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  • 络石苷

    Tracheloside

    络石苷
    产品编号 CFN90597
    CAS编号 33464-71-0
    分子式 = 分子量 C27H34O12 = 550.2
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Lignans
    植物来源 The herbs of Trachelospermum jasminoides (Lindl.) Lem.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
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    产品名称 产品编号 CAS编号 包装 QQ客服
    络石苷 CFN90597 33464-71-0 10mg QQ客服:2056216494
    络石苷 CFN90597 33464-71-0 20mg QQ客服:2056216494
    络石苷 CFN90597 33464-71-0 50mg QQ客服:2056216494
    络石苷 CFN90597 33464-71-0 100mg QQ客服:2056216494
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • PLoS One.2017, 12(8):e0181191
  • J Ethnopharmacol.2017, 197:157-164
  • Antioxidants (Basel).2021, 10(11): 1802.
  • GxABT2022, 2268.2:15515.
  • J Pharm Anal.2016, 6(6):363-373
  • FEMS Microbiol Lett.2017, 364(11)
  • J Microbiol Biotechnol.2020, 30(2):178-186.
  • BMC Complement Altern Med.2014, 14:352
  • Oncol Rep.2016, 35(3):1356-64
  • PLoS One.2021, 16(6):e0248479.
  • Food Sci Nutr.2023, 11(9):5532-5542.
  • Plants (Basel).2021, 10(2):278.
  • Br J Pharmacol.2018, 175(6):902-923
  • Molecules.2019, 24(21):E3834
  • Molecules 2022, 27(3),1047.
  • Saudi Pharm J2020, 10.1016
  • Int. J. of Food Properties2017, S108-S118
  • Revista Brasileira de Farmacognosia2021, 31:794-804.
  • J Nat Prod.2015, 78(6):1339-4
  • Sci Rep. 2017, 8207(7)
  • Fitoterapia.2022, 105141.
  • Sci Rep. 2017, 12953(7)
  • Exp Neurobiol.2018, 27(3):200-209
  • ...
  • 生物活性
    Description: Tracheloside significantly decreases the activity of alkaline phosphatase (AP), an estrogen-inducible marker enzyme, with an IC(50) value of 0.31 microg/ml, a level of inhibition comparable to that of tamoxifen (IC(50) = 0.43 microg/ml).
    Targets: Estrogen receptor | Progestogen receptor
    In vitro:
    Biosci Biotechnol Biochem. 2006 Nov;70(11):2783-5.
    An anti-estrogenic lignan glycoside, tracheloside, from seeds of Carthamus tinctorius.[Pubmed: 17090940]
    The lignan glycoside, tracheloside, was isolated from seeds of Carthamus tinctorius (Compositae) as an anti-estrogenic principle against cultured Ishikawa cells by employing a bioassay-linked HPLC-ELSD method.
    METHODS AND RESULTS:
    Tracheloside significantly decreased the activity of alkaline phosphatase (AP), an estrogen-inducible marker enzyme, with an IC(50) value of 0.31 microg/ml, a level of inhibition comparable to that of tamoxifen (IC(50) = 0.43 microg/ml).
    Evid Based Complement Alternat Med . 2018 Jul 26;2018:4580627.
    Promotion of Keratinocyte Proliferation by Tracheloside through ERK1/2 Stimulation[Pubmed: 30147732]
    Abstract Cell migration and proliferation are important for proper wound healing after skin injury. Recent studies have shown that compounds from plants could promote cell migration and proliferation. Tracheloside, which is a plant lignan, has been found to promote the growth of HaCaT cells over 40% compared to other compounds tested based on a cell proliferation assay. An in vitro scratch assay confirmed the healing activity of tracheloside (more than 2-fold increased healing activity after 24 hours of treatment compared with the control) and revealed that this activity is better than that of allantoin (1.2-fold increased after 24 hours of treatment compared with the control), a positive control. With western blot results, wound healing with tracheloside occurred through the phosphorylation of ERK1/2. Therefore, tracheloside is a good candidate to promote wound healing and could be developed as a therapeutic agent for wound treatment or used as a leading compound with higher activity.
    In vivo:
    Cancer Lett. 2003 Oct 28;200(2):133-9.
    Lack of significant inhibitory effects of a plant lignan tracheloside on 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-induced mammary carcinogenesis in female Sprague-Dawley rats.[Pubmed: 14568166]
    Tracheloside, one of the plant lignans which can be extracted from the debris after safflower oil is produced from the seeds of Carthamus tinctorious, is an analogue of another plant lignan, arctiin, the side-chain C-2 of the five-membered ring being changed from a hydrogen to a hydroxyl group. We have already demonstrated that arctiin has chemopreventive effect on mammary carcinogenesis. Therefore, chemopreventive effects of tracheloside on the initiation or post-initiation period of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-induced mammary carcinogenesis in female rats were examined.
    METHODS AND RESULTS:
    For initiation, female Sprague-Dawley (SD) rats at the 6 weeks of age were given intragastric administrations of 100 mg/kg body weight of PhIP once a week for 8 weeks. The animals were treated with 0.2 or 0.02% tracheloside during or after this carcinogen exposure. Control rats were fed basal diet with PhIP initiation or 0.2% tracheloside or basal diet alone without initiation throughout the experimental period. All surviving animals were necropsied at the week 52 of administration. There were no clear treatment-related changes with statistical significance in all parameters for mammary carcinomas measured in this experiment.
    CONCLUSIONS:
    These results indicate that tracheloside may not exert significant effects on PhIP-induced mammary carcinogenesis at least under the present experiment condition.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.8175 mL 9.0876 mL 18.1752 mL 36.3504 mL 45.438 mL
    5 mM 0.3635 mL 1.8175 mL 3.635 mL 7.2701 mL 9.0876 mL
    10 mM 0.1818 mL 0.9088 mL 1.8175 mL 3.635 mL 4.5438 mL
    50 mM 0.0364 mL 0.1818 mL 0.3635 mL 0.727 mL 0.9088 mL
    100 mM 0.0182 mL 0.0909 mL 0.1818 mL 0.3635 mL 0.4544 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    异牛蒡酚A; Isolappaol A CFN95224 131400-96-9 C30H32O9 = 536.6 10mg QQ客服:1457312923
    牛蒡酚B; Lappaol B CFN95242 62359-60-8 C31H34O9 = 550.6 10mg QQ客服:1457312923
    牛蒡酚C; Lappaol C CFN95068 64855-00-1 C30H34O10 = 554.6 10mg QQ客服:215959384
    异牛蒡酚C; Isolappaol C CFN95225 929905-15-7 C30H34O10 = 554.6 10mg QQ客服:1457312923
    牛蒡酚F; Lappaol F CFN95069 69394-17-8 C40H42O12 = 714.8 10mg QQ客服:2056216494
    (+)-罗汉松树脂酚 ; (+)-Matairesinol CFN96715 148409-36-3 C20H22O6 = 358.39 5mg QQ客服:2056216494
    Isosalicifolin; Isosalicifolin CFN96234 156974-99-1 C20H20O6 = 356.4 5mg QQ客服:3257982914
    去甲络石甙元; Nortrachelogenin CFN98454 34444-37-6 C20H22O7 = 374.4 10mg QQ客服:2159513211
    荛花酚 ; (+)-Nortrachelogenin CFN96714 61521-74-2 C20H22O7 = 374.38 5mg QQ客服:1413575084
    (7R)-甲氧基-8-表-罗汉松树脂酚 ; (7R)-Methoxy-8-epi-matairesinol CFN89300 198827-23-5 C21H24O7 = 388.41 5mg QQ客服:1457312923

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