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  • 款冬酮

    Tussilagone

    款冬酮
    产品编号 CFN90629
    CAS编号 104012-37-5
    分子式 = 分子量 C23H34O5 = 390.51
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Sesquiterpenoids
    植物来源 The flowers of Tussilago farfara.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    款冬酮 CFN90629 104012-37-5 10mg QQ客服:215959384
    款冬酮 CFN90629 104012-37-5 20mg QQ客服:215959384
    款冬酮 CFN90629 104012-37-5 50mg QQ客服:215959384
    款冬酮 CFN90629 104012-37-5 100mg QQ客服:215959384
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Shanghai Institute of Biochemistry and Cell Biology (China)
  • Universidad Veracuzana (Mexico)
  • Heinrich-Heine-University Düsseldorf (Germany)
  • Istanbul University (Turkey)
  • Universidad Industrial de Santander (Colombia)
  • Universit?t Basel (Switzerland)
  • Funda??o Universitária de Desenvolvimento (Brazil)
  • Universita' Degli Studi Di Cagliari (Italy)
  • Shanghai University of TCM (China)
  • University of Sao Paulo (Brazil)
  • Kitasato University (Japan)
  • Johannes Gutenberg University Mainz (JGU) (Germany)
  • Lodz University of Technology (Poland)
  • University of Otago (New Zealand)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • J Ethnopharmacol.2017, 196:75-83
  • Food Chem.2020, 313:126079
  • Plant Physiol Biochem.2023, 203:108073.
  • J Ethnopharmacol.2020, 269:113752.
  • Biochem Biophys Res Commun.2018, 495(1):1271-1277
  • Ind Crops Prod.2014, 62:173-178
  • Histol Histopathol.2022, 18518.
  • Bio-protocol2018, 9(14):e3301
  • Food Chem.2022, 378:131975.
  • Phytomedicine.2021, 93:153796.
  • Int J Mol Sci.2022, 23(11):6172.
  • Tea Res. Ins. Of China2017, 1-12
  • Institute of Food Science & Technology2021, 45(9).
  • Front Microbiol.2023, 14:1232039.
  • Molecules2022, 27(9):2613.
  • Natural Product Communications2020, doi: 10.1177.
  • J Chromatogr B Analyt Technol Biomed Life Sci. 2017, 1064:115-123
  • Exp Parasitol.2015, 153:160-4
  • Int J Med Sci.2020, 17(5):626-631
  • Separations2023, 10(11), 567;
  • Food Chem.2018, 262:78-85
  • Chung Shan Medical University2020, US20200323790A1
  • Neurochem Int.2020, 133:104629
  • ...
  • 生物活性
    Description: Tussilagone has anti-cancer, anti-oxidant and anti-inflammatory activities. Tussilagone inhibits dendritic cell function through the induction of heme oxygenase-1; it has potential treatment of neuro-inflammatory diseases through the inhibition of overproduction of nitric oxide and prostaglandin E(2).
    Targets: NF-kB | HO-1 | TLR | IkB | Wnt/β-catenin | c-Myc | NO | NOS | COX | TNF-α | MAPK | p65 | IKK
    In vitro:
    Biochem Biophys Res Commun. 2014 Jan 3;443(1):132-7.
    Tussilagone suppresses colon cancer cell proliferation by promoting the degradation of β-catenin.[Pubmed: 24269588]
    Abnormal activation of the Wnt/β-catenin signaling pathway frequently induces colon cancer progression.
    METHODS AND RESULTS:
    In the present study, we identified tussilagone (TSL), a compound isolated from the flower buds of Tussilago farfara, as an inhibitor on β-catenin dependent Wnt pathway. TSL suppressed β-catenin/T-cell factor transcriptional activity and down-regulated β-catenin level both in cytoplasm and nuclei of HEK293 reporter cells when they were stimulated by Wnt3a or activated by an inhibitor of glycogen synthase kinase-3β. Since the mRNA level was not changed by TSL, proteasomal degradation might be responsible for the decreased level of β-catenin. In SW480 and HCT116 colon cancer cell lines, TSL suppressed the β-catenin activity and also decreased the expression of cyclin D1 and c-myc, representative target genes of the Wnt/β-catenin signaling pathway, and consequently inhibited the proliferation of colon cancer cells.
    CONCLUSIONS:
    Taken together, TSL might be a potential chemotherapeutic agent for the prevention and treatment of human colon cancer.
    Arch Pharm Res. 2008 May;31(5):645-52.
    Suppression of inducible nitric oxide synthase and cyclooxygenase-2 expression by tussilagone from Farfarae flos in BV-2 microglial cells.[Pubmed: 18481023]
    Activated microglia produce diverse neurotoxic factors such as nitric oxide (NO) and prostaglandin E(2) (PGE(2)) that may cause neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease.
    METHODS AND RESULTS:
    From the EtOAc soluble fraction of Farfarae flos (Tussilago farfara), we purified tussilagone as a bioactive compound by monitoring the inhibitory potential of NO production in activated microglia through the purification procedures. Tussilagone showed dose-dependent inhibition of NO and PGE(2) production in LPS-activated microglia with IC(50) values of 8.67 microM and 14.1 microM, respectively. It suppressed the expression of protein and mRNA of inducible nitric oxide synthase and cyclooxygenase-2 through the inhibition of 1-kappaBalpha degradation and nuclear translocation of p65 subunit of NF-kappaB.
    CONCLUSIONS:
    Therefore tussilagone from Farfarae flos may have therapeutic potential in the treatment of neuro-inflammatory diseases through the inhibition of overproduction of NO and PGE(2).
    Chem Biol Interact . 2018 Oct 1;294:74-80.
    Tussilagone, a major active component in Tussilago farfara, ameliorates inflammatory responses in dextran sulphate sodium-induced murine colitis[Pubmed: 30142311]
    Abstract Inflammatory bowel disease (IBD) is a chronically relapsing inflammatory disorder of the gastrointestinal tract. Current IBD treatments are associated with poor tolerability and insufficient therapeutic efficacy, prompting the need for alternative therapeutic approaches. Recent advances suggest promising interventions based on a number of phytochemicals. Herein, we explored the beneficial effects of tussilagone, a major component of Tussilago farfara, in mice subjected to acute colitis induced by dextran sulfate sodium (DSS). Treatment with tussilagone resulted in a significant protective effect against DSS-induced acute colitis in mice via amelioration of weight loss, and attenuation of colonic inflammatory damage. Additionally, the expression of tumor necrosis factor-α and interleukin-6 and the activity of myeloperoxidase in colonic tissues were significantly reduced in tussilagone-treated mice. Furthermore, immunohistochemical analysis revealed that tussilagone treatment reduced the numbers of nuclear factor-kappa B (NF-κB) and increased the numbers of nuclear factor erythroid 2-related factor 2 (Nrf2) in nuclei of colonic tissues. Taken together, tussilagone treatment attenuated DSS-induced colitis in mice through inhibiting the activation of NF-κB and inducing Nrf2 pathways, indicating that tussilagone is a potent therapeutic candidate for treatment of intestinal inflammation.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.5608 mL 12.8038 mL 25.6075 mL 51.2151 mL 64.0188 mL
    5 mM 0.5122 mL 2.5608 mL 5.1215 mL 10.243 mL 12.8038 mL
    10 mM 0.2561 mL 1.2804 mL 2.5608 mL 5.1215 mL 6.4019 mL
    50 mM 0.0512 mL 0.2561 mL 0.5122 mL 1.0243 mL 1.2804 mL
    100 mM 0.0256 mL 0.128 mL 0.2561 mL 0.5122 mL 0.6402 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    Ylangenyl acetate; Ylangenyl acetate CFN96414 90039-63-7 C17H26O2 = 262.39 5mg QQ客服:1457312923
    Ylangenol; Ylangenol CFN96415 41610-69-9 C15H24O = 220.35 5mg QQ客服:2056216494
    10(14)-杜松萜烯-4,5-二醇; 10(14)-Cadinene-4,5-diol CFN97146 672336-50-4 C15H26O2 = 238.4 5mg QQ客服:215959384
    异水菖蒲二醇; Isocalamendiol CFN98278 25330-21-6 C15H26O2 = 238.4 5mg QQ客服:2056216494
    10-O-乙酰异水菖蒲二醇; 10-O-Acetylisocalamendiol CFN96767 1432064-69-1 C17H28O3 = 280.40 5mg QQ客服:3257982914
    4-杜松萜烯-7-醇; 4-Cadinen-7-ol CFN98081 217650-27-6 C15H26O = 222.4 5mg QQ客服:1457312923
    (-)-Cadin-4,10(15)-dien-11-oic acid; (-)-Cadin-4,10(15)-dien-11-oic acid CFN95246 1124353-23-6 C15H22O2 = 234.3 5mg QQ客服:1457312923
    3-乙酰氧基-4-杜松萜烯-8-酮; 3-Acetoxy-4-cadinen-8-one CFN97485 923950-05-4 C17H26O3 = 278.4 5mg QQ客服:1413575084
    9-酮-泽兰素; 9-Oxoageraphorone CFN99071 105181-06-4 C15H22O2 = 234.3 5mg QQ客服:2159513211
    去氢白菖烯-3,7-二醇; 1,3,5-Cadinatriene-3,8-diol CFN97514 941227-27-6 C15H22O2 = 234.3 5mg QQ客服:1413575084

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