22-7 C46H56N4O10 = 824.96 20mg QQ客服:215959384

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