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  • 异野葛素

    Isohyenanchin

    异野葛素
    产品编号 CFN99894
    CAS编号 19417-00-6
    分子式 = 分子量 C15H20O7 = 312.3
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Sesquiterpenoids
    植物来源 The herbs of Coriaria nepalensis Wall.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    异野葛素 CFN99894 19417-00-6 1mg QQ客服:1413575084
    异野葛素 CFN99894 19417-00-6 5mg QQ客服:1413575084
    异野葛素 CFN99894 19417-00-6 10mg QQ客服:1413575084
    异野葛素 CFN99894 19417-00-6 20mg QQ客服:1413575084
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • MTT Agrifood Research Finland (Finland)
  • University of Maryland (USA)
  • University of Toulouse (France)
  • Uniwersytet Gdański (Poland)
  • Sant Gadge Baba Amravati University (India)
  • Leibniz-Institut für Pflanzenbiochemie (IPB) (Germany)
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  • Guangzhou Institutes of Biomedicine and Health (China)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Oncol Rep.2016, 35(3):1356-64
  • Antioxidants (Basel).2022, 11(12):2496.
  • PLoS One.2018, 13(4):e0195642
  • Pharmacogn J.2022, 14(2):350-357
  • Pharmaceuticals (Basel). 2021, 14(10):986.
  • Analytical sci. & Tech2016, 186-193
  • Food and Fermentation Industries2018, 44(371)
  • Food Funct.2022, 13(23):12105-12120.
  • Acta Chromatographica2016, 29(3)
  • J Nat Prod.2017, 80(4):854-863
  • Plant Pathology2022, 10.1111:ppa.13651.
  • J of the Korean Society of Cosmetics and Cosmetology2018, 399-406
  • RSC Adv.2018, 32621-32636
  • Molecules.2021, 26(2):E255.
  • Molecules.2017, 22(12)
  • Neurotoxicology.2022, 91:218-227.
  • J Pharm Biomed Anal.2021, 196:113931.
  • J Nat Sc Biol Med2019, 10(2):149-156
  • Food Chem.2021, 337:128023.
  • J Food Biochem.2021, 45(7):e13774.
  • J of the Korean Society of Food Science and Nutrition2019, 32(2):148-154
  • Molecules.2015, 20(11):20014-30
  • Food Analytical Methods2020, 1-10
  • ...
  • 生物活性
    Description: Isohyenanchin is the potent antagonist of RDLac homo-oligomers, it is also a weak antagonist of ionotropic GABA receptors.
    Targets: GABA Receptor
    In vitro:
    Br. J. Pharmacol., 1996, 119(8):1569-76.
    Actions of picrodendrin antagonists on dieldrin-sensitive and -resistant Drosophila GABA receptors.[Pubmed: 8982503]
    1. A series of terpenoid compounds, recently isolated from Picrodendron baccatum, share a picrotoxane skeleton with picrotoxinin, an antagonist of ionotropic GABA receptors. Referred to as picrodendrins, they inhibit the binding of [35S]-tert-butylbicyclophosphorothionate (TBPS) to rat GABAA receptors.
    METHODS AND RESULTS:
    Hitherto, their effects on GABA receptors have not been investigated electrophysiologically. Under two-electrode voltage-clamp, the actions of picrodendrins and related terpenoids have been assayed on homooligomeric GABA receptors formed by the expression of a Drosophila GABA receptor subunit (RDLac) in Xenopus oocytes. 2. All the terpenoids tested, dose-dependently antagonized currents induced by 30 microM (EC50) GABA. 3. Tutin and its analogues (dihydrotutin and Isohyenanchin) differ in the structure of their axial C4 substituents. Of these compounds, tutin, which bears an isopropenyl group at this carbon atom, was the most potent antagonist of RDLac homo-oligomers, whereas Isohyenanchin, which bears a hydroxyisopropyl group, was the least potent antagonist tested. 4. Picrodendrins differ mainly in the structure of their C9 substituents. The IC50s of picrodendrins ranged from 17 +/- 1.3 nM (picrodendrin-Q) to 1006 +/- 1.3 nM (picrodendrin-O).
    CONCLUSIONS:
    As such, the most potent picrodendrins (Q, A and B) were approximately equipotent with picrotoxinin as antagonists of RDLac homo-oligomers.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.202 mL 16.0102 mL 32.0205 mL 64.041 mL 80.0512 mL
    5 mM 0.6404 mL 3.202 mL 6.4041 mL 12.8082 mL 16.0102 mL
    10 mM 0.3202 mL 1.601 mL 3.202 mL 6.4041 mL 8.0051 mL
    50 mM 0.064 mL 0.3202 mL 0.6404 mL 1.2808 mL 1.601 mL
    100 mM 0.032 mL 0.1601 mL 0.3202 mL 0.6404 mL 0.8005 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    马桑宁内酯; Corianin CFN98470 35481-77-7 C15H18O6 = 294.3 5mg QQ客服:215959384
    13-O-乙酰基马桑宁; 13-O-Acetylcorianin CFN99091 108887-44-1 C17H20O7 = 336.3 5mg QQ客服:1457312923
    羟基马桑毒内酯; Tutin CFN98289 2571-22-4 C15H18O6 = 294.3 5mg QQ客服:215959384
    2-邻乙酰基羟基马桑毒素; 2-O-Acetyltutin CFN98329 2749-28-2 C17H20O7 = 336.3 5mg QQ客服:215959384
    马桑亭; Coriatin CFN97480 91653-75-7 C15H20O6 = 296.3 5mg QQ客服:215959384
    6-O-乙酰马桑亭; 6-O-Acetylcoriatin CFN96743 1432063-63-2 C17H22O7 = 338.35 5mg QQ客服:1413575084
    异野葛素; Isohyenanchin CFN99894 19417-00-6 C15H20O7 = 312.3 5mg QQ客服:2159513211

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