
羟基马桑毒内酯
Tutin
|
产品编号 |
CFN98289 |
CAS编号 |
2571-22-4 |
分子式 = 分子量 |
C15H18O6 = 294.3 |
产品纯度 |
>=98% |
物理属性 |
Powder |
化合物类型 |
Sesquiterpenoids |
植物来源 |
The herbs of Coriaria nepalensis Wall. |
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用 |
|
产品名称 |
产品编号 |
CAS编号 |
包装 |
QQ客服 |
羟基马桑毒内酯 |
CFN98289 |
2571-22-4 |
1mg |
QQ客服:215959384 |
羟基马桑毒内酯 |
CFN98289 |
2571-22-4 |
5mg |
QQ客服:215959384 |
羟基马桑毒内酯 |
CFN98289 |
2571-22-4 |
10mg |
QQ客服:215959384 |
羟基马桑毒内酯 |
CFN98289 |
2571-22-4 |
20mg |
QQ客服:215959384 |
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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.
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Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.
IF=13.297(2019)PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)PMID: 30417089
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国外学术期刊发表的引用ChemFaces产品的部分文献
Description: |
Tutin in honey, is a plant-derived neurotoxin.
|
In vitro: |
J Nat Prod. 2015 Jun 26;78(6):1363-9. | Sweet Poisons: Honeys Contaminated with Glycosides of the Neurotoxin Tutin.[Pubmed: 25993882] |
Poisonings due to consumption of honeys containing plant toxins have been reported widely. One cause is the neurotoxin Tutin, an oxygenated sesquiterpene picrotoxane, traced back to honeybees (Apis mellifera) collecting honeydew produced by passionvine hoppers (Scolypopa australis) feeding on sap of the poisonous shrub tutu (Coriaria spp.). However, a pharmacokinetic study suggested that unidentified conjugates of Tutin were also present in such honeys.
METHODS AND RESULTS:
We now report the discovery, using ion trap LC-MS, of two Tutin glycosides and their purification and structure determination as 2-(β-d-glucopyranosyl)Tutin (4) and 2-[6'-(α-d-glucopyranosyl)-β-d-glucopyranosyl]Tutin (5). These compounds were used to develop a quantitative triple quadrupole LC-MS method for honey analysis, which showed the presence of Tutin (3.6 ± 0.1 μg/g honey), hyenanchin (19.3 ± 0.5), Tutin glycoside (4) (4.9 ± 0.4), and Tutin diglycoside (5) (4.9 ± 0.1) in one toxic honey. The ratios of 4 and 5 to Tutin varied widely in other Tutin-containing honeys.
CONCLUSIONS:
The glycosidation of Tutin may represent detoxification by one or both of the insects involved in the food chain from plant to honey. |
|
In vivo: |
Food Chem Toxicol. 2014 Oct;72:234-41. | Human pharmacokinetic study of tutin in honey; a plant-derived neurotoxin.[Pubmed: 25084484] | Over the last 150 years a number of people in New Zealand have been incapacitated, hospitalised, or died from eating honey contaminated with Tutin, a plant-derived neurotoxin.
METHODS AND RESULTS:
To investigate the basis of this variability a pharmacokinetic study was undertaken in which 6 healthy males received a single oral dose of Tutin-containing honey giving a Tutin dose of 1.8 μg/kg body weight. The serum concentration-time curve for all volunteers exhibited two discrete peaks with the second and higher level occurring at approximately 15 h post-dose. Two subjects reported mild, transient headache at a time post-dose corresponding to maximum Tutin concentrations. There were no other signs or symptoms typical of Tutin intoxication such as nausea, vomiting, dizziness or seizures. Pharmacokinetic analysis using a two-site absorption model resulted in a good fit to the observed concentration data.
CONCLUSIONS:
A novel analytical method subsequently revealed the presence of glycoside conjugates of Tutin in addition to unconjugated Tutin in honey. These pharmacokinetic data will be important to better define a safe maximum Tutin concentration in honey. |
|
|
1 mg |
5 mg |
10 mg |
20 mg |
25 mg |
1 mM |
3.3979 mL |
16.9895 mL |
33.9789 mL |
67.9579 mL |
84.9473 mL |
5 mM |
0.6796 mL |
3.3979 mL |
6.7958 mL |
13.5916 mL |
16.9895 mL |
10 mM |
0.3398 mL |
1.6989 mL |
3.3979 mL |
6.7958 mL |
8.4947 mL |
50 mM |
0.068 mL |
0.3398 mL |
0.6796 mL |
1.3592 mL |
1.6989 mL |
100 mM |
0.034 mL |
0.1699 mL |
0.3398 mL |
0.6796 mL |
0.8495 mL |
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
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