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  • 根薯酮内酯B

    Taccalonolide B

    根薯酮内酯B
    产品编号 CFN90602
    CAS编号 108885-69-4
    分子式 = 分子量 C34H44O13 = 660.71
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Steroids
    植物来源 The rhizomes of Schizocapsa plantaginea Hance.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    根薯酮内酯B CFN90602 108885-69-4 1mg QQ客服:1413575084
    根薯酮内酯B CFN90602 108885-69-4 5mg QQ客服:1413575084
    根薯酮内酯B CFN90602 108885-69-4 10mg QQ客服:1413575084
    根薯酮内酯B CFN90602 108885-69-4 20mg QQ客服:1413575084
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Complutense University of Madrid (Spain)
  • Universidad de Ciencias y Artes de Chiapas (Mexico)
  • Texas A&M University (USA)
  • University of Perugia (Italy)
  • University of Minnesota (USA)
  • Korea Food Research Institute(KFRI) (Korea)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Front Microbiol.2021, 12:736780.
  • Molecules.2019, 24(16):E2985
  • Front Nutr.2021, 8: 687851.
  • Antioxidants2022, 11(2),234.
  • Chemistry of Natural Compounds2018, 204-206
  • Plant Cell,Tissue & Organ Culture2016, 127(1):115-121
  • Int J Mol Med.2020, 45(5):1514-1524.
  • J Pharm Biomed Anal2016, 118:183-194
  • Nutr Metab (Lond).2019, 16:31
  • Toxicol In Vitro.2022, 81:105346.
  • Green Chemistry2021, ISSUE 2.
  • Sci Rep.2021, 11(1):14180.
  • J Chromatogr B Analyt Technol Biomed Life Sci.2018, 1080:27-36
  • Front Pharmacol.2022, 13:806869.
  • Int J Mol Sci.2022, 23(11):6104.
  • Evid Based Complement Alternat Med.2020, 2020:9416962.
  • Int J Mol Sci.2021, 22(16):8641.
  • Ulm University Medical Center2020, doi: 10.18725.
  • ACS Chem Biol.2019, 14(5):873-881
  • Molecules.2020, 25(17):3783.
  • Molecules.2019, 24(22):E4022
  • BMC Complement Altern Med.2014, 14:352
  • Vietnam Journal of Science2022, 64(2), 69-75.
  • ...
  • 生物活性
    Description: Taccalonolide B displays microtubule stabilizing activity.Several taccalonolides have in vitro antitrypanosomal activity against Trypanosoma brucei brucei and EC50 values for the isolated compounds were from 0.79 ug/mL.
    Targets: Antifection
    In vitro:
    J. Am. Chem. Soc., 2011, 133 (47), pp 19064–19067
    Potent Taccalonolides, AF and AJ, Inform Significant Structure–Activity Relationships and Tubulin as the Binding Site of These Microtubule Stabilizers[Reference: WebLink]
    The taccalonolides are a class of microtubule stabilizing agents isolated from plants of the genus Tacca. In efforts to define their structure–activity relationships, we isolated five new taccalonolides, AC–AF and H2, from one fraction of an ethanol extract of Tacca plantaginea.
    METHODS AND RESULTS:
    The structures were elucidated using a combination of spectroscopic methods, including 1D and 2D NMR and HR-ESI-MS. Taccalonolide AJ, an epoxidation product of taccalonolide B, was generated by semisynthesis. Five of these taccalonolides demonstrated cellular microtubule-stabilizing activities and antiproliferative actions against cancer cells, with taccalonolide AJ exhibiting the highest potency with an IC50 value of 4.2 nM. The range of potencies of these compounds, from 4.2 nM to >50 μM, for the first time provides the opportunity to identify specific structural moieties crucial for potent biological activities as well as those that impede optimal cellular effects. In mechanistic assays, taccalonolides AF and AJ stimulated the polymerization of purified tubulin, an activity that had not previously been observed for taccalonolides A and B, providing the first evidence that this class of microtubule stabilizers can interact directly with tubulin/microtubules. Taccalonolides AF and AJ were able to enhance tubulin polymerization to the same extent as paclitaxel but exhibited a distinct kinetic profile, suggesting a distinct binding mode or the possibility of a new binding site.
    CONCLUSIONS:
    The potencies of taccalonolides AF and AJ and their direct interaction with tubulin, together with the previous excellent in vivo antitumor activity of this class, reveal the potential of the taccalonolides as new anticancer agents.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.5135 mL 7.5676 mL 15.1352 mL 30.2705 mL 37.8381 mL
    5 mM 0.3027 mL 1.5135 mL 3.027 mL 6.0541 mL 7.5676 mL
    10 mM 0.1514 mL 0.7568 mL 1.5135 mL 3.027 mL 3.7838 mL
    50 mM 0.0303 mL 0.1514 mL 0.3027 mL 0.6054 mL 0.7568 mL
    100 mM 0.0151 mL 0.0757 mL 0.1514 mL 0.3027 mL 0.3784 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    根薯酮内酯A; Taccalonolide A CFN90596 108885-68-3 C36H46O14 = 702.74 10mg QQ客服:1413575084
    根薯酮内酯AJ; Taccalonolide AJ CFN90935 1349904-82-0 C34H44O14 = 676.7 5mg QQ客服:3257982914
    酸浆苦素L; Physalin L CFN90166 113146-74-0 C28H32O10 = 528.55 5mg QQ客服:3257982914
    酸浆苦味A; Physalin A CFN92940 23027-91-0 C28H30O10 = 526.5 5 mg QQ客服:1413575084
    酸浆苦素O; Physalin O CFN95097 120849-18-5 C28H32O10 = 528.55 5mg QQ客服:2159513211
    异酸浆苦味A; Isophysalin A CFN92936 1363398-67-7 C28H30O10 = 526.5 5mg QQ客服:2159513211
    酸浆苦味C; Physalin C CFN92938 27503-33-9 C28H30O9 = 510.53 5mg QQ客服:1413575084
    酸浆苦味B; Physalin B CFN92941 23133-56-4 C28H30O9 = 510.53 5mg QQ客服:2056216494
    酸浆苦味D; Physalin D CFN92939 54980-22-2 C28H32O11 = 544.55 5mg QQ客服:1413575084
    酸浆苦味素F; Physalin F CFN91811 57423-71-9 C28H30O10 = 526.5 10mg QQ客服:2056216494

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