根薯酮内酯AJ
Taccalonolide AJ
|
|
产品编号 |
CFN90935 |
| CAS编号 |
1349904-82-0 |
| 分子式 = 分子量 |
C34H44O14 = 676.7 |
| 产品纯度 |
>=98% |
| 物理属性 |
Powder |
| 化合物类型 |
Steroids |
| 植物来源 |
The rhizomes of Schizocapsa plantaginea Hance |
| ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用 |
|
| 产品名称 |
产品编号 |
CAS编号 |
包装 |
QQ客服 |
| 根薯酮内酯AJ |
CFN90935 |
1349904-82-0 |
1mg |
QQ客服：2159513211 |
| 根薯酮内酯AJ |
CFN90935 |
1349904-82-0 |
5mg |
QQ客服：2159513211 |
| 根薯酮内酯AJ |
CFN90935 |
1349904-82-0 |
10mg |
QQ客服：2159513211 |
| 根薯酮内酯AJ |
CFN90935 |
1349904-82-0 |
20mg |
QQ客服：2159513211 |
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ChemFaces的产品在许多优秀和顶级科学期刊中被引用
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.
IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)PMID: 30417089
我们的产品现已经出口到下面的研究机构与大学，并且还在增涨
Shanghai University of TCM (China)
Technical University of Denmark (Denmark)
Univerzita Karlova v Praze (Czech Republic)
Worcester Polytechnic Institute (USA)
VIB Department of Plant Systems Biology, UGent (PSB) (Belgium)
University of Wuerzburg (Germany)
University of Vigo (Spain)
Celltrion Chemical Research Institute (Korea)
Institute of Tropical Disease Universitas Airlangga (Indonesia)
University of Maryland (USA)
Korea Intitute of Science and Technology (KIST) (Korea)
Tohoku University (Japan)
Kamphaengphet Rajabhat University (Thailand)
University of Perugia (Italy)
More...
国外学术期刊发表的引用ChemFaces产品的部分文献
| Description: |
Taccalonolide AJ is a microtubule stabilizer; it has excellent and highly persistent antitumor efficacy when administered directly to the tumor, suggesting that the lack of antitumor efficacy seen with systemic administration of AJ is likely due to its short half-life in vivo. |
| In vivo: |
| J Nat Prod. 2017 Feb 24;80(2):409-414. | | Pharmacokinetic Analysis and in Vivo Antitumor Efficacy of Taccalonolides AF and AJ.[Pubmed: 28112516 ] | The taccalonolides are microtubule stabilizers that covalently bind tubulin and circumvent clinically relevant forms of resistance to other drugs of this class. Efforts are under way to identify a taccalonolide with optimal properties for clinical development. The structurally similar taccalonolides AF and AJ have comparable microtubule-stabilizing activities in vitro, but taccalonolide AF has excellent in vivo antitumor efficacy when administered systemically, while taccalonolide AJ does not elicit this activity even at maximum tolerated dose.
METHODS AND RESULTS:
The hypothesis that pharmacokinetic differences underlie the differential efficacies of taccalonolides AF and AJ was tested. The effects of serum on their in vivo potency, metabolism by human liver microsomes and in vivo pharmacokinetic properties were evaluated. Taccalonolides AF and AJ were found to have elimination half-lives of 44 and 8.1 min, respectively. Furthermore, taccalonolide AJ was found to have excellent and highly persistent antitumor efficacy when administered directly to the tumor, suggesting that the lack of antitumor efficacy seen with systemic administration of AJ is likely due to its short half-life in vivo.
CONCLUSIONS:
These results help define why some, but not all, taccalonolides inhibit the growth of tumors at systemically tolerable doses and prompt studies to further improve their pharmacokinetic profile and antitumor efficacy. |
|
|
1 mg |
5 mg |
10 mg |
20 mg |
25 mg |
| 1 mM |
1.4778 mL |
7.3888 mL |
14.7776 mL |
29.5552 mL |
36.944 mL |
| 5 mM |
0.2956 mL |
1.4778 mL |
2.9555 mL |
5.911 mL |
7.3888 mL |
| 10 mM |
0.1478 mL |
0.7389 mL |
1.4778 mL |
2.9555 mL |
3.6944 mL |
| 50 mM |
0.0296 mL |
0.1478 mL |
0.2956 mL |
0.5911 mL |
0.7389 mL |
| 100 mM |
0.0148 mL |
0.0739 mL |
0.1478 mL |
0.2956 mL |
0.3694 mL |
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
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