根薯酮内酯AJ

Taccalonolide AJ

	产品编号	CFN90935
	CAS编号	1349904-82-0
	分子式 = 分子量	C₃₄H₄₄O₁₄ = 676.7
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Steroids
	植物来源	The rhizomes of Schizocapsa plantaginea Hance
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
根薯酮内酯AJ	CFN90935	1349904-82-0	1mg	QQ客服：1457312923
根薯酮内酯AJ	CFN90935	1349904-82-0	5mg	QQ客服：1457312923
根薯酮内酯AJ	CFN90935	1349904-82-0	10mg	QQ客服：1457312923
根薯酮内酯AJ	CFN90935	1349904-82-0	20mg	QQ客服：1457312923

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Julius Kühn-Institut (Germany)

Anna University (India)

Chinese University of Hong Kong (China)

Wageningen University (Netherlands)

University of Oslo (Norway)

Complutense University of Madrid (Spain)

University of Medicine and Pharmacy (Romania)

University of Parma (Italy)

University of Melbourne (Australia)

Srinakharinwirot University (Thailand)

Calcutta University (India)

Universite Libre de Bruxelles (Belgium)

Kyoto University (Japan)

University of Wollongong (Australia)

More...

Description:

Taccalonolide AJ is a microtubule stabilizer; it has excellent and highly persistent antitumor efficacy when administered directly to the tumor, suggesting that the lack of antitumor efficacy seen with systemic administration of AJ is likely due to its short half-life in vivo.

In vivo:

J Nat Prod. 2017 Feb 24;80(2):409-414.

Pharmacokinetic Analysis and in Vivo Antitumor Efficacy of Taccalonolides AF and AJ.[Pubmed: 28112516 ]

The taccalonolides are microtubule stabilizers that covalently bind tubulin and circumvent clinically relevant forms of resistance to other drugs of this class. Efforts are under way to identify a taccalonolide with optimal properties for clinical development. The structurally similar taccalonolides AF and AJ have comparable microtubule-stabilizing activities in vitro, but taccalonolide AF has excellent in vivo antitumor efficacy when administered systemically, while taccalonolide AJ does not elicit this activity even at maximum tolerated dose.
METHODS AND RESULTS:
The hypothesis that pharmacokinetic differences underlie the differential efficacies of taccalonolides AF and AJ was tested. The effects of serum on their in vivo potency, metabolism by human liver microsomes and in vivo pharmacokinetic properties were evaluated. Taccalonolides AF and AJ were found to have elimination half-lives of 44 and 8.1 min, respectively. Furthermore, taccalonolide AJ was found to have excellent and highly persistent antitumor efficacy when administered directly to the tumor, suggesting that the lack of antitumor efficacy seen with systemic administration of AJ is likely due to its short half-life in vivo.
CONCLUSIONS:
These results help define why some, but not all, taccalonolides inhibit the growth of tumors at systemically tolerable doses and prompt studies to further improve their pharmacokinetic profile and antitumor efficacy.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
异酸浆苦味素G; Isophysalin G	CFN95328	152221-21-1	C₂₈H₃₀O₁₀ = 526.5	5mg	QQ客服：2056216494
酸浆苦味H; Physalin H	CFN92937	70241-09-7	C₂₈H₃₁ClO₁₀ = 562.99	5mg	QQ客服：3257982914
4,7-二脱氢新酸浆苦素B; 4,7-Didehydroneophysalin B	CFN95317	134461-76-0	C₂₈H₂₈O₉ = 508.5	5mg	QQ客服：2159513211
酸浆苦味素X; Physalin X	CFN95329	72497-31-5	C₂₈H₃₀O₁₀ = 526.5	5mg	QQ客服：215959384
根薯酮内酯A; Taccalonolide A	CFN90596	108885-68-3	C₃₆H₄₆O₁₄ = 702.74	10mg	QQ客服：2159513211
根薯酮内酯AJ; Taccalonolide AJ	CFN90935	1349904-82-0	C₃₄H₄₄O₁₄ = 676.7	5mg	QQ客服：2056216494
酸浆苦素L; Physalin L	CFN90166	113146-74-0	C₂₈H₃₂O₁₀ = 528.55	5mg	QQ客服：2159513211
酸浆苦味A; Physalin A	CFN92940	23027-91-0	C₂₈H₃₀O₁₀ = 526.5	5 mg	QQ客服：1413575084
酸浆苦素O; Physalin O	CFN95097	120849-18-5	C₂₈H₃₂O₁₀ = 528.55	5mg	QQ客服：2056216494
异酸浆苦味A; Isophysalin A	CFN92936	1363398-67-7	C₂₈H₃₀O₁₀ = 526.5	5mg	QQ客服：2159513211

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	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.4778 mL	7.3888 mL	14.7776 mL	29.5552 mL	36.944 mL
5 mM	0.2956 mL	1.4778 mL	2.9555 mL	5.911 mL	7.3888 mL
10 mM	0.1478 mL	0.7389 mL	1.4778 mL	2.9555 mL	3.6944 mL
50 mM	0.0296 mL	0.1478 mL	0.2956 mL	0.5911 mL	0.7389 mL
100 mM	0.0148 mL	0.0739 mL	0.1478 mL	0.2956 mL	0.3694 mL