根薯酮内酯AJ

Taccalonolide AJ

	产品编号	CFN90935
	CAS编号	1349904-82-0
	分子式 = 分子量	C₃₄H₄₄O₁₄ = 676.7
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Steroids
	植物来源	The rhizomes of Schizocapsa plantaginea Hance
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

提供自定义包装

产品名称	产品编号	CAS编号	包装	QQ客服
根薯酮内酯AJ	CFN90935	1349904-82-0	1mg	QQ客服：1413575084
根薯酮内酯AJ	CFN90935	1349904-82-0	5mg	QQ客服：1413575084
根薯酮内酯AJ	CFN90935	1349904-82-0	10mg	QQ客服：1413575084
根薯酮内酯AJ	CFN90935	1349904-82-0	20mg	QQ客服：1413575084

存储与注意事项

1. 在您收到产品后请检查产品。如无问题，请将产品存入冰霜并且样品瓶保持密封，产品可以存放长达24个月（2-8摄氏度）。

2. 只要有可能，产品溶解后，您应该在同一天应用于您的实验。但是，如果您需要提前做预实验，或者需要全部溶解，我们建议您将溶液以等分试样的形式存放在-20℃的密封小瓶中。通常，这些可用于长达两周。使用前，打开样品瓶前，我们建议您将产品平衡至室温至少1小时。

3. 需要更多关于溶解度，使用和处理的建议？请发送电子邮件至：service@chemfaces.com

订购流程

1. 在线订购

请联系我们QQ客服

2. 电话订购

请拨打电话：
027-84237683 或 027-84237783

3. 邮件或传真订购

发送电子邮件到: manager@chemfaces.com 或
发送传真到：027-84254680

提供订购信息

为了方便客户的订购，请需要订购ChemFaces产品的客户，在下单的时候请提供下列信息，以供我们快速为您建立发货信息。

1. 产品编号（CAS No.或产品名称）

2. 发货地址

3. 联系方法 (联系人，电话）

4. 开票抬头 (如果需要发票的客户）

5. 发票地址（发货地址与发票地址不同）

发货时间

1. 付款方式为100%预付款客户，我们将在确认收到货款后当天或1-3个工作日发货。

2. 付款方式为月结的客户，我们承诺在收到订单后当天或1-3个工作日内发货。

3. 如果客户所需要的产品，需要重新生产，我们有权告知客户，交货时间需要延期。

ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

CSIRO - Agriculture Flagship (Australia)

Worcester Polytechnic Institute (USA)

National Research Council of Canada (Canada)

Chinese University of Hong Kong (China)

University of Hertfordshire (United Kingdom)

University of Liège (Belgium)

Universidade da Beira Interior (Germany)

University of Wisconsin-Madison (USA)

Seoul National University (Korea)

VIT University (India)

Instituto Politécnico de Bragan?a (Portugal)

Mahidol University (Thailand)

Mahatma Gandhi University (India)

Shanghai University of TCM (China)

More...

Description:

Taccalonolide AJ is a microtubule stabilizer; it has excellent and highly persistent antitumor efficacy when administered directly to the tumor, suggesting that the lack of antitumor efficacy seen with systemic administration of AJ is likely due to its short half-life in vivo.

In vivo:

J Nat Prod. 2017 Feb 24;80(2):409-414.

Pharmacokinetic Analysis and in Vivo Antitumor Efficacy of Taccalonolides AF and AJ.[Pubmed: 28112516 ]

The taccalonolides are microtubule stabilizers that covalently bind tubulin and circumvent clinically relevant forms of resistance to other drugs of this class. Efforts are under way to identify a taccalonolide with optimal properties for clinical development. The structurally similar taccalonolides AF and AJ have comparable microtubule-stabilizing activities in vitro, but taccalonolide AF has excellent in vivo antitumor efficacy when administered systemically, while taccalonolide AJ does not elicit this activity even at maximum tolerated dose.
METHODS AND RESULTS:
The hypothesis that pharmacokinetic differences underlie the differential efficacies of taccalonolides AF and AJ was tested. The effects of serum on their in vivo potency, metabolism by human liver microsomes and in vivo pharmacokinetic properties were evaluated. Taccalonolides AF and AJ were found to have elimination half-lives of 44 and 8.1 min, respectively. Furthermore, taccalonolide AJ was found to have excellent and highly persistent antitumor efficacy when administered directly to the tumor, suggesting that the lack of antitumor efficacy seen with systemic administration of AJ is likely due to its short half-life in vivo.
CONCLUSIONS:
These results help define why some, but not all, taccalonolides inhibit the growth of tumors at systemically tolerable doses and prompt studies to further improve their pharmacokinetic profile and antitumor efficacy.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
酸浆苦味素G; Physalin G	CFN95104	76045-38-0	C₂₈H₃₀O₁₀ = 526.5	5mg	QQ客服：1457312923
异酸浆苦味素G; Isophysalin G	CFN95328	152221-21-1	C₂₈H₃₀O₁₀ = 526.5	5mg	QQ客服：215959384
酸浆苦味H; Physalin H	CFN92937	70241-09-7	C₂₈H₃₁ClO₁₀ = 562.99	5mg	QQ客服：215959384
4,7-二脱氢新酸浆苦素B; 4,7-Didehydroneophysalin B	CFN95317	134461-76-0	C₂₈H₂₈O₉ = 508.5	5mg	QQ客服：2056216494
酸浆苦味素X; Physalin X	CFN95329	72497-31-5	C₂₈H₃₀O₁₀ = 526.5	5mg	QQ客服：2056216494
根薯酮内酯A; Taccalonolide A	CFN90596	108885-68-3	C₃₆H₄₆O₁₄ = 702.74	10mg	QQ客服：3257982914
根薯酮内酯AJ; Taccalonolide AJ	CFN90935	1349904-82-0	C₃₄H₄₄O₁₄ = 676.7	5mg	QQ客服：1457312923
酸浆苦素L; Physalin L	CFN90166	113146-74-0	C₂₈H₃₂O₁₀ = 528.55	5mg	QQ客服：2056216494
酸浆苦味A; Physalin A	CFN92940	23027-91-0	C₂₈H₃₀O₁₀ = 526.5	5 mg	QQ客服：1413575084
酸浆苦素O; Physalin O	CFN95097	120849-18-5	C₂₈H₃₂O₁₀ = 528.55	5mg	QQ客服：2056216494

信息支持

公司简介
订购流程
付款方式
退换货政策

ChemFaces提供的产品仅用于科学研究使用，不用于诊断或治疗程序。

联系方式

电机：027-84237783
传真：027-84254680
在线QQ: 1413575084
E-Mail：manager@chemfaces.com

湖北省武汉沌口经济技术开区车城南路83号1号楼第三层厂房

ChemFaces为科学家，科研人员与企业提供快速的产品递送。我们通过瑞士SGS ISO 9001:2008质量体系认证天然化合物与对照品的研发和生产。

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.4778 mL	7.3888 mL	14.7776 mL	29.5552 mL	36.944 mL
5 mM	0.2956 mL	1.4778 mL	2.9555 mL	5.911 mL	7.3888 mL
10 mM	0.1478 mL	0.7389 mL	1.4778 mL	2.9555 mL	3.6944 mL
50 mM	0.0296 mL	0.1478 mL	0.2956 mL	0.5911 mL	0.7389 mL
100 mM	0.0148 mL	0.0739 mL	0.1478 mL	0.2956 mL	0.3694 mL