| Description: |
α-Terpineol possesses antifungal activity against Trichophyton mentagrophytes, it also exhibits strong antimicrobial activity against periodontopathic and cariogenic bacteria. α-Terpineol shows anticonvulsant, and anti-inflammatory activities, it inhibits the gene expression of the IL-6 receptor. |
| Targets: |
IL Receptor | Antifection |
| In vitro: |
| Fitoterapia. 2009 Jul;80(5):290-6. | | Effect of citral, eugenol, nerolidol and alpha-terpineol on the ultrastructural changes of Trichophyton mentagrophytes.[Pubmed: 19345255 ] | The antifungal effects of citral, eugenol, nerolidol and alpha-terpineol on Trichophyton mentagrophytes were investigated.
METHODS AND RESULTS:
Citral over 0.1 mg/ml strongly inhibited the hyphal growth of T. mentagrophytes, and the antifungal activity of alpha-terpineol was less effective. The morphological changes of the fungus exposed to the terpenes were observed by electron microscopy. The hyphae were distorted and collapsed at 0.2, 0.4 and 1 mg/ml of eugenol, nerolidol and alpha-terpineol respectively, and cell membrane and organelles were irreversibly damaged at 0.2 mg/ml citral.
CONCLUSIONS:
These suggested that four terpenes possess antifungal activity against T. mentagrophytes, and the activity might lead to irreversible cellular disruption. | | Anaerobe. 2012 Jun;18(3):369-72. | | Antimicrobial effect of linalool and α-terpineol against periodontopathic and cariogenic bacteria.[Pubmed: 22537719 ] |
METHODS AND RESULTS:
Linalool and α-terpineol exhibited strong antimicrobial activity against periodontopathic and cariogenic bacteria. However, their concentration should be kept below 0.4 mg/ml if they are to be used as components of toothpaste or gargling solution.
CONCLUSIONS:
Moreover, other compounds with antimicrobial activity against periodontopathic and cariogenic bacteria should be used in combination. |
|
| In vivo: |
| Pharmaceutical Biology, 2007 , 45 (1) :69-70. | | Evolution of the Anticonvulsant Activity of α-Terpineol[Reference: WebLink] | α-Terpineol, a monoterpenoid alcohol, was investigated for its anticonvulsant activity.
METHODS AND RESULTS:
This compound increased the latency to convulsions induced by pentylenetetrazole at doses of 100 and 200 mg/kg and decreased the incidence of hindlimb extension produced by MES in a dose-related manner at doses of 200 and 400 mg/kg. |
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