四氢鸭脚木碱
Tetrahydroalstonine
|
|
产品编号 |
CFN97109 |
| CAS编号 |
6474-90-4 |
| 分子式 = 分子量 |
C21H24N2O3 = 352.4 |
| 产品纯度 |
>=98% |
| 物理属性 |
Solid |
| 化合物类型 |
Alkaloids |
| 植物来源 |
The herbs of Uncaria rhynchophylla (Miq.) Miq. ex Havil. |
| ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用 |
|
| 产品名称 |
产品编号 |
CAS编号 |
包装 |
QQ客服 |
| 四氢鸭脚木碱 |
CFN97109 |
6474-90-4 |
1mg |
QQ客服：2159513211 |
| 四氢鸭脚木碱 |
CFN97109 |
6474-90-4 |
5mg |
QQ客服：2159513211 |
| 四氢鸭脚木碱 |
CFN97109 |
6474-90-4 |
10mg |
QQ客服：2159513211 |
| 四氢鸭脚木碱 |
CFN97109 |
6474-90-4 |
20mg |
QQ客服：2159513211 |
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ChemFaces的产品在许多优秀和顶级科学期刊中被引用
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.
IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)PMID: 30417089
我们的产品现已经出口到下面的研究机构与大学，并且还在增涨
Leibniz Institute of Plant Biochemistry (Germany)
University of Oslo (Norway)
Centralised Purchases Unit (CPU), B.I.T.S (India)
Charles Sturt University (Denmark)
VIB Department of Plant Systems Biology, UGent (PSB) (Belgium)
Centrum Menselijke Erfelijkheid (Belgium)
Yale University (USA)
University of Toronto (Canada)
Universita' Degli Studi Di Cagliari (Italy)
Chungnam National University (Korea)
National Cancer Center Research Institute (Japan)
Semmelweis Unicersity (Hungary)
National Cancer Institute (USA)
University of Wollongong (Australia)
More...
国外学术期刊发表的引用ChemFaces产品的部分文献
| Description: |
Tetrahydroalstonine and Raubasine preferentially block the pressor responses of post-synaptic alpha-adrenergic receptor activation due to exogenous and endogenouse noradrenaline, respectively. |
| Targets: |
Adrenergic Receptor |
| In vivo: |
| J Pharmacol. 1985 Oct-Dec;16(4):412-20. | | Differential inhibition of raubasine and tetrahydroalstonine on the vasopressor response to sympathetic nervous stimulation and intravenous noradrenaline in the pithed rat[Pubmed: 2869187] | The effects of raubasine and tetrahydroalstonine (THA) on the vasopressor response to sympathetic nerve stimulation and to i.v. administration of noradrenaline were studied in the pithed rat to ascertain whether raubasine and THA would preferentially block pressor responses due to exogenous versus endogenous noradrenaline alpha-adrenergic receptor activation.
METHODS AND RESULTS:
Raubasine (0.5 to 4 mg/kg i.v.) was more effective in blocking the response due to sympathetic nerve stimulation than that due to i.v. noradrenaline. On the other hand THA (0.5 to 4 mg/kg i.v.) produced greater inhibition of the i.v. noradrenaline response than the sympathetic nerve stimulation response. THA (0.5, 1, 2 mg/kg i.v.) enhanced the nerve stimulation response, while at the 4 mg/kg dose the response was slightly reduced. This may be explained by a preferential block by THA at low doses, of presynaptic alpha 2-adrenoceptors. In pithed rat raubasine and THA showed dose-related blocking effects on the pressor response of phenylephrine and B-HT 933, respectively. This suggest that raubasine preferentially blocks alpha-1 and THA alpha 2-adrenoceptors.
CONCLUSIONS:
The results suggest that raubasine and THA preferentially block the pressor responses of post-synaptic alpha-adrenergic receptor activation due to endogenous and exogenous noradrenaline, respectively. |
|
|
1 mg |
5 mg |
10 mg |
20 mg |
25 mg |
| 1 mM |
2.8377 mL |
14.1884 mL |
28.3768 mL |
56.7537 mL |
70.9421 mL |
| 5 mM |
0.5675 mL |
2.8377 mL |
5.6754 mL |
11.3507 mL |
14.1884 mL |
| 10 mM |
0.2838 mL |
1.4188 mL |
2.8377 mL |
5.6754 mL |
7.0942 mL |
| 50 mM |
0.0568 mL |
0.2838 mL |
0.5675 mL |
1.1351 mL |
1.4188 mL |
| 100 mM |
0.0284 mL |
0.1419 mL |
0.2838 mL |
0.5675 mL |
0.7094 mL |
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
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