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  • 脱水长春碱

    3',4'-Anhydrovinblastine

    脱水长春碱
    产品编号 CFN90246
    CAS编号 38390-45-3
    分子式 = 分子量 C46H56N4O8 = 792.96
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Alkaloids
    植物来源 The herbs of Catharanthus roseus (L.)G. Don
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    脱水长春碱 CFN90246 38390-45-3 1mg QQ客服:2056216494
    脱水长春碱 CFN90246 38390-45-3 5mg QQ客服:2056216494
    脱水长春碱 CFN90246 38390-45-3 10mg QQ客服:2056216494
    脱水长春碱 CFN90246 38390-45-3 20mg QQ客服:2056216494
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Cardiovasc Toxicol.2019, 19(4):297-305
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  • J Nat Med.2021, doi: 10.1007.
  • Pharmaceutics.2022, 14(5):945.
  • Chem Res Toxicol. 2022, acs.chemrestox.2c00049.
  • Molecules 2022, 27(3),960.
  • Nutrients2023, 15(18), 4016.
  • Biomolecules.2023, 13(2):227.
  • Antioxidants (Basel).2021, 10(10):1638.
  • J Nat Med.2020, 74(3):550-560.
  • Appl. Sci. 2021, 11(22), 10552
  • Virus Res.2023, 335:199199.
  • Molecules.2023, 28(7):3039.
  • J Cell Physiol.2021, 236(3):1950-1966.
  • Journal of Molecular Liquids2021, 334:116014.
  • Front Pharmacol.2021, 12:761922.
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  • ...
  • 生物活性
    Description: 3',4'-Anhydrovinblastine is an antineoplastic agent.
    In vitro:
    Biotechnol Appl Biochem. 2009 Apr;52(Pt 4):313-23.
    Production and metabolic engineering of terpenoid indole alkaloids in cell cultures of the medicinal plant Catharanthus roseus (L.) G. Don (Madagascar periwinkle).[Pubmed: 19281450 ]

    METHODS AND RESULTS:
    The Madagascar periwinkle [Catharanthus roseus (L.) G. Don] is a plant species known for its production of TIAs (terpenoid indole alkaloids), many of which are pharmaceutically important. Ajmalicine and serpentine are prescribed for the treatment of hypertension, whereas the bisindoles vinblastine, vincristine and 3',4'-Anhydrovinblastine are used for their antineoplastic activity in the treatment of many cancers. However, TIAs are produced in small yields in C. roseus, which make them expensive. Cell and metabolic engineering has focused on increasing flux through the TIA pathway by various means, including optimization of medium composition, elicitation, construction of noval culture systems and introduction of genes encoding specific metabolic enzymes into the C. roseus genome.
    CONCLUSIONS:
    The present review will attempt to present the state-of-the-art of research in this area and provide an update on the cell and metabolic engineering of TIAs in C. roseus. We hope that this will contribute to a better understanding of the ways in which TIA production can be achieved in different C. roseus culture systems.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.2611 mL 6.3055 mL 12.611 mL 25.222 mL 31.5274 mL
    5 mM 0.2522 mL 1.2611 mL 2.5222 mL 5.0444 mL 6.3055 mL
    10 mM 0.1261 mL 0.6305 mL 1.2611 mL 2.5222 mL 3.1527 mL
    50 mM 0.0252 mL 0.1261 mL 0.2522 mL 0.5044 mL 0.6305 mL
    100 mM 0.0126 mL 0.0631 mL 0.1261 mL 0.2522 mL 0.3153 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    酒石酸长春瑞滨; Vinorelbine Tartrate CFN90142 125317-39-7 C53H66N4O20 = 1079.11 20mg QQ客服:1457312923
    硫酸长春碱; Vinblastine Sulfate CFN90146 143-67-9 C46H58N4O9.H2SO4 = 909.06 20mg QQ客服:3257982914
    长春碱; Vinblastine CFN90230 865-21-4 C46H58N4O9 = 810.96 20mg QQ客服:2159513211
    脱水长春碱; 3',4'-Anhydrovinblastine CFN90246 38390-45-3 C46H56N4O8 = 792.96 5mg QQ客服:1413575084
    硫酸长春新碱; Vincristine sulfate CFN90400 2068-78-2 C46H58N4O14S = 923.04 20mg QQ客服:1457312923
    长春瑞滨; Vinorelbine CFN90401 71486-22-1 C45H54N4O8 = 778.93 20mg QQ客服:3257982914
    长春地辛; Vindesine CFN90465 53643-48-4 C43H55N5O7 = 753.92 5mg QQ客服:215959384
    环氧长春碱,长春素; Vinleurosine CFN90466 23360-92-1 C46H56N4O9 = 808.95 5mg QQ客服:1457312923
    长春新碱; Vincristine CFN98589 57-22-7 C46H56N4O10 = 824.96 20mg QQ客服:1457312923

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