羟基马桑毒内酯

Tutin

	产品编号	CFN98289
	CAS编号	2571-22-4
	分子式 = 分子量	C₁₅H₁₈O₆ = 294.3
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Sesquiterpenoids
	植物来源	The herbs of Coriaria nepalensis Wall.
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
羟基马桑毒内酯	CFN98289	2571-22-4	1mg	QQ客服：215959384
羟基马桑毒内酯	CFN98289	2571-22-4	5mg	QQ客服：215959384
羟基马桑毒内酯	CFN98289	2571-22-4	10mg	QQ客服：215959384
羟基马桑毒内酯	CFN98289	2571-22-4	20mg	QQ客服：215959384

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

University of Beira Interior (Portugal)

University of Wuerzburg (Germany)

University of Medicine and Pharmacy (Romania)

The Institute of Cancer Research (United Kingdom)

CSIRO - Agriculture Flagship (Australia)

University of Canterbury (New Zealand)

Universidade Federal de Pernambuco (UFPE) (Brazil)

University of Melbourne (Australia)

The Australian National University (Australia)

Cornell University (USA)

Johannes Gutenberg University Mainz (JGU) (Germany)

Heidelberg University (Germany)

Weizmann Institute of Science (Israel)

Centrum Menselijke Erfelijkheid (Belgium)

More...

Description:

Tutin in honey, is a plant-derived neurotoxin.

In vitro:

J Nat Prod. 2015 Jun 26;78(6):1363-9.

Sweet Poisons: Honeys Contaminated with Glycosides of the Neurotoxin Tutin.[Pubmed: 25993882]

Poisonings due to consumption of honeys containing plant toxins have been reported widely. One cause is the neurotoxin Tutin, an oxygenated sesquiterpene picrotoxane, traced back to honeybees (Apis mellifera) collecting honeydew produced by passionvine hoppers (Scolypopa australis) feeding on sap of the poisonous shrub tutu (Coriaria spp.). However, a pharmacokinetic study suggested that unidentified conjugates of Tutin were also present in such honeys.
METHODS AND RESULTS:
We now report the discovery, using ion trap LC-MS, of two Tutin glycosides and their purification and structure determination as 2-(β-d-glucopyranosyl)Tutin (4) and 2-[6'-(α-d-glucopyranosyl)-β-d-glucopyranosyl]Tutin (5). These compounds were used to develop a quantitative triple quadrupole LC-MS method for honey analysis, which showed the presence of Tutin (3.6 ± 0.1 μg/g honey), hyenanchin (19.3 ± 0.5), Tutin glycoside (4) (4.9 ± 0.4), and Tutin diglycoside (5) (4.9 ± 0.1) in one toxic honey. The ratios of 4 and 5 to Tutin varied widely in other Tutin-containing honeys.
CONCLUSIONS:
The glycosidation of Tutin may represent detoxification by one or both of the insects involved in the food chain from plant to honey.

In vivo:

Food Chem Toxicol. 2014 Oct;72:234-41.

Human pharmacokinetic study of tutin in honey; a plant-derived neurotoxin.[Pubmed: 25084484]

Over the last 150 years a number of people in New Zealand have been incapacitated, hospitalised, or died from eating honey contaminated with Tutin, a plant-derived neurotoxin.
METHODS AND RESULTS:
To investigate the basis of this variability a pharmacokinetic study was undertaken in which 6 healthy males received a single oral dose of Tutin-containing honey giving a Tutin dose of 1.8 μg/kg body weight. The serum concentration-time curve for all volunteers exhibited two discrete peaks with the second and higher level occurring at approximately 15 h post-dose. Two subjects reported mild, transient headache at a time post-dose corresponding to maximum Tutin concentrations. There were no other signs or symptoms typical of Tutin intoxication such as nausea, vomiting, dizziness or seizures. Pharmacokinetic analysis using a two-site absorption model resulted in a good fit to the observed concentration data.
CONCLUSIONS:
A novel analytical method subsequently revealed the presence of glycoside conjugates of Tutin in addition to unconjugated Tutin in honey. These pharmacokinetic data will be important to better define a safe maximum Tutin concentration in honey.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
马桑宁内酯; Corianin	CFN98470	35481-77-7	C₁₅H₁₈O₆ = 294.3	5mg	QQ客服：215959384
13-O-乙酰基马桑宁; 13-O-Acetylcorianin	CFN99091	108887-44-1	C₁₇H₂₀O₇ = 336.3	5mg	QQ客服：1413575084
羟基马桑毒内酯; Tutin	CFN98289	2571-22-4	C₁₅H₁₈O₆ = 294.3	5mg	QQ客服：1413575084
2-邻乙酰基羟基马桑毒素; 2-O-Acetyltutin	CFN98329	2749-28-2	C₁₇H₂₀O₇ = 336.3	5mg	QQ客服：2056216494
马桑亭; Coriatin	CFN97480	91653-75-7	C₁₅H₂₀O₆ = 296.3	5mg	QQ客服：1413575084
6-O-乙酰马桑亭; 6-O-Acetylcoriatin	CFN96743	1432063-63-2	C₁₇H₂₂O₇ = 338.35	5mg	QQ客服：215959384
异野葛素; Isohyenanchin	CFN99894	19417-00-6	C₁₅H₂₀O₇ = 312.3	5mg	QQ客服：2159513211

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.3979 mL	16.9895 mL	33.9789 mL	67.9579 mL	84.9473 mL
5 mM	0.6796 mL	3.3979 mL	6.7958 mL	13.5916 mL	16.9895 mL
10 mM	0.3398 mL	1.6989 mL	3.3979 mL	6.7958 mL	8.4947 mL
50 mM	0.068 mL	0.3398 mL	0.6796 mL	1.3592 mL	1.6989 mL
100 mM	0.034 mL	0.1699 mL	0.3398 mL	0.6796 mL	0.8495 mL

羟基马桑毒内酯

Tutin

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