丹参酮IIA-磺酸钠

Tanshinone IIA-sulfonic sodium

	产品编号	CFN90399
	CAS编号	69659-80-9
	分子式 = 分子量	C₁₉H₁₇O₆S.Na = 396.39
	产品纯度	>=98%
	物理属性	Red powder
	化合物类型	Diterpenoids
	植物来源	The roots of Salvia miltiorrhiza
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产品名称	产品编号	CAS编号	包装	QQ客服
丹参酮IIA-磺酸钠	CFN90399	69659-80-9	10mg	QQ客服：215959384
丹参酮IIA-磺酸钠	CFN90399	69659-80-9	20mg	QQ客服：215959384
丹参酮IIA-磺酸钠	CFN90399	69659-80-9	50mg	QQ客服：215959384
丹参酮IIA-磺酸钠	CFN90399	69659-80-9	100mg	QQ客服：215959384

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Description:

Tanshinone IIA sulfonate (sodium) is a water-soluble derivative of tanshinone IIA, which acts as an inhibitor of store-operated Ca2+ entry (SOCE), and is used to treat cardiovascular disorders.Sodium tanshinone IIA sulfonate pretreatment reduces infarct size and improves cardiac function in an ischemia-reperfusion-induced rat myocardial injury model via activation of Akt/FOXO3A/Bim-mediated signal pathway.

Targets:

Akt | FOXO3A | Bim | Calcium Channel

In vitro:

Food Chem Toxicol. 2009 Jul;47(7):1538-44.

Tanshinone IIA sodium sulfonate protects against cardiotoxicity induced by doxorubicin in vitro and in vivo.[Pubmed: 19358873 ]

Although doxorubicin (DXR) is an effective antineoplastic agent; the serious cardiotoxicity mediated by the production of reactive oxygen species has remained a considerable clinical problem. Our hypothesis is that Tanshinone IIA-sulfonic sodium (TSNIIA-SS), which holds significant affects on cardioprotection in clinic, protects against DXR-induced cardiotoxicity.
METHODS AND RESULTS:
In vitro investigation on H9c2 cell line, as well as in vivo study in animal model of DXR-induced chronic cardiomyopathy were performed. TSNIIA-SS significantly increased cell viability and ameliorated apoptosis of DXR-injured H9c2 cells using CCK-8 assay and Hoechst 33342 stain respectively. Furthermore, the cardio-protective effects of TSNIIA-SS were confirmed with decreasing ST-interval and QRS interval by electrocardiography (ECG); improving appearance of myocardium with haematoxylin and eosin (H&E) stain; increasing myocardial tensile strength using tension to rupture (TTR) assay and decreasing fibrosis through picric-sirius red staining comparing with those receiving DXR alone.
CONCLUSIONS:
These data have provided the considerable evidences that TSNIIA-SS is a protective agent against DXR-induced cardiac injury.

In vivo:

《Strait Pharmaceutical Journal》 2010-05

Influence of tanshinone on glutamic acid content in spinal cord and serum in a rat model of spinal cord ischemia/reperfusion injury[Reference: WebLink]

To explore the interventional effect of tanshinone on glutamic acid content in spinal cord and in serum and neurological function in a rat model of spinal cord ischemia/reperfusion injury.
METHODS AND RESULTS:
A total of 88 Sprague Dawley rats were randomly divided into a sham operation(n=8),model(n=40),and tanshinone(n=40) groups.Abdominal aorta occlusion was performed along the right renal arterial root using a Scoville-Lewis clamp to induce spinal cord ischemia.Blood flow was recovered 30 minutes following occlusion to establish models of spinal cord ischemia/reperfusion injury.Abdominal aorta occlusion was not performed in the sham operation group.An intraperitoneal injection of Tanshinone IIA-sulfonic sodium solution was administered to rats in the tanshinone group,preoperatively.In addition,rats in the sham operation and model groups were treated with an intraperitoneal injection of the same concentration of saline,preoperatively.Tirty minutes after ischemia,rats in the model and tanshinone groups were observed at 30min,hour1,4,8,and 12 following perfusion,with eight rats for each time point.After cutting the spinal cord and drawing the blood from inferior vena cava at each time point we detected glutamic acid content in spinal cord and glutamic acid content in serum.At hour 4,8,and 12 following perfusion,evaluated neurological fuction using Tarlov method in model and tanshinone groups. All 88 rats were included in the final analysis.Glutamic acid content in spinal and serum of model and tanshinone groups rose ischemia/reperfusion injury 30min later,reached a peak 4 hours after reperfusion,fall-off thenceforth,and put back 12 hours after reperfusion.
CONCLUSIONS:
Tanshinone could reduce glutamic acid content in spinal cord and protected neurological function in a rat model of spinal cord ischemia/reperfusion injury.

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.5228 mL	12.6138 mL	25.2277 mL	50.4554 mL	63.0692 mL
5 mM	0.5046 mL	2.5228 mL	5.0455 mL	10.0911 mL	12.6138 mL
10 mM	0.2523 mL	1.2614 mL	2.5228 mL	5.0455 mL	6.3069 mL
50 mM	0.0505 mL	0.2523 mL	0.5046 mL	1.0091 mL	1.2614 mL
100 mM	0.0252 mL	0.1261 mL	0.2523 mL	0.5046 mL	0.6307 mL

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丹参酮IIA-磺酸钠

Tanshinone IIA-sulfonic sodium

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