| Description: |
Tormentic acid has anticancer, anti-inflammatory, anti-atherogenic , anti-allodynic, and hepatoprotective properties, it can inhibit markedly the neuropathic allodynia induced by partial ligation of the sciatic nerve. Tormentic acid potently inhibits the production of nitric oxide (NO) in RAW 264.7 cells, also suppresses the LPS-stimulated degradation and phosphorylation of inhibitor of kappa B-α (IκB-α), suggests that the anti-inflammatory activity of TA is associated with the down-regulation of iNOS, COX-2, and TNF-α through the negative regulation of the NF-κB pathway in RAW 264.7 cells.
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| In vivo: |
| Int Immunopharmacol. 2014 Apr;19(2):365-72. | | Protective effect of tormentic acid from Potentilla chinensis against lipopolysaccharide/D-galactosamine induced fulminant hepatic failure in mice.[Pubmed: 24560903] | A compound was isolated from Potentilla chinensis, and it was identified as Tormentic acid (TA) based on its physicochemical properties and spectral data.
METHODS AND RESULTS:
The hepatoprotective effect of Tormentic acid was evaluated using an acute liver failure model induced by lipopolysaccharide (LPS)/D-galactosamine (D-GalN).
The results revealed that Tormentic acid significantly prevented LPS/D-GalN-induced fulminant hepatic failure, as evidenced by the decrease in serum aminotransferase and total bilirubin activities and the attenuation of histopathological changes. Tormentic acid alleviated the pro-inflammatory cytokines including TNF-α and NO/iNOS by inhibiting nuclear factor-κB (NF-κB) activity. Moreover, Tormentic acid strongly inhibited lipid peroxidation, recruited the anti-oxidative defense system, and increased HO-1 activity. In addition, Tormentic acid significantly attenuated increases in TUNEL-positive hepatocytes through decreasing the levels of cytochrome c, as well as caspases-3, 8 and 9, while augmenting the expression of Bcl-2.
CONCLUSIONS:
In conclusion, Tormentic acid protects hepatocytes against LPS/D-GalN-induced injury by blocking NF-κB signaling pathway for anti-inflammatory response and attenuating hepatocellular apoptosis. Consequently, Tormentic acid is a potential agent for preventing acute liver injury and may be a major bioactive ingredient of Potentilla chinensis. | | Eur J Pharmacol. 2002 Oct 25;453(2-3):203-8. | | Anti-allodynic action of the tormentic acid, a triterpene isolated from plant, against neuropathic and inflammatory persistent pain in mice.[Pubmed: 12398905] |
METHODS AND RESULTS:
The inhibition observed was 82+/-9% and 100+/-11%, respectively. Interestingly, Tormentic acid did not inhibit paw oedema formation following Complete Freund's Adjuvant plantar injection. Tormentic acid (30 mg/kg, p.o.) and gabapentin (70 mg/kg, p.o.), given twice a day, inhibited markedly the neuropathic allodynia induced by partial ligation of the sciatic nerve, with inhibition of 91+/-19% and 71+/-16%, respectively. The anti-allodynic action of Tormentic acid was not associated with impairment of the motor activity of the animals.
CONCLUSIONS:
Together, the present results indicate that Tormentic acid or its derivatives might be of potential interest in the development of new clinically relevant drugs for the management of persistent neuropathic and inflammatory allodynia. |
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